<SEC-DOCUMENT>0001336504-25-000007.txt : 20251208
<SEC-HEADER>0001336504-25-000007.hdr.sgml : 20251208
<ACCEPTANCE-DATETIME>20251208213619
ACCESSION NUMBER:		0001336504-25-000007
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251205
FILED AS OF DATE:		20251208
DATE AS OF CHANGE:		20251208

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CLARK IAN T
		CENTRAL INDEX KEY:			0001336504
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38683
		FILM NUMBER:		251557448

	MAIL ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Guardant Health, Inc.
		CENTRAL INDEX KEY:			0001576280
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				454139254
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
		BUSINESS PHONE:		855-698-8887

	MAIL ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1765247776.xml
<DESCRIPTION>FORM 4
<TEXT>
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    <periodOfReport>2025-12-05</periodOfReport>

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        <issuerName>Guardant Health, Inc.</issuerName>
        <issuerTradingSymbol>GH</issuerTradingSymbol>
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            <rptOwnerStreet2></rptOwnerStreet2>
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            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94304</rptOwnerZipCode>
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        <nonDerivativeTransaction>
            <securityTitle>
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                    <value>107.2703</value>
                    <footnoteId id="F2"/>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
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                    <value>13251</value>
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                    <value>I</value>
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                    <value>By The Thornton-Clark Family Trust, J Thornton-Clark &amp; I Clark TTE Account</value>
                </natureOfOwnership>
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        <nonDerivativeTransaction>
            <securityTitle>
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                <transactionCode>S</transactionCode>
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                <transactionShares>
                    <value>3400</value>
                </transactionShares>
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                    <value>108.0454</value>
                    <footnoteId id="F3"/>
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                    <value>D</value>
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            </ownershipNature>
        </nonDerivativeTransaction>
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    <derivativeTable>
        <derivativeTransaction>
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            </conversionOrExercisePrice>
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                <value>2025-12-05</value>
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            <transactionAmounts>
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                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
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            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F4"/>
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            <expirationDate>
                <value>2032-06-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
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            </transactionDate>
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                <transactionCode>M</transactionCode>
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                <value>2033-06-14</value>
            </expirationDate>
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                    <value>D</value>
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            <exerciseDate>
                <footnoteId id="F6"/>
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                <value>2034-06-12</value>
            </expirationDate>
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    <footnotes>
        <footnote id="F1">Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging  from $105.88 to $106.87. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.</footnote>
        <footnote id="F2">Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging  from $106.88 to $107.87. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.</footnote>
        <footnote id="F3">Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging  from $107.885 to $108.480. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.</footnote>
        <footnote id="F4">The Stock Options vest in full on the one-year anniversary of the grant date, June 15, 2022 or the date of the next year annual stockholders meeting, whichever is earlier.</footnote>
        <footnote id="F5">The stock option vests in full on the one-year anniversary of the grant date, June 14, 2023 or the date of the next year annual stockholders meeting, whichever is earlier.</footnote>
        <footnote id="F6">The stock option vests in full on the one-year anniversary of the grant date, June 12, 2024 or the date of the next year annual stockholders meeting, whichever is earlier.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ John G. Saia, as attorney-in-fact for Ian T. Clark</signatureName>
        <signatureDate>2025-12-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
