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CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY (UNAUDITED) - USD ($) $ in Thousands | Total | Public Offerings, Net of Underwriting Discounts and Commissions and Offering Cost [Member] | Gilead [Member] | Common Shares [Member] | Common Shares [Member] Public Offerings, Net of Underwriting Discounts and Commissions and Offering Cost [Member] | Common Shares [Member] Gilead [Member] | Additional Paid-In Capital [Member] | Additional Paid-In Capital [Member] Public Offerings, Net of Underwriting Discounts and Commissions and Offering Cost [Member] | Additional Paid-In Capital [Member] Gilead [Member] | Accumulated Deficit [Member] | Accumulated Other Comprehensive Income (Loss) [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2022 | $ 247,055 |  |  | $ 4,751 |  |  | $ 870,874 |  |  | $ (598,122) | $ (30,448)
Beginning balance, shares at Dec. 31, 2022 |  |  |  | 46,310,589 |  |  |  |  |  |  |
Exercise of share options and vesting of restricted share units | 217 |  |  | $ 3 |  |  | 214 |  |  |  |
Exercise of share options and vesting of restricted share units, shares |  |  |  | 30,592 |  |  |  |  |  |  |
Share-based compensation | 5,750 |  |  |  |  |  | 5,750 |  |  |  |
Currency translation adjustment | 4,242 |  |  |  |  |  |  |  |  |  | 4,242
Net loss | (39,741) |  |  |  |  |  |  |  |  | (39,741) |
Ending balance at Mar. 31, 2023 | 217,523 |  |  | $ 4,754 |  |  | 876,838 |  |  | (637,863) | (26,206)
Ending balance, shares at Mar. 31, 2023 |  |  |  | 46,341,181 |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2022 | 247,055 |  |  | $ 4,751 |  |  | 870,874 |  |  | (598,122) | (30,448)
Beginning balance, shares at Dec. 31, 2022 |  |  |  | 46,310,589 |  |  |  |  |  |  |
Currency translation adjustment | (6,985) |  |  |  |  |  |  |  |  |  |
Net loss | (94,786) |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2023 | 393,388 |  |  | $ 5,874 |  |  | 1,117,855 |  |  | (692,908) | (37,433)
Ending balance, shares at Sep. 30, 2023 |  |  |  | 57,729,180 |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2023 | 217,523 |  |  | $ 4,754 |  |  | 876,838 |  |  | (637,863) | (26,206)
Beginning balance, shares at Mar. 31, 2023 |  |  |  | 46,341,181 |  |  |  |  |  |  |
Issuance of common share |  | $ 63,719 |  |  | $ 322 |  |  | $ 63,397 |  |  |
Issuance of common share, net, shares |  |  |  |  | 3,272,280 |  |  |  |  |  |
Exercise of share options and vesting of restricted share units | 2,248 |  |  | $ 23 |  |  | 2,225 |  |  |  |
Exercise of share options and vesting of restricted share units, shares |  |  |  | 240,198 |  |  |  |  |  |  |
Share-based compensation | 6,453 |  |  |  |  |  | 6,453 |  |  |  |
Currency translation adjustment | (505) |  |  |  |  |  |  |  |  |  | (505)
Net loss | (32,033) |  |  |  |  |  |  |  |  | (32,033) |
Ending balance at Jun. 30, 2023 | 257,405 |  |  | $ 5,099 |  |  | 948,913 |  |  | (669,896) | (26,711)
Ending balance, shares at Jun. 30, 2023 |  |  |  | 49,853,659 |  |  |  |  |  |  |
Issuance of common share |  | 161,783 |  |  | $ 771 |  |  | 161,012 |  |  |
Issuance of common share, net, shares |  |  |  |  | 7,840,909 |  |  |  |  |  |
Exercise of share options and vesting of restricted share units | 619 |  |  | $ 4 |  |  | 615 |  |  |  |
Exercise of share options and vesting of restricted share units, shares |  |  |  | 34,612 |  |  |  |  |  |  |
Share-based compensation | 7,315 |  |  |  |  |  | 7,315 |  |  |  |
Currency translation adjustment | (10,722) |  |  |  |  |  |  |  |  |  | (10,722)
Net loss | (23,012) |  |  |  |  |  |  |  |  | (23,012) |
Ending balance at Sep. 30, 2023 | 393,388 |  |  | $ 5,874 |  |  | 1,117,855 |  |  | (692,908) | (37,433)
Ending balance, shares at Sep. 30, 2023 |  |  |  | 57,729,180 |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 | 356,343 |  |  | $ 5,883 |  |  | 1,126,054 |  |  | (753,061) | (22,533)
Beginning balance, shares at Dec. 31, 2023 |  |  |  | 57,825,879 |  |  |  |  |  |  |
Issuance of common share |  |  | $ 22,613 |  |  | $ 45 |  |  | $ 22,568 |  |
Issuance of common share, net, shares |  |  |  |  |  | 452,527 |  |  |  |  |
Exercise of share options and vesting of restricted share units | 7,543 |  |  | $ 40 |  |  | 7,503 |  |  |  |
Exercise of share options and vesting of restricted share units, shares |  |  |  | 409,145 |  |  |  |  |  |  |
Share-based compensation | 4,793 |  |  |  |  |  | 4,793 |  |  |  |
Currency translation adjustment | (7,388) |  |  |  |  |  |  |  |  |  | (7,388)
Net loss | (34,456) |  |  |  |  |  |  |  |  | (34,456) |
Ending balance at Mar. 31, 2024 | 349,448 |  |  | $ 5,968 |  |  | 1,160,918 |  |  | (787,517) | (29,921)
Ending balance, shares at Mar. 31, 2024 |  |  |  | 58,687,551 |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 | 356,343 |  |  | $ 5,883 |  |  | 1,126,054 |  |  | (753,061) | (22,533)
Beginning balance, shares at Dec. 31, 2023 |  |  |  | 57,825,879 |  |  |  |  |  |  |
Currency translation adjustment | 15,409 |  |  |  |  |  |  |  |  |  |
Net loss | (184,403) |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2024 | 703,261 |  |  | $ 6,919 |  |  | 1,640,930 |  |  | (937,464) | (7,124)
Ending balance, shares at Sep. 30, 2024 |  |  |  | 68,426,779 |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2024 | 349,448 |  |  | $ 5,968 |  |  | 1,160,918 |  |  | (787,517) | (29,921)
Beginning balance, shares at Mar. 31, 2024 |  |  |  | 58,687,551 |  |  |  |  |  |  |
Issuance of common share |  | 434,530 |  |  | $ 848 |  |  | 433,682 |  |  |
Issuance of common share, net, shares |  |  |  |  | 8,682,500 |  |  |  |  |  |
Exercise of share options and vesting of restricted share units | 10,128 |  |  | $ 47 |  |  | 10,081 |  |  |  |
Exercise of share options and vesting of restricted share units, shares |  |  |  | 482,869 |  |  |  |  |  |  |
Share-based compensation | 11,686 |  |  |  |  |  | 11,686 |  |  |  |
Currency translation adjustment | (8,978) |  |  |  |  |  |  |  |  |  | (8,978)
Net loss | (50,042) |  |  |  |  |  |  |  |  | (50,042) |
Ending balance at Jun. 30, 2024 | 746,772 |  |  | $ 6,863 |  |  | 1,616,367 |  |  | (837,559) | (38,899)
Ending balance, shares at Jun. 30, 2024 |  |  |  | 67,852,920 |  |  |  |  |  |  |
Issuance of common share |  | $ 8 |  |  |  |  |  | $ 8 |  |  |
Exercise of share options and vesting of restricted share units | 11,119 |  |  | $ 56 |  |  | 11,063 |  |  |  |
Exercise of share options and vesting of restricted share units, shares |  |  |  | 573,859 |  |  |  |  |  |  |
Share-based compensation | 13,492 |  |  |  |  |  | 13,492 |  |  |  |
Currency translation adjustment | 31,775 |  |  |  |  |  |  |  |  |  | 31,775
Net loss | (99,905) |  |  |  |  |  |  |  |  | (99,905) |
Ending balance at Sep. 30, 2024 | $ 703,261 |  |  | $ 6,919 |  |  | $ 1,640,930 |  |  | $ (937,464) | $ (7,124)
Ending balance, shares at Sep. 30, 2024 |  |  |  | 68,426,779 |  |  |  |  |  |  |

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