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Stock options and warrants (Tables)

3 Months Ended

Mar. 31, 2013

Stock Options [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Share Based Compensation Employees and Consultants

		2013				2012
Stock options to employees and directors		$	483,625			$	197,402
Stock options to consultants for:
Investor relations activities			-				20,227
APPY1 activities			597				1,491
Animal health activities			-				2,876
Total stock-based compensation		$	484,222			$	221,996

Schedule of Stock Based Compensation Expenses

		Three Months Ended
		2013				2012
Selling, general and administrative expenses		$	483,625			$	220,505
Research and development expenses			597				1,491
Total stock-based compensation		$	484,222			$	221,996

Stock Incentive Plan Options [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Assumptions Used in the Estimation of Fair Value of Stock Based Compensation

			2013
Dividend yield				0%
Expected price volatility				127-128%
Risk free interest rate				0.72-0.76 %
Expected term			5 years

Schedule of Share-based Compensation, Employee Incentive Plan, Activity

		Shares Underlying Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (Years)				Aggregate Intrinsic Value
Outstanding at January 1, 2013			707,940			$	13.98
Granted			474,270				2.09
Exercised			-				-
Forfeited			(6,644	)			2.43
Outstanding at March 31, 2013			1,175,566			$	9.25				9.05			$	85,200
Exercisable at March 31, 2013			261,506			$	33.15				6.72			$	10,400

Schedule of Nonvested Share Activity

Nonvested Shares		Nonvested Shares Underlying Options				Weighted Average Exercise Price				Weighted Average Grant Date Fair Value
Nonvested at January 1, 2013			508,435			$	3.70			$	3.07
Granted			474,270				2.09				1.78
Vested			(62,001	)			10.55				8.58
Forfeited			(6,644	)			2.43				2.04
Nonvested at March 31, 2013			914,060			$	2.41			$	2.03

Other Options and Warrants [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Nonvested Share Activity

Nonvested Shares		Nonvested Shares Underlying Options				Weighted Average Exercise Price				Weighted Average Grant Date Fair Value
Nonvested at January 1, 2013			8,332			$	3.42			$	2.84
Granted			-				-				-
Vested			(5,000	)			3.42				2.84
Forfeited			-				-				-
Nonvested at March 31, 2013			3,332			$	3.42			$	2.84

Summary of Stock Option Activity Under Stock Option and Incentive Plans

		Shares Underlying Options / Warrants				Weighted Average Exercise Price			Weighted Average Remaining Contractual Term (Years)			Aggregate Intrinsic Value
Outstanding at January 1, 2013			598,507			$	5.01
Granted			-				-
Exercised			-				-
Forfeited			(501	)			54.00
Outstanding at March 31, 2013			598,006			$	4.97		4.37		$	-
Exercisable at March 31, 2013			289,673			$	7.59		4.47		$	-

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