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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2024 | Sep. 30, 2023
CASH FLOWS FROM OPERATING ACTIVITIES: |  |
Net loss | $ (184,403) | $ (94,786)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization of property and equipment | 1,749 | 1,752
Amortization of intangible assets | 133 | 170
Foreign exchange losses (gains) | 13,537 | (3,548)
Share-based compensation expense | 29,971 | 19,518
Amortization (accretion) of discount on investments | (3,129) | (3,899)
Deferred tax expense (benefit) | 363 | 1,340
Changes in operating assets and liabilities: |  |
Accounts receivable | 1,293 | 602
Operating lease right-of-use assets and lease obligations | (74) | (62)
Prepaid expenses and other current assets | (19,930) | (14)
Accounts payable | 1,525 | (4,482)
Accrued expenses and other liabilities | 642 | (1,273)
Deferred revenue | 39,146 | (21,177)
Net cash used in operating activities | (119,177) | (105,859)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |
Purchases of marketable securities | (295,311) | (204,087)
Proceeds from maturities of marketable securities | 154,602 | 183,192
Purchases of intangible assets | (163) | 0
Purchases of property and equipment | (1,647) | (4,008)
Net cash provided by (used in) investing activities | (142,519) | (24,903)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |
Proceeds from issuance of common stock, net | 434,863 | 225,945
Payments of offering costs | (325) | (443)
Proceeds from share issuance - Gilead Collaboration | 22,613 |
Proceeds from share options exercised | 28,790 | 3,084
Net cash provided by financing activities | 485,941 | 228,586
Foreign exchange impact on cash, cash equivalents and restricted cash | 4,513 | (3,648)
Net increase (decrease) in cash, cash equivalents and restricted cash | 228,758 | 94,176
Cash, cash equivalents, and restricted cash, beginning of period | 205,014 | 148,439
Cash, cash equivalents, and restricted cash, end of period | 433,772 | 242,615
SUPPLEMENTAL DISCLOSURES: |  |
Income taxes paid | 2,800 | 3,103
Non-cash purchases of property, equipment and intangibles | 0 | 0
Non-cash financing costs | 0 | 0
Non-cash issuance of stock options | 0 | 0
CASH, CASH EQUIVALENTS AND RESTRICTED CASH |  |
Cash and cash equivalents | 432,998 | 241,868
Restricted cash included in non-current other assets | 774 | 747
Cash, cash equivalents, and restricted cash, end of period | $ 433,772 | $ 242,615

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