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Fair Value Measurements and Investments (Details)
€ in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2024
EUR (€)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Trading, and Equity Securities, FV-NI $ 317.5 [1] $ 325.7 [1]   € 400.0
Debt Securities, Available-for-sale [2] 1,097.6      
Equity Securities, FV-NI, Unrealized Loss $ (2,681.6)      
Derivative, Forward Interest Rate 1.50%     1.50%
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability $ 12.5 (18.1) $ 0.0  
Loss from change in fair market value of value appreciation rights (25.9)      
Fair Value, Recurring [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Restricted Investments, at Fair Value [3] 1.6 7.1    
Equity Securities, FV-NI [4] 4,548.0 7,399.3    
Debt Securities, Trading, and Equity Securities, FV-NI [1] 317.5 325.7    
Debt Securities, Available-for-sale 1,097.6 1,136.0    
Forward foreign exchange contracts, Asset [5] 8.8 4.1    
Financial Assets Carried at Fair Value 6,159.0 8,956.3    
Forward foreign exchange contracts, Liability [6] 2.4 11.7    
Business Combination, Contingent Consideration, Liability [7]   17.5    
Liabilities, Fair Value Disclosure 2.4 29.2    
Fair Value, Recurring [Member] | Research and Development Expense [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability 12.5 14.0    
Fair Value, Recurring [Member] | Selling, General and Administrative Expenses [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability   4.1    
Fair Value, Recurring [Member] | Asset-backed Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 430.8 323.7    
Fair Value, Recurring [Member] | Corporate Debt Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 533.6 531.6    
Fair Value, Recurring [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 118.6 255.9    
Fair Value, Recurring [Member] | Foreign Government Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 5.2 12.7    
Fair Value, Recurring [Member] | Municipal Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 9.4 12.1    
Fair Value, Recurring [Member] | Commercial Paper [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8]   12.5    
Fair Value, Recurring [Member] | Time Deposits [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 31.2 36.6    
Fair Value, Recurring [Member] | Money Market Funds [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 139.4 28.0    
Fair Value, Recurring [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 14.9 7.0    
Fair Value, Recurring [Member] | Cash Equivalents [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 185.5 84.1    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Restricted Investments, at Fair Value [3] 1.6 7.1    
Equity Securities, FV-NI [4] 4,548.0 7,399.3    
Debt Securities, Trading, and Equity Securities, FV-NI [1] 0.0 0.0    
Debt Securities, Available-for-sale 0.0 0.0    
Forward foreign exchange contracts, Asset [5] 0.0 0.0    
Financial Assets Carried at Fair Value 4,689.0 7,434.4    
Forward foreign exchange contracts, Liability [6] 0.0 0.0    
Business Combination, Contingent Consideration, Liability [7]   0.0    
Liabilities, Fair Value Disclosure 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Asset-backed Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Corporate Debt Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Foreign Government Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Municipal Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Commercial Paper [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8]   0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Time Deposits [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Money Market Funds [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 139.4 28.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Cash Equivalents [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 139.4 28.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Restricted Investments, at Fair Value [3] 0.0 0.0    
Equity Securities, FV-NI [4] 0.0 0.0    
Debt Securities, Trading, and Equity Securities, FV-NI [1] 0.0 0.0    
Debt Securities, Available-for-sale 1,097.6 1,136.0    
Forward foreign exchange contracts, Asset [5] 8.8 4.1    
Financial Assets Carried at Fair Value 1,152.5 1,196.2    
Forward foreign exchange contracts, Liability [6] 2.4 11.7    
Business Combination, Contingent Consideration, Liability [7]   0.0    
Liabilities, Fair Value Disclosure 2.4 11.7    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Asset-backed Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 430.8 323.7    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Corporate Debt Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 533.6 531.6    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 118.6 255.9    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Foreign Government Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 5.2 12.7    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Municipal Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 9.4 12.1    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Commercial Paper [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8]   12.5    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Time Deposits [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 31.2 36.6    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Money Market Funds [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 14.9 7.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Cash Equivalents [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 46.1 56.1    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Restricted Investments, at Fair Value [3] 0.0 0.0    
Equity Securities, FV-NI [4] 0.0 0.0    
Debt Securities, Trading, and Equity Securities, FV-NI [1] 317.5 325.7    
Debt Securities, Available-for-sale 0.0 0.0    
Forward foreign exchange contracts, Asset [5] 0.0 0.0    
Financial Assets Carried at Fair Value 317.5 325.7    
Forward foreign exchange contracts, Liability [6] 0.0 0.0    
Business Combination, Contingent Consideration, Liability [7]   17.5    
Liabilities, Fair Value Disclosure 0.0 17.5    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Asset-backed Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Corporate Debt Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Foreign Government Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Municipal Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Commercial Paper [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8]   0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Time Deposits [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Money Market Funds [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Cash Equivalents [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Cash equivalents [8] 0.0 0.0    
Short-term Investments [Member] | Fair Value, Recurring [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Equity Securities, FV-NI 78.8 67.2    
Short-term Investments [Member] | Fair Value, Recurring [Member] | Asset-backed Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 430.8 323.7    
Short-term Investments [Member] | Fair Value, Recurring [Member] | Corporate Debt Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 533.6 531.6    
Short-term Investments [Member] | Fair Value, Recurring [Member] | US Government Sponsored Agencies [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 118.6 255.9    
Short-term Investments [Member] | Fair Value, Recurring [Member] | Foreign Government Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 5.2 12.7    
Short-term Investments [Member] | Fair Value, Recurring [Member] | Municipal Obligations [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 9.4 12.1    
Short-term Investments [Member] | Fair Value, Recurring [Member] | Debt Securities [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Debt Securities, Available-for-sale [2] 1,097.6 1,136.0    
Other Investments [Member] | Fair Value, Recurring [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Restricted Investments, at Fair Value 1.6 1.5    
Equity Securities, FV-NI 4,469.2 7,332.1    
Restricted investment | Fair Value, Recurring [Member]        
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]        
Restricted Investments, at Fair Value $ 0.0 $ 5.6    
[1] The Loan under the fair value option is included in Other investments in the consolidated balance sheets.
[2] Available-for-sale investments are included in Short-term investments in the consolidated balance sheets.
[3] Restricted investments are included in the following accounts in the consolidated balance sheets (in millions):
December 31, 2024December 31, 2023
Restricted investments$— $5.6 
Other investments1.61.5 
   Total$1.6 $7.1 
[4] Equity securities are included in the following accounts in the consolidated balance sheets (in millions):
December 31, 2024December 31, 2023
Short-term investments$78.8 $67.2 
Other investments4,469.2 7,332.1 
   Total$4,548.0 $7,399.3 
[5] Forward foreign exchange contracts in an asset position are included in Other current assets in the consolidated balance sheets.
[6] Forward foreign exchange contracts in a liability position are included in Other current liabilities in the consolidated balance sheets.
[7] Contingent considerations in a liability position are included in Other long-term liabilities in the consolidated balance sheets. The changes in the fair value of contingent consideration included in Research and development expense and Selling, general and administrative expense amounted to $14.0 million and $4.1 million, respectively, in the consolidated statements of income (loss) for the year ended December 31, 2023. During the year ended December 31, 2024, the settlement of the contingent liability resulted in Research and development expense of $12.5 million in the consolidated statements of income (loss).
[8] Cash equivalents are included in Cash and cash equivalents in the consolidated balance sheets.