<SEC-DOCUMENT>0000950103-22-009347.txt : 20220526
<SEC-HEADER>0000950103-22-009347.hdr.sgml : 20220526
<ACCEPTANCE-DATETIME>20220526161615
ACCESSION NUMBER:		0000950103-22-009347
CONFORMED SUBMISSION TYPE:	SD
PUBLIC DOCUMENT COUNT:		1
<RULE>
<RULE-NAME>13p-1
<ITEM>
<ITEM-NUMBER>1.01
<ITEM-PERIOD>20211231
</ITEM>
</RULE>
FILED AS OF DATE:		20220526
DATE AS OF CHANGE:		20220526

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
		CENTRAL INDEX KEY:			0001100682
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				061397316
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SD
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15943
		FILM NUMBER:		22970220

	BUSINESS ADDRESS:	
		STREET 1:		251 BALLARDVALE ST
		CITY:			WILMINGTON
		STATE:			MA
		ZIP:			01887
		BUSINESS PHONE:		781-222-6000

	MAIL ADDRESS:	
		STREET 1:		251 BALLARDVALE ST
		CITY:			WILMINGTON
		STATE:			MA
		ZIP:			01887

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHARLES RIVER LABORATORIES INTERNATIONAL INC
		DATE OF NAME CHANGE:	20000605

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHARLES RIVER LABORATORIES HOLDINGS INC
		DATE OF NAME CHANGE:	19991208
</SEC-HEADER>
<DOCUMENT>
<TYPE>SD
<SEQUENCE>1
<FILENAME>dp173953_sd.htm
<DESCRIPTION>FORM SD
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="width: 39%">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; border: black 1.5pt solid; text-align: left; width: 28%"><FONT STYLE="font-size: 10pt">OMB APPROVAL</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; border-left: black 1.5pt solid; border-right: black 1.5pt solid"><FONT STYLE="font-size: 10pt">OMB Number: 3235-0697</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; border-right: black 1.5pt solid; border-left: black 1.5pt solid; text-align: left"><FONT STYLE="font-size: 10pt">Expires: July 31, 2024</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; border-right: black 1.5pt solid; border-left: black 1.5pt solid; text-align: left"><FONT STYLE="font-size: 10pt">Estimated average burden</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; border-right: black 1.5pt solid; border-left: black 1.5pt solid; text-align: left"><FONT STYLE="font-size: 10pt">hours per response...477.89</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid">&nbsp;</TD></TR>
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<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">UNITED STATES</P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.6pt; text-align: center"><B>FORM SD</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.6pt; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"><B>Specialized Disclosure Report</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"><B>Charles River Laboratories
International, Inc.</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center">(Exact name of registrant as
specified in its charter)</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; width: 33%; font-weight: bold"><FONT STYLE="font-size: 10pt">State of Delaware</FONT></TD>
    <TD STYLE="text-align: center; width: 34%; font-weight: bold"><FONT STYLE="font-size: 10pt">001-15943</FONT></TD>
    <TD STYLE="text-align: center; width: 33%; font-weight: bold"><FONT STYLE="font-size: 10pt">06-1397316</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(State or other jurisdiction</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Commission</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(IRS Employer</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">of incorporation or organization)</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">File Number)</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">Identification No.)</FONT></TD></TR>
  </TABLE>
<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 107.05pt"></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 107.05pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; width: 50%; font-weight: bold"><FONT STYLE="font-size: 10pt">251 Ballardvale Street</FONT></TD>
    <TD STYLE="text-align: center; width: 50%; font-weight: bold"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; font-size: 11pt"><FONT STYLE="font-size: 10pt"><B>Wilmington, Massachusetts</B></FONT></TD>
    <TD STYLE="text-align: center; font-size: 11pt"><FONT STYLE="font-size: 10pt"><B>01887</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Address of principal executive offices)</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">(Zip Code)</FONT></TD></TR>
  </TABLE>
<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.55pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 29.55pt; text-align: center"><FONT STYLE="font-size: 10pt">Matthew
Daniel, (781) 222-6000</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"><FONT STYLE="font-size: 10pt">(Name
and telephone number, including area code, of the person to contact in connection with this report.)</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.6pt 0pt 34.55pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt"><FONT STYLE="font-size: 10pt">Check the appropriate box to
indicate the rule pursuant to which this form is being filed, and provide the period to which the information in this form applies:</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.05pt"></TD><TD STYLE="width: 35.9pt"><FONT STYLE="font-size: 10pt">&#9746;</FONT></TD><TD STYLE="padding-right: 8.65pt"><FONT STYLE="font-size: 10pt">Rule
                                            13p-1 under the Securities Exchange Act (17 CFR 240.13p-1) for the reporting period from
                                            January 1 to December 31, 2021.</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 11pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.05pt"></TD><TD STYLE="width: 35.9pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9744;</FONT></TD><TD STYLE="padding-right: 8.65pt"><FONT STYLE="font-size: 10pt">Rule
                                            13q-1 under the Securities Exchange Act (17 CFR 240.13q-1) for the fiscal year ended December
                                            25, 2021.</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 11pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>


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<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Introduction</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">Charles River Laboratories
International, Inc. (Charles River, we, us) <FONT STYLE="background-color: white">is a full service, non-clinical contract research organization
(CRO). We have built upon our original core competency of laboratory animal medicine and science (research model technologies) to develop
a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, which is able to support
our clients from target identification through non-clinical development. We also provide a suite of products and services to support
our clients&rsquo; manufacturing activities, including our newly acquired contract development and manufacturing organization (CDMO)
business. Utilizing our broad portfolio of products and services enables our clients to create a more flexible drug development model,
which reduces their costs, enhances their productivity and effectiveness, and increases speed to market.</FONT></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">Charles River is aware of
the grave concerns and global issues that stem from the commercialization of <I>Conflict Minerals </I>in the Democratic Republic of the
Congo and its adjoining countries. Thus, Charles River has been actively working with its business partners and others to promote responsible
sourcing of <I>Conflict Minerals </I>within its supply chain.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 5.4pt 0pt 0"><FONT STYLE="font-size: 10pt">In accordance with Rule 13p-1
(17 CFR 240.13p-1) under the Securities Exchange Act of 1934, as amended, and Form SD (collectively, the Rule), Charles River has conducted
a Reasonable Country of Origin Inquiry (RCOI) and related due diligence consistent with the Organization for Economic Co-operation and
Development (OECD) Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High Risk Areas, and the
OECD Supplement on Tin, Tantalum, and Tungsten (Second Edition, 2013) for its Endosafe Products (described below).</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 5.4pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">For purposes hereof, all
<I>capitalized and italicized </I>terms used herein and not otherwise defined shall have the meaning ascribed to such terms in the Rule.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Caution Concerning Forward - Looking
Statements</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">This Current Report on Form 8-K includes
forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may
be identified by the use of words such as &ldquo;anticipate,&rdquo; &ldquo;believe,&rdquo; &ldquo;expect,&rdquo; &ldquo;will,&rdquo;
&ldquo;would,&rdquo; &ldquo;may,&rdquo; &ldquo;estimate,&rdquo; &ldquo;plan,&rdquo; &ldquo;outlook,&rdquo; and &ldquo;project,&rdquo;
and other similar expressions that predict or indicate future events or trends or that are not statements of historical matters. Forward-looking
statements are based on the Company's current expectations and beliefs, and involve a number of risks and uncertainties that are difficult
to predict and that could cause actual results to differ materially from those stated or implied by the forward-looking statements. F<FONT STYLE="background-color: white">or
example, we may use forward-looking statements when addressing topics such as: </FONT>the steps we intend to take to mitigate the risk
that our necessary <I>Conflict Minerals </I>may benefit armed groups; the implementation of satisfactory traceability and other compliance
measures by our direct and indirect suppliers, on a timely basis or at all; whether smelters and refiners and other market participants
responsibly source <I>Conflict Minerals</I>, and political and regulatory developments, whether in the <I>Covered Countries</I>, the
United States or elsewhere. A further description of these risks, uncertainties, and other matters can be found in the Risk Factors detailed
in the Company's Annual Report on Form 10-K as filed on February 16, 2022, as well as other filings the Company makes with the Securities
and Exchange Commission. Because forward-looking statements involve risks and uncertainties, actual results and events may differ materially
from results and events currently expected by the Company, and the Company assumes no obligation and expressly disclaims any duty to
update information contained in this news release except as required by law</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Product Overview</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Charles River does not knowingly or
intentionally procure or otherwise source <I>Conflict Minerals </I>for any</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>


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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">of its products that it manufactures
or contracts to manufacture, except with regards to its Endosafe Products.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 0"><FONT STYLE="font-size: 10pt">Charles River&rsquo;s Microbial
Solutions business provides <I>in vitro </I>methods for conventional and rapid quality control testing. In connection therewith, the
Microbial Solutions division contracts to manufacture for sale to third parties three (3) products (the Endosafe&reg;- PTS Portable Test
System; Endosafe&reg;-nexgen PTS Portable Test System; and Endosafe&reg;-MCS Multi-Cartridge System; collectively the Endosafe Products)
that contain electronic components, some of which include certain <I>Conflict Minerals </I>(tantalum and tin) that are necessary for
their functionality and/or production.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 0"><FONT STYLE="font-size: 10pt">The Endosafe Products form
a rapid, point-of-use test system comprised of test cartridges and use of a spectrophotometer where certain assays can be executed (<I>e.g</I>.,
Gram ID, Inhibition/Enhancement LAL, Glucan) and can determine if certain injectable therapeutics during the drug manufacturing and production
processes are safe for human use (<I>i.e</I>., whether such therapeutics are endotoxin-free). Tantalum is used in certain capacitors
within the power circuitry as it dramatically reduces the size of the capacitor and eliminates chemical disposal issues; and tin is used
to solder electronics components on printed circuit boards consistent with industry practice due to its reliable performance.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">SECTION 1 - CONFLICT MINERALS DISCLOSURE</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Item 1.01 Conflict Minerals Disclosure
and Report Reasonable Country of Origin Inquiry Efforts</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 0"><FONT STYLE="font-size: 10pt">Charles River conducted, in
good faith, a RCOI in accordance with the Rule, followed by related and reasonable due diligence in regards to its Endosafe Products
and the <I>Conflict Minerals </I>utilized therein, which are necessary for their functionality and/or production. Our supply chain with
respect to Endosafe Products is complex, as we purchase parts and materials directly, or contract with others to manufacture parts, from
many suppliers; however, we do not purchase any <I>Conflict Minerals </I>directly from any smelters, mines or refiners. In most cases,
there are multiple layers of third parties between Charles River and the ultimate upstream source of the <I>Conflict Minerals</I>.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 4.9pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">We engaged Assent Compliance Inc. (Assent)
to help us obtain information, representations and certifications concerning the presence of <I>Conflict Minerals </I>in our Endosafe
Products (if any), and the sourcing thereof.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 6.15pt 0pt 0"><FONT STYLE="font-size: 10pt">Specifically, we identified
124 suppliers who provide Endosafe Product components which may contain <I>Conflict Minerals</I>. With the help of Assent, we developed
and executed a communication and inquiry program whereby each identified supplier was contacted a minimum of four times <I>via </I>phone-calls
and email communications and asked to complete a Responsible Sourcing Initiative (RMI) Conflict Minerals Reporting Template (CMRT). The
CMRTs and material correspondence from our suppliers were documented and aggregated into Assent&rsquo;s survey platform, which can (among
other functions) validate whether smelters and refineries used by suppliers are recognized as compliant with the RMI (formerly the Conflict
Free Sourcing Initiative) protocol, and provide a risk assessment of the suppliers used. The following outputs were reported:</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 6.15pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD><TD STYLE="padding-right: 17.3pt"><FONT STYLE="font-size: 10pt">Response
                                            Rate: 98%, which represents the percentage of identified suppliers who responded to our inquiries
                                            regarding the presence of <I>Conflict Minerals</I> in our Endosafe Products, and the sourcing
                                            thereof.</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 11pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD><TD STYLE="padding-right: 17.3pt"><FONT STYLE="font-size: 10pt">The
                                            responding suppliers account for 99% of the components used in the Endosafe Products.</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 11pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD><TD STYLE="padding-right: 17.3pt"><FONT STYLE="font-size: 10pt">Of
                                            responding suppliers:</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 11pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

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                                            suppliers reported no <I>Conflict Minerals </I>are present in their components sold to Charles
                                            River;</FONT></TD></TR></TABLE>

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                                            suppliers reported <I>Conflict Minerals</I> are present in their components sold to Charles
                                            River, and such <I>Conflict Minerals </I>are not sourced from any <I>Covered Country</I>
                                            ;</FONT></TD></TR></TABLE>

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                                            suppliers reported <I>Conflict Minerals </I>are present in their components sold to Charles
                                            River, and such <I>Conflict Minerals </I>are sourced from a <I>Covered Country</I>, but such
                                            suppliers could otherwise represent they are not supporting armed groups since they buy <I>Conflict
                                            Minerals </I>exclusively from smelters and refiners that are CFSI compliant;</FONT></TD></TR></TABLE>

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                                            suppliers reported <I>Conflict Minerals </I>are present in their components sold to Charles
                                            River, and such <I>Conflict Minerals</I> are sourced from a <I>Covered Country</I>, but sourced
                                            from smelters or refiners not compliant with CFSI; and</FONT></TD></TR></TABLE>

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                                            suppliers could not provide sufficient detail as to whether they sourced from a <I>Covered
                                            Country </I>and/or whether smelters or refiners in their supply chain were CFSI compliant.</FONT></TD></TR></TABLE>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 2.7pt 0pt 0"><FONT STYLE="font-size: 10pt"><I>Note: Suppliers sourcing
more than one Conflict Mineral for components sold to Charles River may have responded differently with regards to each Conflict Mineral
sourced, and therefore any such supplier may have been allocated to more than one output above.</I></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 2.7pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0.85pt 0pt 0"><FONT STYLE="font-size: 10pt">We are encouraged by the
consistent engagement with our suppliers (62% suppliers representing responsible sourcing of <I>Conflict Minerals</I>, as compared with
55% and 58% in the 2020 and 2019 reporting years, respectively). We credit this level of engagement to our internal and cross-functional
Conflict Minerals Team (with members from Compliance, Legal, Procurement and Operations), which, with the help of Assent, actively engages
with our suppliers and employees to explore solutions in sourcing <I>Conflict Minerals </I>responsibly, and raise awareness in our supply
chain and among our employees of the issues and concerns surrounding <I>Conflict Minerals</I>.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0.85pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">We have maintained our Statement
on Conflict Minerals Law Compliance (available at <FONT STYLE="color: blue"><U>https://ir.criver.com/corporate-governance/highlights</U></FONT>)
which outlines our commitment to sourcing <I>Conflict Minerals </I>responsibly, and our Compliance &amp; Ethics Hotline (available at
1-866-294-3699, or <FONT STYLE="color: blue"><U>http://helpline.criver.com</U></FONT>); and we have provided our suppliers and employees
with access to Assent&rsquo;s Conflict Mineral Resource Centers where tutorials, further education, and other resources can be found
regarding <I>Conflict Minerals </I>and compliance related laws and regulations.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Conclusion based on Reasonable
Country of Origin Inquiry</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">Despite our efforts to date,
including our RCOI and related diligence, and in consideration of the complexity of our supply chain and the Endosafe Products themselves,
we could not determine that our supply chain was not sourcing <I>Conflict Minerals </I>from one or more of the <I>Covered Countries</I>.
While we believe a 98% response rate from our suppliers is significant, we understand further improvements to our evaluation efforts
and diligence practices, as well as increased representations from our suppliers that <I>Conflict Minerals </I>are sourced responsibly,
are needed to maintain and advance this level of engagement with our suppliers and ultimately improve upon the areas where suppliers
stated the source of the <I>Conflict Minerals </I>was either unknown or known to be non-conformant. These improvements over time will
lead to a supply chain that is <I>DRC Conflict Mineral Free</I>; and therefore, we will continue to work with our partners, suppliers
and supplier candidates to further develop our evaluation efforts and diligence practices.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 8.65pt 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Public Conflicts Mineral Disclosure</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">This information is publicly available
at <FONT STYLE="color: blue"><U>www.criver.com</U></FONT> at the SEC filings link on the investor relations page.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>


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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>SIGNATURES</B></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 24.55pt 0pt 34.55pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt"><FONT STYLE="font-size: 10pt">Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the duly authorized
undersigned.</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">CHARLES RIVER LABORATORIES
INTERNATIONAL, INC<FONT STYLE="font-weight: normal">.</FONT></FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/ Matthew Daniel</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%">Name:&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="width: 33%">Matthew Daniel</TD>
    <TD STYLE="width: 38%">&nbsp;</TD>
    <TD STYLE="width: 25%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>Title:</TD>
    <TD>Corporate Senior Vice President, General Counsel, Chief Compliance Officer &amp; Corporate Secretary</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>Date:</TD>
    <TD>May 26, 2022</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt"><FONT STYLE="font-size: 10pt"></FONT>&nbsp;</P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 17.6pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 2pt 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt">Form SD</FONT></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 2pt 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2pt 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt">(Specialized
Disclosure Report)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 2pt 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>


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