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Segment Information (Tables)
12 Months Ended
Dec. 31, 2023
Segment Reporting [Abstract]  
Information regarding industry segments
Information regarding industry segments at December 31, 2023, 2022, and 2021 and for the years then ended is as follows (in millions):

Life
Science
Clinical
Diagnostics
Other
Operations
Net sales 2023$1,178.4 $1,489.3 $3.6 
 20221,347.2 1,451.0 4.0 
20211,400.8 1,515.9 5.8 
Depreciation and amortization2023$62.8 $83.1 $— 
202257.9 79.4 — 
202154.8 82.8 — 
Operating profit (loss)2023$108.9 $229.6 $(0.7)
 2022266.8 217.7 (1.9)
2021319.7 181.8 (1.2)
Segment assets2023$287.1 $493.1 $0.3 
2022269.9 448.8 0.6 
2021207.7 363.5 1.0 
Reconciliation of segment profit to consolidated income before taxes
The following reconciles total operating profit to consolidated income (loss) before income taxes (in millions):
Year Ended December 31,
 202320222021
Total operating profit$337.8 $482.6 $500.3 
Interest expense(49.3)(38.1)(1.5)
Foreign currency exchange gains (losses), net7.3 0.2 (2.7)
Gains (losses) from change in fair market value of equity securities and loan receivable(1,252.3)(5,193.6)4,926.2 
Other income, net106.4 44.6 26.8 
Consolidated income (loss) before income taxes$(850.1)$(4,704.3)$5,449.1 
Reconciliation of Assets from Segment to Consolidated
The following reconciles total segment assets to consolidated total assets (in millions):
 December 31,
 20232022
Total segment assets$780.5 $719.3 
Cash, short-term investments and other current assets2,267.8 2,438.7 
Property, plant and equipment, net, and operating lease right-of-use assets723.7 679.6 
Goodwill, net413.6 406.5 
Other long-term assets8,113.5 9,257.6 
Total assets$12,299.1 $13,501.7 
Net sales and assets to external customers by geographic area
The following presents net sales to external customers by geographic region based primarily on the location of the use of the product or service (in millions):
 Year Ended December 31,
 202320222021
United States$1,121.9 $1,155.5 $1,130.6 
Europe819.8 851.9 946.9 
Asia563.0 639.4 688.4 
Other (primarily Canada and Latin America)166.6 155.4 156.6 
Total net sales$2,671.3 $2,802.2 $2,922.5 

The following presents Property, plant and equipment, net, Operating lease right-of-use assets and Other assets, excluding deferred income taxes, by geographic region based upon the location of the asset (in millions):
 December 31,
 20232022
United States$477.3 $465.7 
Europe197.0 183.7 
Asia82.7 63.8 
Other (primarily Canada and Latin America)19.1 15.6 
Total Property, plant and equipment, net, Operating lease right-of-use assets and Other assets, excluding deferred income taxes$776.1 $728.8