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Quarterly Financial Data (Unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2023
Sep. 30, 2023
Jun. 30, 2023
Mar. 31, 2023
Dec. 31, 2022
Sep. 30, 2022
Jun. 30, 2022
Mar. 31, 2022
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Quarterly Financial Data [Abstract]                      
Income from operations                 $ 337,796 $ 482,616 $ 500,336
Research and development expense                 247,427 256,889 260,638
Cost of goods sold                 1,244,316 1,234,919 1,284,449
Selling, general and administrative expense                 $ 841,723 $ 827,825 $ 877,122
Net income (loss) per diluted share (in dollars per share) $ 12.14 $ 3.64 $ (39.59) $ 2.32 $ 27.78 $ (5.48) $ (31.05) $ (112.50) $ (21.82) $ (121.79) $ 140.83
Net income (loss) per basic share (in dollars per share) $ 12.15 $ 3.65 $ (39.59) $ 2.33 $ 27.89 $ (5.48) $ (31.05) $ (112.50) $ (21.82) $ (121.79) $ 142.61
Net income (loss) $ 349,700 $ 106,300 $ (1,162,300) $ 69,000 $ 827,700 $ (162,800) $ (925,100) $ (3,367,300) $ (637,324) $ (3,627,535) $ 4,254,257
Gross Profit 366,300 335,700 362,500 362,400 397,100 372,600 395,000 402,600 1,426,946 1,567,330 1,638,096
Net cash used in investing activities                 20,208 (1,207,593) (797,381)
Net sales $ 681,200 $ 632,100 $ 681,100 $ 676,800 $ 730,300 $ 680,800 $ 691,100 $ 700,100 2,671,262 2,802,249 2,922,545
Net cash provided by operating activities                 $ 374,943 $ 194,447 $ 669,464