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1. Significant Accounting Policies Details (Details) $ in Thousands | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Jan. 01, 2018 USD ($) | Dec. 31, 2015 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Deferred Tax Assets, Net, Noncurrent |  |  |  | $ 5,200 |
Interest expense | $ 23,962 | $ 23,014 | $ 23,380 |  |
Selling, general and administrative expense | 834,783 | 806,790 | 814,697 |  |
Research and development expense | 199,196 | 250,157 | 205,708 |  |
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit) | (119,000) | (70,000) |  |  |
Stockholders' Equity Attributable to Parent | 4,020,331 | 2,930,250 | 2,579,160 |  | $ 2,485,029
Restricted investments | 5,560 | 5,560 |  |  |
Retained earnings | 3,722,073 | 1,830,439 |  |  |
Prepaid Taxes | (5,500) |  |  | (22,800) |
Accumulated other comprehensive (loss) income | (46,958) | 738,794 |  |  |
Other (income) expense, net | 36,593 | 10,697 | 13,764 |  |
Deferred Tax Assets, Gross | $ 147,100 | 145,600 |  |  |
Document Fiscal Year Focus | 2018 |  |  |  |
Unrealized Gain on Securities | $ 606,230 | 0 | 0 |  |
Deferred Income Tax Expense (Benefit) | 120,900 | (84,800) | (51,200) |  |
Cost of Goods and Services Sold | 1,066,264 | 972,450 | 929,744 |  |
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit), Increase | (49,000) |  |  |  |
Tax Cuts and Jobs Act, Income Tax Expense (Benefit) Composition | (169,000) |  |  |  |
Tax Cuts and Jobs Act, Income Tax Expense, Composition | 50,000 |  |  |  |
Accounting Standards Update 2016-01 [Member] |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Other assets | 600 |  |  |  |
Accumulated other comprehensive (loss) income |  |  |  | 679,200 |
Adjustments for New Accounting Pronouncement [Member] |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Interest expense |  | 1,100 | 1,438 |  |
Selling, general and administrative expense |  | 2,152 | 2,027 |  |
Research and development expense |  | 144 | 156 |  |
Stockholders' Equity Attributable to Parent |  |  |  | 864,500 |
Retained earnings |  |  |  | 1,543,700 |
Deferred Income Tax Assets, Net |  |  |  | 232,900 |
Investments |  |  |  | 1,097,400 |
Other (income) expense, net |  | 1,500 | 1,086 |  |
Deferred Income Tax Expense (Benefit) | 133,900 |  |  |  |
Cost of Goods and Services Sold |  | 304 | $ 341 |  |
Restricted Cash | $ 2,600 | $ 1,200 |  |  |
Accounting Standards Update 2016-16 [Member] |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Retained earnings |  |  |  | $ (17,600) |
541714 Research and Development in Biotechnology (except Nanobiotechnology) [Member] |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Entity Number of Employees | 800 |  |  |  |

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