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Summary of Significant Accounting Policies - Narrative (Details)
3 Months Ended 12 Months Ended
Mar. 31, 2025
USD ($)
revenue_source
segment
Mar. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2024
USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Restricted cash $ 105,281,000 $ 100,230,000   $ 104,215,000
Non-marketable equity and other investments 11,100,000     16,100,000
Impairment of non-marketable equity securities 5,000,000   $ 22,100,000  
Impairment or adjustments of non-marketable securities 0 0    
Contract asset $ 4,200,000     3,400,000
Number of operating segments | segment 1      
Impairment of goodwill $ 0      
Number of revenue sources | revenue_source 4      
Revenue recognized in current period, delivered in prior periods $ 12,200,000 15,800,000    
Deferred revenue 44,000,000.0     41,600,000
Deferred revenue long term 7,700,000     6,100,000
Deferred revenue recognized 10,100,000 $ 7,100,000    
TwinStrand Biosciences And University Of Washington vs. Guardant Health, Inc.        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Restricted cash $ 104,600,000     $ 103,600,000
Minimum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Useful life (years) 6 years      
Minimum | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-04-01        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Remaining performance obligation, expected recognition period 1 year      
Maximum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Useful life (years) 12 years      
Maximum | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-04-01        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Remaining performance obligation, expected recognition period 2 years