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Supplemental Cash Flow Information (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 30, 2023
Jun. 30, 2023
Mar. 31, 2023
Sep. 30, 2024
Sep. 30, 2023
Supplemental Cash Flow Elements [Abstract]                
Net loss $ 653,172 $ (2,165,486) $ 383,916 $ 106,257 $ (1,162,251) $ 68,962 $ (1,128,398) $ (987,032)
Depreciation and amortization             112,400 108,700
Reduction in the carrying amount of right-of-use assets             31,100 30,700
Share-based Compensation             45,900 45,100
Acquired in-process research and development             29,500 0
(Gains) losses from change in fair market value of equity securities and loan receivable             1,680,300 1,576,500
Changes in fair value of contingent consideration             800 (18,500)
Payments of operating lease liabilities             (32,200) (30,400)
Decrease in accounts receivable             25,600 31,600
Decrease (increase) in inventories             (16,000) (61,700)
Increase in other current assets             (4,700) 15,000
Decrease in accounts payable and other current liabilities             (24,400) (72,400)
Increase in income taxes payable             21,800 56,400
Increase in deferred income taxes             (408,500) (397,400)
Increase in other long term liabilities             1,400 3,900
Other             (3,600) (6,600)
Net cash provided by operating activities             331,048 293,896
Noncash or Part Noncash Acquisition, Fixed Assets Acquired             7,400 2,900
Noncash or Part Noncash Acquisition, Investments Acquired             5,700 0
Sold marketable securities and investments             $ 200 $ 0