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Segment Information (Tables)

12 Months Ended

Dec. 31, 2024

Segment Reporting [Abstract]

Information regarding industry segments

Information regarding industry segments at December 31, 2024, 2023, and 2022 and for the years then ended is as follows (in millions):

									Life Science						Clinical Diagnostics						Other Operations
Net sales			2024						$	1,028.1					$	1,537.9					$	0.5
			2023						1,178.4						1,489.3						3.5
			2022						1,347.2						1,451.0						4.0
Cost of goods sold			2024						$	445.7					$	741.3					$	0.6
			2023						514.4						725.8						4.1
			2022						532.7						696.5						5.7
Depreciation and amortization			2024						$	67.3					$	84.3					$	—
			2023						62.8						83.1						—
			2022						57.9						79.4						—
Segment profit			2024						$	582.4					$	796.6					$	(0.1)
			2023						664.0						763.5						(0.6)
			2022						814.5						754.5						(1.7)
Segment assets			2024						$	286.7					$	473.3					$	—
			2023						287.1						493.1						0.3
			2022						269.9						448.8						0.6

Reconciliation of segment profit to consolidated income before taxes

The following reconciles total segment gross profit to consolidated income (loss) before income taxes (in millions):

			Year Ended December 31,
			2024						2023						2022
Total segment profit			$	1,378.9					$	1,426.9					$	1,567.3
Selling, general and administrative expense			(814.0)						(841.7)						(827.8)
Research and development expense			(295.9)						(247.4)						(256.9)
Interest expense			(48.9)						(49.4)						(38.1)
Foreign currency exchange gains, net			3.9						7.3						0.2
Losses from change in fair market value of equity securities and loan receivable			(2,656.8)						(1,252.3)						(5,193.6)
Other income, net			90.3						106.5						44.7
Consolidated income (loss) before income taxes			$	(2,342.5)					$	(850.1)					$	(4,704.2)

Reconciliation of Assets from Segment to Consolidated

The following reconciles total segment assets to consolidated total assets (in millions):

						December 31,
						2024						2023
Total segment assets						$	760.0					$	780.5
Cash, short-term investments and other current assets						2,270.3						2,267.8
Property, plant and equipment, net, and operating lease right-of-use assets						688.6						723.7
Goodwill, net						410.5						413.6
Other long-term assets						5,234.7						8,113.5
Total assets						$	9,364.1					$	12,299.1

Net sales and assets to external customers by geographic area

The following presents net sales to external customers by geographic region based primarily on the location of the use of the product or service (in millions):

						Year Ended December 31,
						2024						2023						2022
United States						$	1,041.5					$	1,121.9					$	1,155.5
Europe						834.1						819.8						851.9
Asia						521.6						563.0						639.4
Other (primarily Canada and Latin America)						169.3						166.5						155.4
Total net sales						$	2,566.5					$	2,671.2					$	2,802.2

The following presents Property, plant and equipment, net, Operating lease right-of-use assets and Other assets, excluding deferred income taxes, by geographic region based upon the location of the asset (in millions):

						December 31,
						2024						2023
United States						$	461.4					$	477.3
Europe						171.3						197.0
Asia						97.1						82.7
Other (primarily Canada and Latin America)						14.1						19.1
Total Property, plant and equipment, net, Operating lease right-of-use assets and Other assets, excluding deferred income taxes						$	743.9					$	776.1

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- Definition

Tabular disclosure of all significant reconciling items in the reconciliation of total assets from reportable segments to the entity's consolidated assets.

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Tabular disclosure of the reconciliation of profit (loss) from reportable segments to the consolidated income (loss) before income tax expense (benefit) and discontinued operations. Includes, but is not limited to, reconciliation after income tax if income tax is allocated to the reportable segment.

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Tabular disclosure of information concerning material long-lived assets (excluding financial instruments, customer relationships with financial institutions, mortgage and other servicing rights, deferred policy acquisition costs, and deferred taxes assets) located in identified geographic areas and/or the amount of revenue from external customers attributed to that country from which revenue is material. An entity may also provide subtotals of geographic information about groups of countries.

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Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

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