<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with WebFilings-->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.bio-rad.com/role/A10IncomeTaxes" xlink:href="bio-20120331.xsd#A10IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A10IncomeTaxesDetails" xlink:href="bio-20120331.xsd#A10IncomeTaxesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A11SegmentInformation" xlink:href="bio-20120331.xsd#A11SegmentInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A11SegmentInformationDetails" xlink:href="bio-20120331.xsd#A11SegmentInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A11SegmentInformationTables" xlink:href="bio-20120331.xsd#A11SegmentInformationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A11SegmentProfitReconciliationDetails" xlink:href="bio-20120331.xsd#A11SegmentProfitReconciliationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A12LegalProceedings" xlink:href="bio-20120331.xsd#A12LegalProceedings" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A12LegalProceedingsDetails" xlink:href="bio-20120331.xsd#A12LegalProceedingsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A1BasisOfPresentationAndUseOfEstimatesImmaterialErrorCorrectionsDetails" xlink:href="bio-20120331.xsd#A1BasisOfPresentationAndUseOfEstimatesImmaterialErrorCorrectionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A1OrganizationConsolidationAndPresentationOfFinancialStatements" xlink:href="bio-20120331.xsd#A1OrganizationConsolidationAndPresentationOfFinancialStatements" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A2Acquisitions" xlink:href="bio-20120331.xsd#A2Acquisitions" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A2AcquisitionsDetails" xlink:href="bio-20120331.xsd#A2AcquisitionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A2AcquisitionsTables" xlink:href="bio-20120331.xsd#A2AcquisitionsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3AmortizedCostAndFairValueOfDebtSecuritiesDetails" xlink:href="bio-20120331.xsd#A3AmortizedCostAndFairValueOfDebtSecuritiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3FairValueAndGrossUnrealizedLossesWithUnrealizedLossesDetails" xlink:href="bio-20120331.xsd#A3FairValueAndGrossUnrealizedLossesWithUnrealizedLossesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3FairValueInvestmentsDetails" xlink:href="bio-20120331.xsd#A3FairValueInvestmentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3FairValueMeasurements" xlink:href="bio-20120331.xsd#A3FairValueMeasurements" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3FairValueMeasurements3ContingentConsiderationDetails" xlink:href="bio-20120331.xsd#A3FairValueMeasurements3ContingentConsiderationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3FairValueMeasurementsFairValueLevelTableDetails" xlink:href="bio-20120331.xsd#A3FairValueMeasurementsFairValueLevelTableDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3FairValueMeasurementsTables" xlink:href="bio-20120331.xsd#A3FairValueMeasurementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3ForeignExchangeForwardContractsDetails" xlink:href="bio-20120331.xsd#A3ForeignExchangeForwardContractsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A3ShortTermInvestmentsDetails" xlink:href="bio-20120331.xsd#A3ShortTermInvestmentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOther" xlink:href="bio-20120331.xsd#A4IntangibleAssetsGoodwillAndOther" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOtherDetails" xlink:href="bio-20120331.xsd#A4IntangibleAssetsGoodwillAndOtherDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOtherIntangibleAssetsDetails" xlink:href="bio-20120331.xsd#A4IntangibleAssetsGoodwillAndOtherIntangibleAssetsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOtherTables" xlink:href="bio-20120331.xsd#A4IntangibleAssetsGoodwillAndOtherTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A5ProductWarrantyLiability" xlink:href="bio-20120331.xsd#A5ProductWarrantyLiability" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A5ProductWarrantyLiabilityDetails" xlink:href="bio-20120331.xsd#A5ProductWarrantyLiabilityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A5ProductWarrantyLiabilityTables" xlink:href="bio-20120331.xsd#A5ProductWarrantyLiabilityTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A6LongTermDebt" xlink:href="bio-20120331.xsd#A6LongTermDebt" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A6LongTermDebtDetails" xlink:href="bio-20120331.xsd#A6LongTermDebtDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A6LongTermDebtTables" xlink:href="bio-20120331.xsd#A6LongTermDebtTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A7NoncontrollingInterest" xlink:href="bio-20120331.xsd#A7NoncontrollingInterest" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A7NoncontrollingInterestDetails" xlink:href="bio-20120331.xsd#A7NoncontrollingInterestDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A7NoncontrollingInterestTables" xlink:href="bio-20120331.xsd#A7NoncontrollingInterestTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A7NoncontrollingInterestsDetails" xlink:href="bio-20120331.xsd#A7NoncontrollingInterestsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A8EarningsPerShare" xlink:href="bio-20120331.xsd#A8EarningsPerShare" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A8EarningsPerShareDetails" xlink:href="bio-20120331.xsd#A8EarningsPerShareDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A8EarningsPerShareTables" xlink:href="bio-20120331.xsd#A8EarningsPerShareTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A9OtherIncomeAndExpenses" xlink:href="bio-20120331.xsd#A9OtherIncomeAndExpenses" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A9OtherIncomeAndExpensesDetails" xlink:href="bio-20120331.xsd#A9OtherIncomeAndExpensesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/A9OtherIncomeAndExpensesTables" xlink:href="bio-20120331.xsd#A9OtherIncomeAndExpensesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:href="bio-20120331.xsd#CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:href="bio-20120331.xsd#CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="bio-20120331.xsd#CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeParenthetical" xlink:href="bio-20120331.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:href="bio-20120331.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:href="bio-20120331.xsd#CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.bio-rad.com/role/DocumentAndEntityInformation" xlink:href="bio-20120331.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A10IncomeTaxes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A10IncomeTaxesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A11SegmentInformation" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A11SegmentInformationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A11SegmentInformationTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A11SegmentProfitReconciliationDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01094b54-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01094b54-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="bio-20120331.xsd#bio_NetCorporateOperatingInterestAndOtherExpenseNotAllocatedToSegments" xlink:label="loc_bio_NetCorporateOperatingInterestAndOtherExpenseNotAllocatedToSegments_9cb3125a-8c70-11e0-bba0-12313b06a4a2" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_bio_NetCorporateOperatingInterestAndOtherExpenseNotAllocatedToSegments_9cb3125a-8c70-11e0-bba0-12313b06a4a2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f216971e-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f216971e-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/A12LegalProceedings" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A12LegalProceedingsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A1BasisOfPresentationAndUseOfEstimatesImmaterialErrorCorrectionsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A1OrganizationConsolidationAndPresentationOfFinancialStatements" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A2Acquisitions" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A2AcquisitionsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A2AcquisitionsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3AmortizedCostAndFairValueOfDebtSecuritiesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_fa17753c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_fa17753c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_fa182608-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_fa182608-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_fa189a48-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_fa189a48-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_fa11281c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_fa13c702-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_fa11281c-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_fa13c702-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_fa144984-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_fa11281c-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_fa144984-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_fa14bb08-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_fa11281c-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_fa14bb08-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3FairValueAndGrossUnrealizedLossesWithUnrealizedLossesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3FairValueInvestmentsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3FairValueMeasurements" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3FairValueMeasurements3ContingentConsiderationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3FairValueMeasurementsFairValueLevelTableDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3FairValueMeasurementsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3ForeignExchangeForwardContractsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A3ShortTermInvestmentsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_fa11281c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_fa11281c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain_09db1640-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain_09db1640-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1_0d531534-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_049c1c6a-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1_0d531534-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOther" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOtherDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOtherIntangibleAssetsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A4IntangibleAssetsGoodwillAndOtherTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A5ProductWarrantyLiability" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A5ProductWarrantyLiabilityDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A5ProductWarrantyLiabilityTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A6LongTermDebt" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A6LongTermDebtDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_efc8f358-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_efc3d2ec-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_efc8f358-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_LongTermDebtCurrent_efc3d2ec-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_efc6161a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_efc8f358-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_efc6161a-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/A6LongTermDebtTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A7NoncontrollingInterest" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A7NoncontrollingInterestDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A7NoncontrollingInterestTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A7NoncontrollingInterestsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A8EarningsPerShare" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A8EarningsPerShareDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_f986d78e-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_f9898fce-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_f986d78e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_f9898fce-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_edb1d10c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_f986d78e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_edb1d10c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/A8EarningsPerShareTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A9OtherIncomeAndExpenses" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A9OtherIncomeAndExpensesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/A9OtherIncomeAndExpensesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_eed459d8-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_eec8615a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_eed459d8-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_Liabilities_eec8615a-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_eec8615a-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_07c49f2a-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AccountsPayableCurrent_07c49f2a-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_080122b0-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_080122b0-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NotesAndLoansPayableCurrent" xlink:label="loc_us-gaap_NotesAndLoansPayableCurrent_f12333b2-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_NotesAndLoansPayableCurrent_f12333b2-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_08069628-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_TaxesPayableCurrent_08069628-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_07fb1514-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_07fb1514-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_faeb4bdc-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e70775a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_faeb4bdc-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_efc6161a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_eec8615a-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_efc6161a-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_faebbfcc-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_eec8615a-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_faebbfcc-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_06160e84-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_eed459d8-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_06160e84-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_00bf81f4-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_06160e84-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_StockholdersEquity_00bf81f4-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_f05708b4-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_06160e84-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_MinorityInterest_f05708b4-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_fa7db8f6-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_edd3f2e6-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fa7db8f6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_Goodwill_edd3f2e6-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_edd1cd86-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fa7db8f6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_edd1cd86-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaap_OtherAssets_0973d714-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fa7db8f6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherAssets_0973d714-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fa7db8f6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e5378c74-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e5378c74-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_f8083a06-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ShortTermInvestments_f8083a06-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_e2791aa2-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_e2791aa2-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_ee7eb460-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_InventoryNet_ee7eb460-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_ee800f7c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee7eb460-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_InventoryRawMaterials_ee800f7c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_ee81d320-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee7eb460-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_InventoryWorkInProcess_ee81d320-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_ee7d60d8-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee7eb460-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_InventoryFinishedGoods_ee7d60d8-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_089fff02-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_089fff02-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_f5cca8ee-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f8ae30dc-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_f5cca8ee-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_f43e00ea-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fa7db8f6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_f43e00ea-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_f43d4286-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_f43e00ea-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_f43d4286-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e2d13566-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_f43e00ea-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e2d13566-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="bio-20120331.xsd#bio_NetBorrowingsPaymentsOnLineOfCreditArrangementsAndNotesPayable" xlink:label="loc_bio_NetBorrowingsPaymentsOnLineOfCreditArrangementsAndNotesPayable_23b39549-36b5-051e-c0b6-00080b26951f" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_bio_NetBorrowingsPaymentsOnLineOfCreditArrangementsAndNotesPayable_23b39549-36b5-051e-c0b6-00080b26951f" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_f3ed9eac-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_f3ed9eac-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_f56fd81c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_f56fd81c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_f3de7e68-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_f3de7e68-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_e7619774-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_e7619774-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities" xlink:label="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities_f88c5ffc-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0848d20-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities_f88c5ffc-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_05aaf4d2-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProfitLoss_05aaf4d2-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaap_DepreciationAndAmortization_e83bd45c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_DepreciationAndAmortization_e83bd45c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_eaf41c9a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ShareBasedCompensation_eaf41c9a-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_GainLossOnSaleOfDerivatives" xlink:label="loc_us-gaap_GainLossOnSaleOfDerivatives_e3532620-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_GainLossOnSaleOfDerivatives_e3532620-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_GainLossOnSaleOfSecuritiesNet" xlink:label="loc_us-gaap_GainLossOnSaleOfSecuritiesNet_f0e777f0-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_GainLossOnSaleOfSecuritiesNet_f0e777f0-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities" xlink:label="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities_feb636d2-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="6" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities_feb636d2-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_e5a3a9a4-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="7" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_e5a3a9a4-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_e5ba7986-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="8" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_e5ba7986-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_0dad98b0-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="9" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_0dad98b0-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndOtherOperatingLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndOtherOperatingLiabilities_0a112686-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="10" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndOtherOperatingLiabilities_0a112686-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_e5b73794-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="11" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_e5b73794-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_f1a5bf8a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="12" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f0868ac6-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_f1a5bf8a-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f4a4611e-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f4a4611e-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_f40b02da-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_f40b02da-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="bio-20120331.xsd#bio_PaymentsForAcquisitionsNetOfCashReceivedAndLongTermInvestments" xlink:label="loc_bio_PaymentsForAcquisitionsNetOfCashReceivedAndLongTermInvestments_331efb6a-7a8c-66cd-41d3-00080b55104d" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_bio_PaymentsForAcquisitionsNetOfCashReceivedAndLongTermInvestments_331efb6a-7a8c-66cd-41d3-00080b55104d" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_f489f658-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_f489f658-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="bio-20120331.xsd#bio_PurchasesOfMarketableSecuritiesAndInvestments" xlink:label="loc_bio_PurchasesOfMarketableSecuritiesAndInvestments_7770bf73-725a-ede3-7ad8-00080b4f2bee" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_bio_PurchasesOfMarketableSecuritiesAndInvestments_7770bf73-725a-ede3-7ad8-00080b4f2bee" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_f3fc2b5c-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_f3fc2b5c-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_f3f1ab00-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_f3f1ab00-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_0b5f2c4a-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="8" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f085995e-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_PaymentsForProceedsFromDerivativeInstrumentInvestingActivities_0b5f2c4a-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeParenthetical" xlink:type="extended" />
  <calculationLink xlink:role="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_e63cc850-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_0613007c-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_e63cc850-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_0613007c-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_06132da4-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_e63cc850-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_06132da4-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecrease" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecrease_f1d30b98-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecrease" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecrease_f1c61424-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecrease_f1d30b98-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPeriodIncreaseDecrease_f1c61424-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPeriodIncreaseDecrease" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPeriodIncreaseDecrease_f1befcd4-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecrease_f1d30b98-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPeriodIncreaseDecrease_f1befcd4-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_f1e17ab6-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecrease_f1d30b98-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_f1e17ab6-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax_00320892-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecrease_f1d30b98-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax_00320892-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_f0af6c2a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_05aaf4d2-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f0af6c2a-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ProfitLoss_05aaf4d2-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_05aaf4d2-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaap_GrossProfit_ec7be2aa-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_GrossProfit_ec7be2aa-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_us-gaap_SalesRevenueNet_f679139a-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_ec7be2aa-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_SalesRevenueNet_f679139a-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_e6ce98a2-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_ec7be2aa-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_CostOfGoodsSold_e6ce98a2-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f777bd46-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f777bd46-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_f9ff4160-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_f1959cb8-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_f9ff4160-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_ede3c4f0-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_InterestExpense_ede3c4f0-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01094b54-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_01094b54-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f216971e-2585-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ffc350a0-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f216971e-2585-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_0106fc64-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_05aaf4d2-2586-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_0106fc64-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_05ab7ee8-2586-11e0-bc05-7b821c07cce9" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f0af6c2a-2585-11e0-bc05-7b821c07cce9" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_05ab7ee8-2586-11e0-bc05-7b821c07cce9" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.bio-rad.com/role/DocumentAndEntityInformation" xlink:type="extended" />
</linkbase>
