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10. Segment Information Segment Profit Reconciliations (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest | $ (209,168) | $ 5,022,226 | $ (5,803,065) | $ 7,476,204
Marketable Securities, Unrealized Gain (Loss) | (288,999) | 4,868,659 | (6,172,306) | 7,078,753
Net sales | 680,800 | 747,049 | 2,071,961 | 2,189,776
Life Science [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | 45,700 | 105,800 | 183,500 | 272,700
Net sales | 317,900 | 373,500 | 987,500 | 1,074,200
Other Segments [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | (600) | (200) | (1,500) | (400)
Net sales | 1,000 | 1,300 | 3,100 | 4,600
Clinical Diagnostics [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | 36,000 | 50,700 | 148,000 | 108,900
Net sales | 361,900 | 372,200 | 1,081,400 | 1,111,000
Operating Segments [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | 81,100 | 156,300 | 330,000 | 381,200
Segment Reconciling Items [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Marketable Securities, Unrealized Gain (Loss) | (289,000) | 4,868,700 | (6,172,300) | 7,078,800
Foreign Currency Gain (Loss) [Member] | Segment Reconciling Items [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | (4,400) | (2,200) | (3,100) | (500)
Other Nonoperating Income (Expense) [Member] | Segment Reconciling Items [Member] |  |  |  |
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items] |  |  |  |
Income before income taxes | $ 3,100 | $ (600) | $ 42,300 | $ 16,700

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