<SEC-DOCUMENT>0001989533-25-000003.txt : 20251119
<SEC-HEADER>0001989533-25-000003.hdr.sgml : 20251119
<ACCEPTANCE-DATETIME>20251119205907
ACCESSION NUMBER:		0001989533-25-000003
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251119
DATE AS OF CHANGE:		20251119

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Jazz Pharmaceuticals plc
		CENTRAL INDEX KEY:			0001232524
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				981032470
		STATE OF INCORPORATION:			L2
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-33500
		FILM NUMBER:		251500811

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		FIFTH FLOOR, WATERLOO EXCHANGE
		STREET 2:		WATERLOO ROAD
		CITY:			DUBLIN
		PROVINCE COUNTRY:   	L2
		ZIP:			D04 E5W7
		BUSINESS PHONE:		353-1-634-7800

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		FIFTH FLOOR, WATERLOO EXCHANGE
		STREET 2:		WATERLOO ROAD
		CITY:			DUBLIN
		PROVINCE COUNTRY:   	L2
		ZIP:			D04 E5W7

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	JAZZ PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20030513

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Henderson Mary Elizabeth
		CENTRAL INDEX KEY:			0001989533
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		3170 PORTER DRIVE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001989533</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001232524</issuerCik>
      <issuerName>Jazz Pharmaceuticals plc</issuerName>
      <secFileNumber>001-33500</secFileNumber>
      <issuerAddress>
        <com:street1>FIFTH FLOOR, WATERLOO EXCHANGE</com:street1>
        <com:street2>WATERLOO ROAD</com:street2>
        <com:city>DUBLIN</com:city>
        <com:stateOrCountry>L2</com:stateOrCountry>
        <com:zipCode>D04 E5W7</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>353-1-634-7800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Henderson Mary Elizabeth</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>ETRADE FINANCIAL CORPORATION</name>
        <address>
          <com:street1>ETRADE FINANCIAL CORPORATION</com:street1>
          <com:street2>3 EDISON DRIVE</com:street2>
          <com:city>ALPHARETTA</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30005</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2961</noOfUnitsSold>
      <aggregateMarketValue>376740.00</aggregateMarketValue>
      <noOfUnitsOutstanding>60765116</noOfUnitsOutstanding>
      <approxSaleDate>11/19/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/18/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK VESTING</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2961</amountOfSecuritiesAcquired>
      <paymentDate>11/18/2025</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/19/2025</noticeDate>
      <signature>/s/Paz Dizon by power of attorney for Mary Elizabeth Henderson</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
