<SEC-DOCUMENT>0001957799-23-000082.txt : 20230519
<SEC-HEADER>0001957799-23-000082.hdr.sgml : 20230519
<ACCEPTANCE-DATETIME>20230519141758
ACCESSION NUMBER:		0001957799-23-000082
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230519
DATE AS OF CHANGE:		20230519

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CULLEN/FROST BANKERS, INC.
		CENTRAL INDEX KEY:			0000039263
		STANDARD INDUSTRIAL CLASSIFICATION:	NATIONAL COMMERCIAL BANKS [6021]
		IRS NUMBER:				741751768
		STATE OF INCORPORATION:			TX
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-13221
		FILM NUMBER:		23939431

	BUSINESS ADDRESS:	
		STREET 1:		111 W HOUSTON ST
		CITY:			SAN ANTONIO
		STATE:			TX
		ZIP:			78205
		BUSINESS PHONE:		210-220-4011

	MAIL ADDRESS:	
		STREET 1:		POST OFFICE BOX 1600
		CITY:			SAN ANTONIO
		STATE:			TX
		ZIP:			78296-1600

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CULLEN FROST BANKERS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FROST BANK CORP
		DATE OF NAME CHANGE:	19770823

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FROST PATRICK B
		CENTRAL INDEX KEY:			0001128400

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		100 WEST HOUSTON ST
		CITY:			SAN ANTONIO
		STATE:			TX
		ZIP:			78205
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001128400</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000039263</issuerCik>
      <issuerName>CULLEN/FROST BANKERS, INC.</issuerName>
      <secFileNumber>001-13221</secFileNumber>
      <issuerAddress>
        <com:street1>111 W HOUSTON ST</com:street1>
        <com:city>SAN ANTONIO</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78205</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>210-220-4011</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>FROST PATRICK B</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Advisors</name>
        <address>
          <com:street1>One N Jefferson</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6617</noOfUnitsSold>
      <aggregateMarketValue>668006.07</aggregateMarketValue>
      <noOfUnitsOutstanding>64398599</noOfUnitsOutstanding>
      <approxSaleDate>05/19/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/19/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6617</amountOfSecuritiesAcquired>
      <paymentDate>05/19/2023</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/19/2023</noticeDate>
      <signature>Patrick B Frost</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
