EXHIBIT 24.1

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Phillip D. Green, Daniel J. Geddes and Matthew B. Henson, and each of them, his or her true and lawful attorneys-in-fact and agents, and with power of substitution and resubstitution, for him/her and in his/her name, place and stead, and in any and all capacities, to sign the Annual Report on Form 10-K of Cullen/Frost Bankers, Inc. for the fiscal year ended December 31, 2024, to sign any and all amendments thereto, and to file such Annual Report and amendments, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he/she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or either of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Signature			Title			Date
/s/ PHILLIP D. GREEN			Chairman of the Board, Director, and Chief Executive Officer (Principal Executive Officer)			January 29, 2025
Phillip D. Green
/s/ DANIEL J. GEDDES			Group Executive Vice President and Chief Financial Officer (Principal Financial Officer)			January 29, 2025
Daniel J. Geddes
/s/ MATTHEW B. HENSON			Executive Vice President and Chief Accounting Officer (Principal Accounting Officer)			January 29, 2025
Matthew B. Henson
/s/ HOPE ANDRADE			Director			January 29, 2025
Hope Andrade
/s/ CHRIS AVERY			Director			January 29, 2025
Chris Avery
/s/ ANTHONY R. CHASE			Director			January 29, 2025
Anthony R. Chase
/s/ CYNTHIA COMPARIN			Director			January 29, 2025
Cynthia Comparin
/s/ SAM DAWSON			Director			January 29, 2025
Sam Dawson
/s/ CRAWFORD H. EDWARDS			Director			January 29, 2025
Crawford H. Edwards
/s/ DAVID J. HAEMISEGGER			Director			January 29, 2025
David J. Haemisegger
/s/ CHARLES W. MATTHEWS			Director			January 29, 2025
Charles W. Matthews
/s/ JOSEPH A. PIERCE			Director			January 29, 2025
Joseph A. Pierce
/s/ LINDA B. RUTHERFORD			Director			January 29, 2025
Linda B. Rutherford
/s/ JOHN H. WILLOME			Director			January 29, 2025
John H. Willome