<SEC-DOCUMENT>0001972481-25-000313.txt : 20251215
<SEC-HEADER>0001972481-25-000313.hdr.sgml : 20251215
<ACCEPTANCE-DATETIME>20251215170807
ACCESSION NUMBER:		0001972481-25-000313
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251215
DATE AS OF CHANGE:		20251215

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Guardant Health, Inc.
		CENTRAL INDEX KEY:			0001576280
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				454139254
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38683
		FILM NUMBER:		251572432

	BUSINESS ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
		BUSINESS PHONE:		855-698-8887

	MAIL ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Eltoukhy Helmy
		CENTRAL INDEX KEY:			0001752968
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		3100 HANOVER STREET
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001752968</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001576280</issuerCik>
      <issuerName>Guardant Health, Inc.</issuerName>
      <secFileNumber>001-38683</secFileNumber>
      <issuerAddress>
        <com:street1>3100 HANOVER STREET</com:street1>
        <com:city>PALO ALTO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94304</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>855-698-8887</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Eltoukhy Helmy</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Stifel Nicolaus &amp; Company Inc</name>
        <address>
          <com:street1>501 N Broadway</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63102</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>90565</noOfUnitsSold>
      <aggregateMarketValue>9402223.00</aggregateMarketValue>
      <noOfUnitsOutstanding>126041089</noOfUnitsOutstanding>
      <approxSaleDate>12/15/2025</approxSaleDate>
      <securitiesExchangeName> Nasdaq </securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>11/19/2021</acquiredDate>
      <natureOfAcquisitionTransaction> Purchase </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired> Open Market </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>36065</amountOfSecuritiesAcquired>
      <paymentDate>11/19/2021</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>11/23/2021</acquiredDate>
      <natureOfAcquisitionTransaction> Purchase </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired> Open Market </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>54500</amountOfSecuritiesAcquired>
      <paymentDate>11/23/2021</paymentDate>
      <natureOfPayment> Cash </natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/15/2025</noticeDate>
      <signature>/s/ Brian Schneiweiss, as a duly authorized representative of STIFEL, as attorney-in-fact for Helmy Eltoukhy</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
