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4. Intangible Assets, Goodwill and Other (Tables) | 9 Months Ended
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Sep. 30, 2022
Goodwill and Intangible Assets Disclosure [Abstract] |
Changes to goodwill by segment | oodwill by segment are as follows (in millions):
| Life Science |  | Clinical Diagnostics |  | Total
Balances as of December 31, 2021: |  |  |  |  |
Goodwill | $ | 333.3 |  |  | $ | 349.2 |  |  | $ | 682.5 |
Accumulated impairment losses | (41.8) |  |  | (293.4) |  |  | (335.2) |
Goodwill, net | 291.5 |  |  | 55.8 |  |  | 347.3 |
Acquisitions (see Note 2) | — |  |  | 55.9 |  |  | 55.9 |
Currency fluctuations | — |  |  | (3.6) |  |  | (3.6) |
Period increase, net | — |  |  | 52.3 |  |  | 52.3 |
Balances as of September 30, 2022: |  |  |  |  |
Goodwill | 333.3 |  |  | 401.5 |  |  | 734.8 |
Accumulated impairment losses | (41.8) |  |  | (293.4) |  |  | (335.2) |
Goodwill, net | $ | 291.5 |  |  | $ | 108.1 |  |  | $ | 399.6 |
Schedule of identifiable purchased intangible assets with definite lives | Information regarding our identifiable purchased intangible assets with finite and indefinite lives is as follows (in millions):
| September 30, 2022
| Weighted-Average Remaining Amortization Period (years) |  | Purchase Price |  | Accumulated Amortization |  | Net Carrying Amount
Customer relationships/lists | 5.13 |  | $ | 99.2 |  |  | $ | (83.1) |  |  | $ | 16.1 |
Know how | 3.00 |  | 158.9 |  |  | (145.5) |  |  | 13.4 |
Developed product technology | 13.06 |  | 206.8 |  |  | (115.6) |  |  | 91.2 |
Licenses | 6.11 |  | 58.2 |  |  | (37.0) |  |  | 21.2 |
Tradenames | 6.81 |  | 5.9 |  |  | (4.2) |  |  | 1.7 |
Covenants not to compete | 3.27 |  | 6.4 |  |  | (3.7) |  |  | 2.7 |
Total finite-lived intangible assets |  |  | 535.4 |  |  | (389.1) |  |  | 146.3 |
In-process research and development |  |  | 178.8 |  |  | — |  |  | 178.8 |
Total purchased intangible assets |  |  | $ | 714.2 |  |  | $ | (389.1) |  |  | $ | 325.1 |
| December 31, 2021
| Weighted-Average Remaining Amortization Period (years) |  | Purchase Price |  | Accumulated Amortization |  | Net Carrying Amount
Customer relationships/lists | 5.27 |  | $ | 111.8 |  |  | $ | (90.7) |  |  | $ | 21.1 |
Know how | 3.75 |  | 171.6 |  |  | (154.9) |  |  | 16.7 |
Developed product technology | 13.42 |  | 215.6 |  |  | (115.6) |  |  | 100.0 |
Licenses | 6.79 |  | 64.9 |  |  | (40.6) |  |  | 24.3 |
Tradenames | 7.33 |  | 6.3 |  |  | (4.4) |  |  | 1.9 |
Covenants not to compete | 3.78 |  | 6.5 |  |  | (2.9) |  |  | 3.6 |
Total finite-lived intangible assets |  |  | 576.7 |  |  | (409.1) |  |  | 167.6 |
In-process research and development |  |  | 86.3 |  |  | — |  |  | 86.3 |
Total purchased intangible assets |  |  | $ | 663.0 |  |  | $ | (409.1) |  |  | $ | 253.9 |
Finite-lived Intangible Assets Amortization Expense [Table Text Block] | Amortization expense related to purchased intangible assets is as follows (in millions):
| Three Months Ended |  | Nine Months Ended
| September 30, |  | September 30,
| 2022 |  | 2021 |  | 2022 |  | 2021
Amortization expense | $ | 6.2 |  |  | $ | 7.3 |  |  | $ | 18.8 |  |  | $ | 21.7 |

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