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1. Significant Accounting Policies Details (Details)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Jan. 01, 2018
USD ($)
Dec. 31, 2015
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Deferred Tax Assets, Net, Noncurrent       $ 5,200  
Interest expense $ 23,962 $ 23,014 $ 23,380    
Selling, general and administrative expense 834,783 806,790 814,697    
Research and development expense 199,196 250,157 205,708    
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit) (119,000) (70,000)      
Stockholders' Equity Attributable to Parent 4,020,331 2,930,250 2,579,160   $ 2,485,029
Restricted investments 5,560 5,560      
Retained earnings 3,722,073 1,830,439      
Prepaid Taxes (5,500)     (22,800)  
Accumulated other comprehensive (loss) income (46,958) 738,794      
Other (income) expense, net 36,593 10,697 13,764    
Deferred Tax Assets, Gross $ 147,100 145,600      
Document Fiscal Year Focus 2018        
Unrealized Gain on Securities $ 606,230 0 0    
Deferred Income Tax Expense (Benefit) 120,900 (84,800) (51,200)    
Cost of Goods and Services Sold 1,066,264 972,450 929,744    
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit), Increase (49,000)        
Tax Cuts and Jobs Act, Income Tax Expense (Benefit) Composition (169,000)        
Tax Cuts and Jobs Act, Income Tax Expense, Composition 50,000        
Accounting Standards Update 2016-01 [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Other assets 600        
Accumulated other comprehensive (loss) income       679,200  
Adjustments for New Accounting Pronouncement [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Interest expense   1,100 1,438    
Selling, general and administrative expense   2,152 2,027    
Research and development expense   144 156    
Stockholders' Equity Attributable to Parent       864,500  
Retained earnings       1,543,700  
Deferred Income Tax Assets, Net       232,900  
Investments       1,097,400  
Other (income) expense, net   1,500 1,086    
Deferred Income Tax Expense (Benefit) 133,900        
Cost of Goods and Services Sold   304 $ 341    
Restricted Cash $ 2,600 $ 1,200      
Accounting Standards Update 2016-16 [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Retained earnings       $ (17,600)  
541714 Research and Development in Biotechnology (except Nanobiotechnology) [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Entity Number of Employees 800