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1. Basis of Presentation and Use of Estimates Organization, Consolidation and Presentation of Financial Statements (Details) - USD ($) $ in Thousands | 3 Months Ended |  |
--- | --- | --- | ---
Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020
Organization, Consolidation and Presentation of Financial Statements [Line Items] |  |  |  |
Net sales | $ 700,062 | $ 726,796 |  |
Cost of goods sold | 296,502 | 326,169 |  |
Deferred Revenue | 59,400 |  | $ 71,000 |
Retained earnings | 10,137,628 |  | 13,507,241 |
Accumulated other comprehensive loss | (307,856) |  | (175,553) |
Total stockholders' equity | $ 10,182,916 | $ 10,609,059 | 13,667,134 | $ 9,879,940
Revenue Allocation Percent To Lease Elements | 2.00% | 2.00% |  |
Additional paid-in-capital | $ 459,431 |  | 441,733 |
Selling, general and administrative expense | 197,594 | $ 225,853 |  |
Research and Development Expense | 62,543 | 73,912 |  |
Interest expense | 4,048 | 398 |  |
Other Nonoperating Income (Expense) | 32,597 | 17,407 |  |
Deferred Revenue, Current | 59,300 |  | $ 50,900 |
Europe [Member] |  |  |  |
Organization, Consolidation and Presentation of Financial Statements [Line Items] |  |  |  |
Net sales | 218,900 | 247,700 |  |
Asia Pacific [Member] |  |  |  |
Organization, Consolidation and Presentation of Financial Statements [Line Items] |  |  |  |
Net sales | 160,900 | 168,900 |  |
UNITED STATES |  |  |  |
Organization, Consolidation and Presentation of Financial Statements [Line Items] |  |  |  |
Net sales | 282,500 | 271,400 |  |
Americas [Member] |  |  |  |
Organization, Consolidation and Presentation of Financial Statements [Line Items] |  |  |  |
Net sales | $ 37,800 | $ 38,800 |  |

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