10. Segment Information Segment Profit Reconciliations (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest	$ (209,168)	$ 5,022,226	$ (5,803,065)	$ 7,476,204
Marketable Securities, Unrealized Gain (Loss)	(288,999)	4,868,659	(6,172,306)	7,078,753
Net sales	680,800	747,049	2,071,961	2,189,776
Life Science [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income before income taxes	45,700	105,800	183,500	272,700
Net sales	317,900	373,500	987,500	1,074,200
Other Segments [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income before income taxes	(600)	(200)	(1,500)	(400)
Net sales	1,000	1,300	3,100	4,600
Clinical Diagnostics [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income before income taxes	36,000	50,700	148,000	108,900
Net sales	361,900	372,200	1,081,400	1,111,000
Operating Segments [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income before income taxes	81,100	156,300	330,000	381,200
Segment Reconciling Items [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Marketable Securities, Unrealized Gain (Loss)	(289,000)	4,868,700	(6,172,300)	7,078,800
Foreign Currency Gain (Loss) [Member] \| Segment Reconciling Items [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income before income taxes	(4,400)	(2,200)	(3,100)	(500)
Other Nonoperating Income (Expense) [Member] \| Segment Reconciling Items [Member]
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Income before income taxes	$ 3,100	$ (600)	$ 42,300	$ 16,700

Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest.

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