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1. Significant Accounting Policies Details (Details)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2019
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Interest expense   $ 23,416 $ 23,962 $ 23,014  
Selling, general and administrative expense   824,625 834,783 806,790  
Research and development expense   202,710 199,196 250,157  
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit)       70,000  
Stockholders' Equity Attributable to Parent $ 5,755,057 5,755,057 4,020,331 2,930,250 $ 2,579,160
Restricted investments 5,560 5,560 5,560    
Retained earnings 5,470,779 5,470,779 3,722,073    
Prepaid Taxes (5,400) (5,400)      
Accumulated other comprehensive (loss) income (87,348) (87,348) (46,958)    
Other (income) expense, net   26,094 36,593 10,697  
Deferred Tax Assets, Gross 205,200 $ 205,200 147,100    
Document Fiscal Year Focus   2019      
Unrealized Gain on Securities 646,000 $ 2,030,987 606,230 0  
Deferred Income Tax Expense (Benefit)   450,200 120,900 (84,800)  
Cost of Goods and Services Sold   1,054,663 1,066,264 $ 972,450  
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit), Increase     $ (49,000)    
Adjustments for New Accounting Pronouncement [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Capitalized Cloud Computing Arrangements $ 3,100 $ 3,100      
541714 Research and Development in Biotechnology (except Nanobiotechnology) [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Entity Number of Employees 780 780