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Summary of Significant Accounting Policies - Narrative (Details)
 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2025
USD ($)
revenue_source
segment
Sep. 30, 2024
USD ($)
Sep. 30, 2025
USD ($)
segment
revenue_source
Sep. 30, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2024
USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Restricted cash $ 109,502,000 $ 103,346,000 $ 109,502,000 $ 103,346,000   $ 104,215,000
Number of investees deemed variable interest entity, not primary beneficiary | segment 1   1      
Non-marketable equity and other investments $ 20,100,000   $ 20,100,000     16,100,000
Impairment of non-marketable equity securities     5,000,000   $ 22,100,000  
Impairment or adjustments of non-marketable securities     0 0    
Contract asset 5,100,000   $ 5,100,000     3,400,000
Number of operating segments | segment     1      
Impairment of goodwill $ 0   $ 0      
Number of revenue sources | revenue_source 4   4      
Revenue recognized in current period, delivered in prior periods $ 16,800,000 $ 18,200,000 $ 25,900,000 31,900,000    
Deferred revenue 56,400,000   56,400,000     41,600,000
Deferred revenue long term $ 9,500,000   9,500,000     6,100,000
Deferred revenue recognized     $ 29,100,000 $ 12,600,000    
Minimum            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Useful life (years) 6 years   6 years      
Minimum | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-10-01            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Remaining performance obligation, expected recognition period 1 year   1 year      
Maximum            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Useful life (years) 12 years   12 years      
Maximum | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-10-01            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Remaining performance obligation, expected recognition period 2 years   2 years      
TwinStrand Biosciences And University Of Washington vs. Guardant Health, Inc.            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Restricted cash $ 106,700,000   $ 106,700,000     $ 103,600,000