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    ACCESSION NUMBER:		0001193125-22-077740
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		52
    CONFORMED PERIOD OF REPORT:	20220427
    FILED AS OF DATE:		20220317
    DATE AS OF CHANGE:		20220317

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			CULLEN/FROST BANKERS, INC.
    		CENTRAL INDEX KEY:			0000039263
    		STANDARD INDUSTRIAL CLASSIFICATION:	NATIONAL COMMERCIAL BANKS [6021]
    		IRS NUMBER:				741751768
    		STATE OF INCORPORATION:			TX
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-13221
    		FILM NUMBER:		22746642

    	BUSINESS ADDRESS:
    		STREET 1:		111 W HOUSTON ST
    		CITY:			SAN ANTONIO
    		STATE:			TX
    		ZIP:			78205
    		BUSINESS PHONE:		210-220-4011

    	MAIL ADDRESS:
    		STREET 1:		POST OFFICE BOX 1600
    		CITY:			SAN ANTONIO
    		STATE:			TX
    		ZIP:			78296-1600

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	CULLEN FROST BANKERS INC
    		DATE OF NAME CHANGE:	19920703

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FROST BANK CORP
    		DATE OF NAME CHANGE:	19770823
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