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Share-Based Compensation (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2025 | Mar. 31, 2024
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total share-based compensation expense, pre-tax | $ 67,653 | $ 61,441
Income tax benefit from share-based compensation expense | (9,534) | (3,399)
Total share-based compensation expense, net of tax | 58,119 | 58,042
Selling, general and administrative |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total share-based compensation expense, pre-tax | 41,674 | 40,213
Research and development |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total share-based compensation expense, pre-tax | 20,930 | 18,831
Cost of product sales |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total share-based compensation expense, pre-tax | $ 5,049 | $ 2,397

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Amount of tax benefit for recognition of expense of award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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