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Stock-Based Compensation - Narrative (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended 38 Months Ended
Feb. 23, 2024
shares
Mar. 02, 2023
shares
Jan. 01, 2020
shares
Jul. 31, 2022
USD ($)
grantee
Jun. 30, 2022
$ / shares
May 31, 2021
$ / shares
Nov. 30, 2020
$ / shares
May 31, 2020
tranche
shares
Oct. 31, 2018
shares
Sep. 30, 2018
shares
Dec. 31, 2024
USD ($)
$ / shares
shares
Dec. 31, 2023
USD ($)
$ / shares
shares
Dec. 31, 2022
USD ($)
$ / shares
shares
Dec. 31, 2023
USD ($)
$ / shares
shares
Dec. 31, 2021
$ / shares
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Weighted average grant date fair value, grants in period (in usd per share) | $ / shares                     $ 17.20 $ 19.90 $ 28.61    
Stock based compensation not recognized | $                     $ 40,700        
Stock based compensation not recognized, period for recognition (in years)                     2 years 1 month 6 days        
Total stock-based compensation expense | $                     $ 140,411 $ 90,759 $ 94,685    
Granted (in shares)                     1,440,273 1,000,760 1,051,466    
Granted (in shares)                       0 0    
Granted (in usd per share) | $ / shares                     $ 27.07 $ 30.80 $ 44.86    
Shares underlying outstanding stock options                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Exercises in period, intrinsic value | $                     $ 9,400 $ 1,000 $ 12,200    
Expected dividend yield                     0.00% 0.00% 0.00%    
Restricted stock units                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Stock based compensation not recognized, period for recognition (in years)                     2 years 2 months 12 days        
Stock based compensation not recognized, restricted stock | $                     $ 181,500        
Weighted-average grant date fair value, granted (in usd per share) | $ / shares                     $ 25.94 $ 26.62 $ 45.04    
Granted (in shares)                     5,004,910 2,436,947 2,902,217    
Unvested balance (in shares)                     7,020,251 4,346,785 3,687,888 4,346,785 1,498,553
Weighted average grant date fair value (in usd per share) | $ / shares                     $ 30.11 $ 42.63 $ 60.70 $ 42.63 $ 109.72
PSUs                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Weighted average grant date fair value, grants in period (in usd per share) | $ / shares             $ 113.40                
Stock based compensation not recognized, period for recognition (in years)                     1 year 10 months 24 days        
Stock based compensation not recognized, restricted stock | $                     $ 16,100        
Additional service period (in months)             2 years                
Weighted average grant date fair value, Vested in period (in usd per share) | $ / shares           $ 148.19                  
Total stock-based compensation expense | $                     33,300 $ 2,600 $ 1,300 $ 0  
Cumulative charge | $                     $ 24,800        
Granted (in shares)                     219,161        
Total market-based restricted stock units approved and granted (in shares)                     913,829 126,041 26,935    
Weighted-average grant date fair value, granted (in usd per share) | $ / shares                     $ 18.73 $ 32.84 $ 37.50    
Granted (in shares)                     913,829 126,041 26,935    
Unvested balance (in shares)                     1,290,684 412,490 341,713 412,490 374,596
Weighted average grant date fair value (in usd per share) | $ / shares                     $ 37.07 $ 91.25 $ 110.64 $ 91.25 $ 116.58
PSUs | Minimum                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Service period (in years)             7 months 6 days                
Vesting period (in years)             7 months 6 days                
PSUs | Maximum                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Service period (in years)             4 years                
Vesting period (in years)             4 years 6 months                
Shares underlying unvested performance-based restricted stock units                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Service period (in years)             4 years                
Vesting period (in years)             6 months                
MSUs                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Total stock-based compensation expense | $                     $ 16,100        
Number of tranches | tranche               3              
Market-based restricted stock share price goal (in days)               30 days              
Weighted-average grant date fair value, granted (in usd per share) | $ / shares                     $ 67.00        
Unvested balance (in shares)                       2,260,764   2,260,764  
Weighted average grant date fair value (in usd per share) | $ / shares                       $ 65.20   $ 65.20  
MSUs | Chief Executive Officer                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Total market-based restricted stock units approved and granted (in shares)               1,695,574              
MSUs | Minimum                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Service period (in years)                     9 months 29 days        
MSUs | Maximum                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Service period (in years)                     2 years 25 days        
ESPP obligation                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Additional amount of shares available (in shares) 1,106,700 1,026,194 942,614                        
Stock based compensation not recognized, period for recognition (in years)                     4 months 24 days        
Stock based compensation not recognized, restricted stock | $                     $ 2,500        
Total stock-based compensation expense | $                     $ 4,700 $ 5,100 $ 4,600    
Expected dividend yield                     0.00% 0.00% 0.00%    
Employee stock purchase plan, maximum employee subscription rate (as a percent)                     10.00%        
Shares authorized (in shares) 1,106,700 1,026,194 942,614                        
Employee stock purchase plan, purchase price of common stock (as a percent)                     85.00%        
Purchase period (in months)                     6 months        
Common stock issued under employee stock purchase plan (in shares)                     577,758 464,870 307,953    
2012 Stock Plan                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Shares canceled (in shares)                 508,847            
2018 Incentive Award Plan                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Additional amount of shares available (in shares)                 3,689,000            
Additional amount of shares available (percent)                 400.00%            
Percentage of common stock outstanding                   4.00%          
Shares authorized (in shares)                 3,689,000            
AMEA 2020 Plan | Guardant Health AMEA, Inc | Common Class B                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Stock based compensation not recognized | $       $ 4,100                      
Stock based compensation not recognized, period for recognition (in years)       2 years 2 months 12 days                      
Granted (in usd per share) | $ / shares         $ 4.44                    
Issuance of exercise of vested stock option granted | grantee       39                      
Settled of tender, amount | $       $ 13,700                      
2018 Employee Stock Purchase Plan | ESPP obligation                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Additional amount of shares available (in shares)                   1,106,700          
Common stock, shares reserved for future issuance (in shares)                   922,250          
Percentage of common stock outstanding                   1.00%          
Shares authorized (in shares)                   1,106,700