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4. Intangible Assets, Goodwill and Other (Tables) | 3 Months Ended
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Mar. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract] |
Changes to goodwill by segment | Changes to goodwill by segment are as follows (in millions):
| Life Science |  | Clinical Diagnostics |  | Total
Balances as of December 31, 2022: |  |  |  |  |
Goodwill | $ | 333.3 |  |  | $ | 408.4 |  |  | $ | 741.7 |
Accumulated impairment losses | (41.8) |  |  | (293.4) |  |  | (335.2) |
Goodwill, net | 291.5 |  |  | 115.0 |  |  | 406.5 |
Acquisitions (see Note 2) | — |  |  | 0.4 |  |  | 0.4 |
Foreign currency adjustments | — |  |  | 0.9 |  |  | 0.9 |
Period increase, net | — |  |  | 1.3 |  |  | 1.3 |
Balances as of March 31, 2023: |  |  |  |  |
Goodwill | 333.3 |  |  | 409.7 |  |  | 743.0 |
Accumulated impairment losses | (41.8) |  |  | (293.4) |  |  | (335.2) |
Goodwill, net | $ | 291.5 |  |  | $ | 116.3 |  |  | $ | 407.8 |
Schedule of identifiable purchased intangible assets with definite lives | Information regarding our identifiable purchased intangible assets with finite and indefinite lives is as follows (in millions):
| March 31, 2023
| Weighted-Average Remaining Amortization Period (years) |  | Purchase Price |  | Accumulated Amortization |  | Net Carrying Amount
Customer relationships/lists | 5.0 |  | $ | 105.7 |  |  | $ | (92.2) |  |  | $ | 13.5 |
Know how | 2.5 |  | 167.3 |  |  | (156.1) |  |  | 11.2 |
Developed product technology | 12.7 |  | 211.9 |  |  | (124.6) |  |  | 87.3 |
Licenses | 5.6 |  | 59.0 |  |  | (39.5) |  |  | 19.5 |
Tradenames | 6.3 |  | 6.1 |  |  | (4.5) |  |  | 1.6 |
Covenants not to compete | 3.0 |  | 6.4 |  |  | (4.3) |  |  | 2.1 |
Total finite-lived intangible assets |  |  | 556.4 |  |  | (421.2) |  |  | 135.2 |
In-process research and development |  |  | 192.6 |  |  | — |  |  | 192.6 |
Total purchased intangible assets |  |  | $ | 749.0 |  |  | $ | (421.2) |  |  | $ | 327.8 |
| December 31, 2022
| Weighted-Average Remaining Amortization Period (years) |  | Purchase Price |  | Accumulated Amortization |  | Net Carrying Amount
Customer relationships/lists | 5.0 |  | $ | 104.7 |  |  | $ | (89.9) |  |  | $ | 14.8 |
Know how | 2.8 |  | 166.2 |  |  | (153.9) |  |  | 12.3 |
Developed product technology | 12.8 |  | 211.1 |  |  | (121.6) |  |  | 89.5 |
Licenses | 5.8 |  | 59.0 |  |  | (38.5) |  |  | 20.5 |
Tradenames | 6.6 |  | 6.1 |  |  | (4.5) |  |  | 1.6 |
Covenants not to compete | 3.1 |  | 6.4 |  |  | (4.0) |  |  | 2.4 |
Total finite-lived intangible assets |  |  | 553.5 |  |  | (412.4) |  |  | 141.1 |
In-process research and development |  |  | 191.0 |  |  | — |  |  | 191.0 |
Total purchased intangible assets |  |  | $ | 744.5 |  |  | $ | (412.4) |  |  | $ | 332.1 |
Finite-lived Intangible Assets Amortization Expense [Table Text Block] | Amortization expense related to purchased intangible assets is as follows (in millions):
| Three Months Ended |  |
| March 31, |  |
| 2023 |  | 2022 |  |  |  |
Amortization expense | $ | 6.0 |  |  | $ | 6.3 |  |  |  |  |

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