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Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
OPERATING ACTIVITIES: |  |
Net loss | $ (217,613) | $ (206,304)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 21,335 | 20,976
Operating lease costs | 15,226 | 14,708
Stock-based compensation | 54,276 | 44,620
Amortization of debt issuance costs | 1,290 | 1,287
Amortization of premium (discount) on marketable debt securities | 107 | (3,085)
Unrealized losses (gains) on marketable equity securities | 45,539 | (67,879)
Impairment of non-marketable equity securities and other related assets | 0 | 29,054
Other | 1,385 | 108
Cash effect of changes in operating assets and liabilities: |  |
Accounts receivable, net | (11,737) | 10,695
Inventory, net | (5,035) | (8,931)
Prepaid expenses and other current assets, net | (8,661) | (891)
Other assets, net | (130) | 1,700
Accounts payable and accrued liabilities | (15,025) | 16,512
Operating lease liabilities | (17,696) | (14,970)
Deferred revenue | 12,453 | (6,056)
Net cash used in operating activities | (124,286) | (168,456)
INVESTING ACTIVITIES: |  |
Purchase of marketable debt securities | 0 | (561,339)
Maturity of marketable debt securities | 35,000 | 492,700
Purchase of non-marketable equity securities and other related assets | 0 | (1,227)
Purchase of property and equipment | (12,011) | (14,037)
Net cash provided by (used in) investing activities | 22,989 | (83,903)
FINANCING ACTIVITIES: |  |
Proceeds from issuance of common stock upon exercise of stock options | 2,577 | 220
Proceeds from issuances of common stock under employee stock purchase plan | 7,212 | 6,697
Taxes paid related to net share settlement of restricted stock units | (4,784) | (5,109)
Proceeds from follow-on public offering | 0 | 402,500
Payment of offering costs related to follow-on public offering | 0 | (21,271)
Other | (181) | (37)
Net cash provided by financing activities | 4,824 | 383,000
Net effect of foreign exchange rate changes on cash, cash equivalents and restricted cash | (1,975) | (1,415)
Net (decrease) increase in cash, cash equivalents and restricted cash | (98,448) | 129,226
Cash, cash equivalents and restricted cash—Beginning of period | 1,133,687 | 141,948
Cash, cash equivalents and restricted cash—End of period | 1,035,239 | 271,174
Reconciliation of cash, cash equivalents and restricted cash: |  |
Cash and cash equivalents | 933,694 | 271,073
Restricted cash – included in cash, cash equivalents and restricted cash | 101,545 | 101
Total cash, cash equivalents and restricted cash | $ 1,035,239 | $ 271,174

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