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10. Segment Information Segment Profit Reconciliations (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest $ (1,222,880) $ 1,156,775 $ (5,593,897) $ 2,453,978
Marketable Securities, Unrealized Gain (Loss) (1,338,190) 1,030,691 (5,883,307) 2,210,094
Net sales 691,099 715,931 1,391,161 1,442,727
Life Science [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income before income taxes 50,800 64,600 137,700 166,900
Net sales 322,400 334,200 669,500 700,700
Other Segments [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income before income taxes (500) (300) (800) (200)
Net sales 900 1,500 2,200 3,200
Clinical Diagnostics [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income before income taxes 59,200 60,100 112,000 58,200
Net sales 367,800 380,200 719,500 738,800
Operating Segments [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income before income taxes 109,500 124,400 248,900 224,900
Segment Reconciling Items [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Marketable Securities, Unrealized Gain (Loss) (1,338,200) 1,030,700 (5,883,300) 2,210,100
Foreign Currency Gain (Loss) [Member] | Segment Reconciling Items [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income before income taxes (900) 1,800 1,200 1,700
Other Nonoperating Income (Expense) [Member] | Segment Reconciling Items [Member]        
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]        
Income before income taxes $ 6,700 $ (100) $ 39,300 $ 17,300