Supplemental Cash Flow Information

12 Months Ended

Dec. 31, 2024

12. SUPPLEMENTAL CASH FLOW INFORMATION

The reconciliation of net loss to net cash provided by operating activities is as follows (in millions):


	Year Ended December 31,
	2024		2023		2022
Net loss	$	(1,844.2)	$	(637.3)	$	(3,627.5)
Adjustments to reconcile net loss
to net cash provided by operating activities
Depreciation and amortization	151.6		145.9		137.3
Reduction in the carrying amount of right-of-use assets	41.2		46.5		39.9
Share-based compensation	62.3		61.3		60.9
Acquired in-process research and development	29.5		—		—

Other-than-temporary impairment losses on investments	—		—		11.9
Current expected credit losses on loans	—		—		7.5
Losses from change in fair market value of equity securities and loan receivable	2,656.8		1,252.3		5,193.6


Gain on divestiture of a division	—		(2.5)		(1.4)
Payments for operating lease liabilities	(42.8)		(41.0)		(38.1)
Changes in fair value of contingent consideration	12.5		(18.1)		—
(Increase) decrease in accounts receivable	16.2		11.4		(87.4)
(Increase) decrease in inventories	8.5		(46.3)		(158.8)
(Increase) decrease in other current assets	(2.2)		5.6		(27.3)
Decrease in accounts payable and other current liabilities	(40.9)		(51.8)		(94.2)
Increase (decrease) in income taxes payable	24.1		(21.3)		(1.2)
Decrease in deferred income taxes	(626.8)		(322.6)		(1,241.6)
Increase in other long-term assets	(5.3)		(3.7)		(5.1)
Increase (decrease) in other long-term liabilities	5.6		(4.1)		5.6

Other	9.1		0.6		20.3
Net cash provided by operating activities	$	455.2	$	374.9	$	194.4

Non-cash investing activities:
Purchased property, plant and equipment	$	4.2	$	6.9	$	7.3
Purchased marketable securities and investments	$	—	$	0.4	$	—