9. Share-based Compensation (Details) - USD ($)	12 Months Ended
Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Payment Arrangement, Exercise of Option, Tax Benefit	$ 11,200,000	$ 5,400,000	$ 5,400,000
Share-based Compensation Expense	41,600,000	35,600,000	27,800,000
Share-based Payment Arrangement, Expense, Tax Benefit	6,000,000.0	5,600,000	4,400,000
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Expense	6,400,000	4,800,000	3,500,000
cost of goods sold [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Expense	3,400,000	2,900,000	2,300,000
Selling, General and Administrative Expenses [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Expense	$ 31,800,000	$ 27,900,000	22,000,000.0
2011 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Shares Authorized	1,300,000
Stock Option and Award Plans [Member] \| Incentive Award Plan 2017 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Shares Authorized	2,108,050
Number of Shares Available for Grant	1,451,617
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted Average Remaining Contractual Term (in years) - Outstanding	4 years 7 months 20 days
Aggregate Intrinsic Value (in millions) - Outstanding	$ 110.2
Options - Weighted-Average Exercise Price	$ 196.29	$ 162.23
Options Granted - Weighted Average Exercise Price	524.30
Options Exercised - Weighted Average Exercise Price	112.96
Options Granted Term		10
Options Forfeitured/expired - Weighted Average Exercise Price	$ 269.64
Options - Shares Vested and Expected to Vest	73,126
Options Vested and Expected to Vest - Weighted Average Exercise Price	$ 364.07
Options Vested and Expected to Vest - Weighted Average Remaining Contractual Term (in years)	8 years 4 months 6 days
Options Vested and Expected to Vest - Aggregate Intrinsic Value (in millions)	$ 16.0
Weighted Average Exercise Price - Options Exercisable	$ 138.42
Weighted Average Remaining Contractual Term (in years) - Exercisable	3 years 4 months 9 days
Options Exercisable Aggregate Intrinsic Value (in millions)	$ 94.2
Options, Exercises in Period, Total Intrinsic Value	24,000,000	$ 12,000,000	8,000,000
Cash Received from Exercise of Stock Options	3,800,000	$ 2,600,000	$ 500,000
Total unrecognized compensation cost from stock options	$ 7,000,000.0
Options Number Exercisable	211,997
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage	25.00%	20.00%
Weighted average fair value of options granted, period for recognition	3 years
Expected Volatility	27.00%	22.00%	22.00%
Risk Free Interest Rate	0.31%	1.69%	2.85%
Expected life (in years)	7 years 4 months 24 days	7 years 6 months	7 years 7 months 6 days
Expected dividend	$ 0	$ 0	$ 0
Weighted average fair value of options granted	$ 153.32	$ 93.96	$ 105.94
Expected dividend yield	0.00%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Outstanding beginning of period	344,522
Options - Shares Granted	22,527
Options - Shares Exercised	(66,085)
Options - Shares Forfeitures/expired	(15,841)
Outstanding end of period	285,123	344,522
Employee Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Shares Available for Grant	551,983
Cash Received from Exercise of Stock Options	$ 16,400,000	$ 14,300,000	$ 13,600,000
Stock Issued During Period, Shares, Employee Stock Purchase Plans	47,548	58,717	63,464
Employee Contribution Rate - Maximum	10.00%
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Employee Contribution Amount	$ 25,000
Employee Purchase Price Discount from Market Price	85.00%
Expected Volatility	41.00%	31.00%	27.00%
Risk Free Interest Rate	0.50%	2.25%	1.82%
Expected life (in years)	3 months	3 months	3 months
Expected dividend	$ 0	$ 0	$ 0
Expected dividend yield	0.00%
Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted Average Price of Shares Purchased	$ 94.93	$ 60.39	$ 55.04

Share-based Compensation Arrangement by Share-based Payment Award, Maximum Employee Contribution Amount

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Amount of tax benefit for recognition of expense of award under share-based payment arrangement.

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Amount of tax benefit from exercise of option under share-based payment arrangement.

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Amount of cash inflow from exercise of option under share-based payment arrangement.

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Discount rate from fair value on purchase date that participants pay for shares.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Disclosure of the weighted average expected dividend for an entity using a valuation technique with different dividend rates during the contractual term.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The highest percentage of annual salary that an employee is permitted to utilize with respect to the plan.

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Number of shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Net number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Per share weighted-average price paid for shares purchased on open market for issuance under share-based payment arrangement.

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Description of terms of award under share-based payment arrangement.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Percentage of vesting of award under share-based payment arrangement.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of shares issued during the period as a result of an employee stock purchase plan.

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-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 2
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