Supplemental Cash Flow Information (Tables)

9 Months Ended

Sep. 30, 2024

The reconciliation of net loss to net cash provided by operating activities is as follows (in millions):


	Nine Months Ended
	September 30,
	2024		2023
Net loss	$	(1,128.4)	$	(987.0)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	112.4		108.7
Reduction in the carrying amount of right-of-use assets	31.1		30.7
Share-based compensation	45.9		45.1
Acquired in-process research and development	29.5		—

Losses from change in fair market value of equity securities and loan receivable	1,680.3		1,576.5

Changes in fair value of contingent consideration	0.8		(18.5)
Payments for operating lease liabilities	(32.2)		(30.4)
Decrease in accounts receivable	25.6		31.6
Increase in inventories	(16.0)		(61.7)
(Increase) decrease in other current assets	(4.7)		15.0
Decrease in accounts payable and other current liabilities	(24.4)		(72.4)
Increase in income taxes payable	21.8		56.4
Decrease in deferred income taxes	(408.5)		(397.4)
Increase in other long-term liabilities	1.4		3.9
Other	(3.6)		(6.6)
Net cash provided by operating activities	$	331.0	$	293.9

Non-cash investing activities:
Purchased property, plant and equipment	$	7.4	$	2.9
Purchased marketable securities and investments	$	5.7	$	—
Sold marketable securities and investments	$	0.2	$	—