<SEC-DOCUMENT>0001011438-25-000123.txt : 20250213
<SEC-HEADER>0001011438-25-000123.hdr.sgml : 20250213
<ACCEPTANCE-DATETIME>20250213182045
ACCESSION NUMBER:		0001011438-25-000123
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250213
DATE AS OF CHANGE:		20250213

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Guardant Health, Inc.
		CENTRAL INDEX KEY:			0001576280
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				454139254
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90826
		FILM NUMBER:		25622179

	BUSINESS ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
		BUSINESS PHONE:		855-698-8887

	MAIL ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CADIAN CAPITAL MANAGEMENT, LP
		CENTRAL INDEX KEY:			0001423686
		ORGANIZATION NAME:           	
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		535 MADISON AVENUE, 36TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-792-8800

	MAIL ADDRESS:	
		STREET 1:		535 MADISON AVENUE, 36TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CADIAN CAPITAL MANAGEMENT, LLC
		DATE OF NAME CHANGE:	20080111
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>SCHEDULE 13G/A</submissionType>
<previousAccessionNumber>0001011438-24-000644</previousAccessionNumber>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001423686</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<amendmentNo>1</amendmentNo>
<securitiesClassTitle>Common Stock, par value $0.00001 per share</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0001576280</issuerCik>
<issuerName>Guardant Health, Inc.</issuerName>
<issuerCusip>40131M109</issuerCusip>
<issuerPrincipalExecutiveOfficeAddress>
<com:street1>3100 Hanover Street</com:street1>
<com:city>Palo Alto</com:city>
<com:stateOrCountry>CA</com:stateOrCountry>
<com:zipCode>94304</com:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
</coverPageHeader>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Cadian Capital Management, LP</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>5221565</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>5221565</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5221565</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>4.2</classPercent>
<typeOfReportingPerson>IA</typeOfReportingPerson>
<typeOfReportingPerson>PN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Cadian Capital Management GP, LLC</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>5221565</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>5221565</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5221565</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>4.2</classPercent>
<typeOfReportingPerson>OO</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>ERIC BANNASCH</reportingPersonName>
<citizenshipOrOrganization>X1</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>5221565</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>5221565</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5221565</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>4.2</classPercent>
<typeOfReportingPerson>IN</typeOfReportingPerson>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<items>
<item1>
<issuerName>Guardant Health, Inc.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>3100 Hanover Street, Palo Alto, California, 94304</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>(i) Cadian Capital Management, LP, (ii) Cadian Capital Management GP, LLC, and (iii) Eric Bannasch (collectively, the "Reporting Persons")</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>For each of the Reporting Persons:  535 Madison Avenue, 36th Floor, New York, New York 10022</principalBusinessOfficeOrResidenceAddress>
<citizenship>(i) Cadian Capital Management, LP is a Delaware limited partnership, (ii) Cadian Capital Management GP, LLC is a Delaware limited liability company, and (iii) Eric Bannasch is a United States citizen.</citizenship>
</item2>
<item3>
<notApplicableFlag>N</notApplicableFlag>
<typeOfPersonFiling>IA</typeOfPersonFiling>
<typeOfPersonFiling>HC</typeOfPersonFiling>
</item3>
<item4>
<amountBeneficiallyOwned>As of December 31, 2024, each of the Reporting Persons may have been deemed to have beneficially owned 5,221,565 shares of Common Stock, par value $0.00001 per share ("Common Stock"), of Guardant Health, Inc. (the "Issuer").  All securities reported in this Schedule 13G were directly held by Cadian Master Fund L.P. and Cadian Opportunities Master Fund LP (collectively, the "Advisory Clients"), advisory clients of Cadian Capital Management, LP (the "Adviser").  Pursuant to Investment Management Agreements between the Advisory Clients and the Adviser, the Adviser exercises exclusive voting and investment power over securities directly held by the Advisory Clients.  Cadian Capital Management GP, LLC is the general partner of the Adviser.  Eric Bannasch is the sole managing member of Cadian Capital Management GP, LLC.</amountBeneficiallyOwned>
<classPercent>As of December 31, 2024, each of the Reporting Persons may have been deemed to have beneficially owned approximately 4.2% of the shares of Common Stock of the Issuer outstanding, based on 123,554,612 shares of Common Stock outstanding as of November 1, 2024, as disclosed in the Issuer's Form 10-Q filed with the Securities and Exchange Commission on November 6, 2024.</classPercent>
<numberOfSharesPersonHas>
<solePowerOrDirectToVote>As of December 31, 2024, each of the Reporting Persons may have been deemed to have had sole power to vote or to direct the vote of 0 shares of Common Stock.</solePowerOrDirectToVote>
<sharedPowerOrDirectToVote>As of December 31, 2024, each of the Reporting Persons may have been deemed to have had shared power to vote or to direct the vote of 5,221,565 shares of Common Stock.</sharedPowerOrDirectToVote>
<solePowerOrDirectToDispose>As of December 31, 2024, each of the Reporting Persons may have been deemed to have had sole power to dispose or to direct the disposition of 0 shares of Common Stock.</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>As of December 31, 2024, each of the Reporting Persons may have been deemed to have had shared power to dispose or to direct the disposition of 5,221,565 shares of Common Stock.</sharedPowerOrDirectToDispose>
</numberOfSharesPersonHas>
</item4>
<item5>
<notApplicableFlag>N</notApplicableFlag>
<classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
</item5>
<item6>
<notApplicableFlag>N</notApplicableFlag>
<ownershipMoreThan5PercentOnBehalfOfAnotherPerson>All securities reported in this Schedule 13G were directly held by the Advisory Clients.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
</item6>
<item7>
<notApplicableFlag>N</notApplicableFlag>
<subsidiaryIdentificationAndClassification>The disclosure regarding the relationships among the Reporting Persons in Item 4 is incorporated by reference herein.</subsidiaryIdentificationAndClassification>
</item7>
<item8>
<notApplicableFlag>Y</notApplicableFlag>
</item8>
<item9>
<notApplicableFlag>Y</notApplicableFlag>
</item9>
<item10>
<notApplicableFlag>N</notApplicableFlag>
<certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
</item10>
</items>
<signatureInformation>
<reportingPersonName>Cadian Capital Management, LP</reportingPersonName>
<signatureDetails>
<signature>/s/ Eric Bannasch</signature>
<title>Eric Bannasch/Managing Member, Cadian Capital Management GP, LLC, its General Partner</title>
<date>02/13/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Cadian Capital Management GP, LLC</reportingPersonName>
<signatureDetails>
<signature>/s/ Eric Bannasch</signature>
<title>Eric Bannasch/Managing Member</title>
<date>02/13/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>ERIC BANNASCH</reportingPersonName>
<signatureDetails>
<signature>/s/ Eric Bannasch</signature>
<title>Eric Bannasch/Self</title>
<date>02/13/2025</date>
</signatureDetails>
</signatureInformation>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
