<SEC-DOCUMENT>0000950103-21-008071.txt : 20210528
<SEC-HEADER>0000950103-21-008071.hdr.sgml : 20210528
<ACCEPTANCE-DATETIME>20210528060542
ACCESSION NUMBER:		0000950103-21-008071
CONFORMED SUBMISSION TYPE:	SD
PUBLIC DOCUMENT COUNT:		1
<RULE>
<RULE-NAME>13p-1
<ITEM>
<ITEM-NUMBER>1.01
<ITEM-PERIOD>20201231
</ITEM>
</RULE>
FILED AS OF DATE:		20210528
DATE AS OF CHANGE:		20210528

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
		CENTRAL INDEX KEY:			0001100682
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				061397316
		FISCAL YEAR END:			1226

	FILING VALUES:
		FORM TYPE:		SD
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15943
		FILM NUMBER:		21975900

	BUSINESS ADDRESS:	
		STREET 1:		251 BALLARDVALE ST
		CITY:			WILMINGTON
		STATE:			MA
		ZIP:			01887
		BUSINESS PHONE:		781-222-6000

	MAIL ADDRESS:	
		STREET 1:		251 BALLARDVALE ST
		CITY:			WILMINGTON
		STATE:			MA
		ZIP:			01887

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHARLES RIVER LABORATORIES INTERNATIONAL INC
		DATE OF NAME CHANGE:	20000605

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHARLES RIVER LABORATORIES HOLDINGS INC
		DATE OF NAME CHANGE:	19991208
</SEC-HEADER>
<DOCUMENT>
<TYPE>SD
<SEQUENCE>1
<FILENAME>dp151959_sd.htm
<DESCRIPTION>FORM SD
<TEXT>
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     <TITLE></TITLE>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 82%; border-right: Black 1pt solid; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="width: 18%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 12pt"><FONT STYLE="font-size: 10pt">OMB APPROVAL</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">OMB Number: 3235-0697</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 23.95pt 0pt 0">Expires: March 31, 2023 Estimated average burden hours
    per response.480.61</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 23.95pt 0pt 0"></P></TD></TR>
  </TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">UNITED STATES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.6pt; text-align: center"><B>FORM SD</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.6pt; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"><B>Specialized Disclosure Report</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"><B>Charles River Laboratories
International, Inc.</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center">(Exact name of registrant as
specified in its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; width: 33%; font-weight: bold">State of Delaware</TD>
    <TD STYLE="text-align: center; width: 33%; font-weight: bold">001-15943</TD>
    <TD STYLE="text-align: center; width: 33%; font-weight: bold">06-1397316</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(State or other jurisdiction</TD>
    <TD STYLE="text-align: center">(Commission</TD>
    <TD STYLE="text-align: center">(IRS Employer</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">of incorporation or organization)</TD>
    <TD STYLE="text-align: center">File Number)</TD>
    <TD STYLE="text-align: center">Identification No.)</TD></TR>
  </TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; width: 50%; font-weight: bold">251 Ballardvale Street</TD>
    <TD STYLE="text-align: center; width: 50%; font-weight: bold">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; font-size: 11pt"><FONT STYLE="font-size: 10pt"><B>Wilmington, Massachusetts</B></FONT></TD>
    <TD STYLE="text-align: center; font-size: 11pt"><FONT STYLE="font-size: 10pt"><B>01887</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">(Address of principal executive offices)</TD>
    <TD STYLE="text-align: center">(Zip Code)</TD></TR>
  </TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.55pt; text-align: center">Matthew Daniel, (781) 222-6000</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.55pt; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">(Name and telephone number, including
area code, of the person to contact in connection with this report.)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Check the appropriate box to indicate the rule pursuant to
which this form is being filed, and provide the period to which the information in this form applies:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.05pt"></TD><TD STYLE="width: 35.9pt">&#9746;</TD><TD STYLE="padding-right: 8.65pt">Rule 13p-1 under the Securities Exchange Act (17 CFR 240.13p-1) for the reporting period from January
1 to December 31, 2020.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Introduction</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">Charles River Laboratories International, Inc. (Charles
River, we, us) is a full service, early-stage contract research organization. We have built upon our core competency of laboratory animal
medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and
non-GLP, which is able to support our clients from target identification through non-clinical development. We also provide a suite of
products and services to support our client&rsquo;s manufacturing activities. Utilizing our broad portfolio of products and services enables
our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness,
and increases speed to market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">Charles River is aware of the grave concerns and global
issues that stem from the commercialization of <I>Conflict Minerals </I>in the Democratic Republic of the Congo and its adjoining countries.
Thus, Charles River has been actively working with its business partners and others to promote responsible sourcing of <I>Conflict Minerals
</I>within its supply chain.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.4pt 0pt 15pt">In accordance with Rule 13p-1 (17 CFR 240.13p-1) under
the Securities Exchange Act of 1934, as amended, and Form SD (collectively, the Rule), Charles River has conducted a Reasonable Country
of Origin Inquiry (RCOI) and related due diligence consistent with the Organization for Economic Co-operation and Development (OECD) Due
Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High Risk Areas, and the OECD Supplement on Tin,
Tantalum, and Tungsten (Second Edition, 2013) for its Endosafe Products (described below).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.4pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">For purposes hereof, all <I>capitalized and italicized
</I>terms used herein and not otherwise defined shall have the meaning ascribed to such terms in the Rule.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Forward - Looking Statements</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">This disclosure may contain forward-looking statements within
the meaning of the federal securities laws. Any statements that do not relate to historical or current facts or matters are forward-looking
statements. You can identify some forward-looking statements using forward-looking words, such as &ldquo;intend&rdquo; or the use of the
future tense.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">Statements concerning current conditions may also be
forward-looking if they imply a continuation of current conditions. Examples of forward-looking statements include, but are not limited
to, statements concerning the steps we intend to take to mitigate the risk that our necessary <I>Conflict Minerals </I>may benefit armed
groups.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.75pt 0pt 15pt">Forward-looking statements are subject to risks and uncertainties
that could cause actual actions or performance to differ materially from those expressed in the forward-looking statements. These risks
and uncertainties include, but are not limited to: (i) the implementation of satisfactory traceability and other compliance measures by
our direct and indirect suppliers, on a timely basis or at all; (ii) whether smelters and refiners and other market participants responsibly
source <I>Conflict Minerals</I>, and (iii) political and regulatory developments, whether in the <I>Covered Countries</I>, the United
States or elsewhere. You are cautioned not to place undue reliance on such forward-looking statements, which (if any) apply only as of
the date of the filing of this disclosure. We do not intend, and undertake no obligation, to publish revised forward-looking statements
to reflect events or circumstances after the date of filing this disclosure or to reflect the occurrence of unanticipated events.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.75pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Product Overview</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Charles River does not knowingly or intentionally procure
or otherwise source <I>Conflict Minerals </I>for any of its products that it manufactures or contracts to manufacture, except with regards
to its Endosafe Products.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 15pt">Charles River&rsquo;s Microbial Solutions division provides
clients with <I>in vitro </I>methods for conventional and rapid quality control testing of sterile and non-sterile biopharmaceutical and
consumer products. In connection therewith, the Microbial Solutions division contracts to manufacture for sale to third parties three
(3) products (the Endosafe&reg;- PTS Portable Test System; Endosafe&reg;-nexgen PTS Portable Test System; and Endosafe&reg;-MCS Multi-Cartridge
System; collectively the Endosafe Products) that contain electronic components, some of which include certain <I>Conflict Minerals </I>(tantalum
and tin) that are necessary for their functionality and/or production.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 15pt">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 15pt">The Endosafe Products form a rapid, point-of-use test
system comprised of test cartridges and use of a spectrophotometer where certain assays can be executed (<I>e.g</I>., Gram ID, Inhibition/Enhancement
LAL, Glucan) and can determine if certain injectable therapeutics during the drug manufacturing and production processes are safe for
human use (<I>i.e</I>., whether such therapeutics are endotoxin-free). Tantalum is used in certain capacitors within the power circuitry
as it dramatically reduces the size of the capacitor and eliminates chemical disposal issues; and tin is used to solder electronics components
on printed circuit boards consistent with industry practice due to its reliable performance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">SECTION 1 - CONFLICT MINERALS DISCLOSURE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 209.3pt 0pt 15pt"><B>Item 1.01 Conflict Minerals Disclosure and Report
Reasonable Country of Origin Inquiry Efforts</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 209.3pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 15pt">Charles River conducted, in good faith, a RCOI in accordance
with the Rule, followed by related due diligence in regards to its Endosafe Products and the <I>Conflict Minerals </I>utilized therein,
which are necessary for their functionality and/or production. Our supply chain with respect to Endosafe Products is complex, as we purchase
parts and materials directly, or contract with others to manufacture parts, from many suppliers; however, we do not purchase any <I>Conflict
Minerals </I>directly from any smelters, mines or refiners. In most cases, there are multiple layers of third parties between Charles
River and the ultimate upstream source of the <I>Conflict Minerals</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">We engaged Assent Compliance Inc. (Assent) to help us obtain
information, representations and certifications concerning the presence of <I>Conflict Minerals </I>in our Endosafe Products (if any),
and the sourcing thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 6.15pt 0pt 15pt">Specifically, we identified 110 suppliers who provide
Endosafe Product components which may contain <I>Conflict Minerals</I>. With the help of Assent, we developed and executed a communication
and inquiry program whereby each identified supplier was contacted a minimum of four times <I>via </I>phone-calls and email communications
and asked to complete a Responsible Sourcing Initiative (RMI) Conflict Minerals Reporting Template (CMRT). The CMRTs and material correspondence
from our suppliers were documented and aggregated into Assent&rsquo;s survey platform, which can (among other functions) validate whether
smelters and refineries used by suppliers are recognized as compliant with the RMI (formerly the Conflict Free Sourcing Initiative) protocol,
and provide a risk assessment of the suppliers used. The following outputs were reported:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 6.15pt 0pt 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 33.05pt"></TD><TD STYLE="width: 17.9pt">&bull;</TD><TD STYLE="padding-right: 17.3pt">Response Rate: 99%, which represents the percentage of identified suppliers who responded to our inquiries
regarding the presence of <I>Conflict Minerals</I> in our Endosafe Products, and the sourcing thereof.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 33.05pt"></TD><TD STYLE="width: 17.9pt">&bull;</TD><TD>The responding suppliers account for 99% of the components used in the Endosafe Products.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 33.05pt"></TD><TD STYLE="width: 17.9pt">&bull;</TD><TD>Of responding suppliers:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 67.5pt"></TD><TD STYLE="width: 18pt">&#9702;</TD><TD>25 suppliers reported no <I>Conflict Minerals </I>are present in their components sold to Charles River;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 67.5pt"></TD><TD STYLE="width: 18pt">&#9702;</TD><TD STYLE="padding-right: 8.8pt">16 suppliers reported <I>Conflict Minerals</I> are present in their components sold to Charles River,
and such <I>Conflict Minerals </I>are not sourced from any <I>Covered Country</I> ;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 69.05pt"></TD><TD STYLE="width: 17.9pt">&#9702;</TD><TD STYLE="padding-right: 6.25pt">19 suppliers reported <I>Conflict Minerals </I>are present in their components sold to Charles River,
and such <I>Conflict Minerals </I>are sourced from a <I>Covered Country</I>, but such suppliers could otherwise represent they are not
supporting armed groups since they buy <I>Conflict Minerals </I>exclusively from smelters and refiners that are CFSI compliant;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 69pt"></TD><TD STYLE="width: 18pt">&#9702;</TD><TD STYLE="text-align: justify; padding-right: 7.7pt">9 suppliers reported <I>Conflict Minerals </I>are present in their components sold
to Charles River, and such <I>Conflict Minerals</I> are sourced from a <I>Covered Country</I>, but sourced from smelters or refiners not
compliant with CFSI; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 69pt"></TD><TD STYLE="width: 18pt">&#9702;</TD><TD STYLE="text-align: justify">41 suppliers could not provide sufficient detail as to whether they sourced from a <I>Covered Country</I></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 87pt; text-align: justify">and/or whether smelters or refiners in
their supply chain were CFSI compliant.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 87pt; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.7pt 0pt 15pt"><I>Note: Suppliers sourcing more than one Conflict Mineral
for components sold to Charles River may have responded differently with regards to each Conflict Mineral sourced, and therefore any such
supplier may have been allocated to more than one output above.</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2.7pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.85pt 0pt 15pt">We are encouraged by the consistent engagement with our
suppliers (45% suppliers representing responsible sourcing of <I>Conflict Minerals</I>, as compared with 58% and 62% in the 2019 and 2018
reporting years, respectively). We credit this level of engagement to our internal and cross-functional Conflict Minerals Team (with members
from</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.85pt 0pt 15pt">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">Compliance, Legal, Procurement and Operations), which,
with the help of Assent, actively engages with our suppliers and employees to explore solutions in sourcing <I>Conflict Minerals </I>responsibly,
and raise awareness in our supply chain and among our employees of the issues and concerns surrounding <I>Conflict Minerals</I>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">We have maintained our Statement on Conflict Minerals
Law Compliance (available at <FONT STYLE="color: blue"><U>http://ir.criver.com/ phoenix.zhtml?c=121668&amp;p=irol-Compliance</U></FONT>
) which outlines our commitment to sourcing <I>Conflict Minerals </I>responsibly, and our Compliance &amp; Ethics Hotline (available at
1-866-294-3699, or <FONT STYLE="color: blue"><U>http://helpline.criver.com</U></FONT>); and we have provided our suppliers and employees
with access to Assent&rsquo;s Conflict Mineral Resource Centers where tutorials, further education, and other resources can be found regarding
<I>Conflict Minerals </I>and compliance related laws and regulations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Conclusion based on Reasonable Country of Origin Inquiry</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">Despite our efforts to date, including our RCOI and related
diligence, and in consideration of the complexity of our supply chain and the Endosafe Products themselves, we could not determine that
our supply chain was not sourcing <I>Conflict Minerals </I>from one or more of the <I>Covered Countries</I>. While we believe a 99% response
rate from our suppliers is significant, we understand further improvements to our evaluation efforts and diligence practices, as well
as increased representations from our suppliers that <I>Conflict Minerals </I>are sourced responsibly, are needed to maintain and advance
this level of engagement with our suppliers and ultimately improve upon the areas where suppliers stated the source of the <I>Conflict
Minerals </I>was either unknown or known to be non-conformant. These improvements over time will lead to a supply chain that is <I>DRC
Conflict Mineral Free</I>; and therefore, we will continue to work with our partners, suppliers and supplier candidates to further develop
our evaluation efforts and diligence practices.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">Conflicts Mineral Disclosure</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">This information is publicly available at <FONT STYLE="color: blue"><U>www.criver.com</U></FONT>
at the SEC filings link on the investor relations page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt">&nbsp;</P>


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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>SIGNATURES</B></FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in">Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the duly authorized undersigned.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in">CHARLES
RIVER LABORATORIES INTERNATIONAL, INC<FONT STYLE="font-weight: normal">.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; width: 6%">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 28%"><FONT STYLE="font-size: 10pt">/s/ Matthew Daniel</FONT></TD>
    <TD STYLE="width: 66%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>Name: &nbsp;&nbsp;</TD>
    <TD>Matthew Daniel</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>Title:</TD>
    <TD>Senior Vice President, General Counsel, Corporate Secretary and Chief Compliance Officer</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>Date:</TD>
    <TD>May 28<SUP>th</SUP>, 2021</TD>
    <TD>&nbsp;</TD></TR>
  </TABLE>
<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">Form SD</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt"></P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">(Specialized Disclosure
Report)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 172.1pt 0pt 185.2pt; text-indent: 45.3pt">&nbsp;</P>

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