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10. Segment Information Segment Profit Reconciliations (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest | $ (1,222,880) | $ 1,156,775 | $ (5,593,897) | $ 2,453,978
Marketable Securities, Unrealized Gain (Loss) | (1,338,190) | 1,030,691 | (5,883,307) | 2,210,094
Net sales | 691,099 | 715,931 | 1,391,161 | 1,442,727
Life Science [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | 50,800 | 64,600 | 137,700 | 166,900
Net sales | 322,400 | 334,200 | 669,500 | 700,700
Other Segments [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | (500) | (300) | (800) | (200)
Net sales | 900 | 1,500 | 2,200 | 3,200
Clinical Diagnostics [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | 59,200 | 60,100 | 112,000 | 58,200
Net sales | 367,800 | 380,200 | 719,500 | 738,800
Operating Segments [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | 109,500 | 124,400 | 248,900 | 224,900
Segment Reconciling Items [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Marketable Securities, Unrealized Gain (Loss) | (1,338,200) | 1,030,700 | (5,883,300) | 2,210,100
Foreign Currency Gain (Loss) [Member] | Segment Reconciling Items [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | (900) | 1,800 | 1,200 | 1,700
Other Nonoperating Income (Expense) [Member] | Segment Reconciling Items [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | $ 6,700 | $ (100) | $ 39,300 | $ 17,300

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