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10. Segment Profit Reconciliation (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Mar. 31, 2017
Sep. 30, 2018
Sep. 30, 2017
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Income before income taxes $ 350,131 $ 30,588   $ 1,553,906 $ 51,855
Unrealized Gain on Securities 318,007 0   1,420,339 0
Operating Segments [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Income before income taxes 32,700 35,800   112,600 54,600
Corporate, Non-Segment [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Income before income taxes (2,500) (2,900)   (6,700) (8,500)
Segment Reconciling Items [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Unrealized Gain on Securities 318,000 0   1,420,300 0
Foreign Currency Gain (Loss) [Member] | Segment Reconciling Items [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Income before income taxes (700) (3,400)   (1,900) (7,700)
Other Nonoperating Income (Expense) [Member] | Segment Reconciling Items [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Income before income taxes 2,600 1,100   29,600 13,500
Life Science [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Business Combination, Separately Recognized Transactions, Additional Disclosures, Acquisition Cost Expensed     $ 10,000    
Income before income taxes 10,200 5,300   25,700 (36,400)
Clinical Diagnostics [Member]          
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]          
Income before income taxes $ 22,400 $ 30,300   $ 86,800 $ 90,400