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1. Significant Accounting Policies Details (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Interest expense   $ 21,861 $ 23,416 $ 23,962  
Selling, general and administrative expense   800,267 824,625 834,783  
Research and development expense   226,598 202,710 199,196  
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit)         $ 70,000
Stockholders' Equity Attributable to Parent $ 9,879,940 9,879,940 5,755,057 4,020,331 $ 2,930,250
Restricted investments 5,560 5,560 5,560    
Retained earnings 9,268,012 9,268,012 5,470,779    
Prepaid Taxes (5,800) (5,800)      
Accumulated other comprehensive (loss) income 282,456 282,456 (87,348)    
Other (income) expense, net   24,488 26,094 36,593  
Deferred Tax Assets, Gross 247,000 247,000 205,200    
Unrealized Gain on Securities   4,495,825 2,030,987 606,230  
Deferred Income Tax Expense (Benefit)   979,000 450,200 120,900  
Cost of Goods and Services Sold   1,107,804 1,054,663 1,066,264  
Tax Cuts and Jobs Act, Change in Tax Rate, Income Tax Expense (Benefit), Increase       (49,000)  
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)   0 0 10,500  
Goodwill, Impairment Loss   0 0 282,000  
Accounts Receivable, Allowance for Credit Loss, Period Increase (Decrease)   1,200 (1,200) 3,900  
Accounts Receivable, Allowance for Credit Loss, Writeoff   (1,600) (6,600) (2,700)  
Accounts Receivable, Allowance for Credit Loss, Recovery   0 1,300 0  
Litigation Settlement, Amount Awarded from Other Party 35,300        
Trading Revenue [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Litigation Settlement, Amount Awarded from Other Party $ 32,300        
Clinical Diagnostics [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Interest expense   13,800 15,900 16,700  
Goodwill, Impairment Loss       276,100  
Life Science [Member]          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Interest expense   $ 8,000 $ 7,400 7,200  
Goodwill, Impairment Loss       $ 5,900