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1. Significant Accounting Policies Details (Details) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2019 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Interest expense |  | $ 23,416 | $ 23,962 | $ 23,014 |
Selling, general and administrative expense |  | 824,625 | 834,783 | 806,790 |
Research and development expense |  | 202,710 | 199,196 | 250,157 |
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit) |  |  |  | 70,000 |
Stockholders' Equity Attributable to Parent | $ 5,755,057 | 5,755,057 | 4,020,331 | 2,930,250 | $ 2,579,160
Restricted investments | 5,560 | 5,560 | 5,560 |  |
Retained earnings | 5,470,779 | 5,470,779 | 3,722,073 |  |
Prepaid Taxes | (5,400) | (5,400) |  |  |
Accumulated other comprehensive (loss) income | (87,348) | (87,348) | (46,958) |  |
Other (income) expense, net |  | 26,094 | 36,593 | 10,697 |
Deferred Tax Assets, Gross | 205,200 | $ 205,200 | 147,100 |  |
Document Fiscal Year Focus |  | 2019 |  |  |
Unrealized Gain on Securities | 646,000 | $ 2,030,987 | 606,230 | 0 |
Deferred Income Tax Expense (Benefit) |  | 450,200 | 120,900 | (84,800) |
Cost of Goods and Services Sold |  | 1,054,663 | 1,066,264 | $ 972,450 |
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit), Increase |  |  | $ (49,000) |  |
Adjustments for New Accounting Pronouncement [Member] |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Capitalized Cloud Computing Arrangements | $ 3,100 | $ 3,100 |  |  |
541714 Research and Development in Biotechnology (except Nanobiotechnology) [Member] |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Entity Number of Employees | 780 | 780 |  |  |

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