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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (184,403) $ (94,786)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization of property and equipment 1,749 1,752
Amortization of intangible assets 133 170
Foreign exchange losses (gains) 13,537 (3,548)
Share-based compensation expense 29,971 19,518
Amortization (accretion) of discount on investments (3,129) (3,899)
Deferred tax expense (benefit) 363 1,340
Changes in operating assets and liabilities:    
Accounts receivable 1,293 602
Operating lease right-of-use assets and lease obligations (74) (62)
Prepaid expenses and other current assets (19,930) (14)
Accounts payable 1,525 (4,482)
Accrued expenses and other liabilities 642 (1,273)
Deferred revenue 39,146 (21,177)
Net cash used in operating activities (119,177) (105,859)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of marketable securities (295,311) (204,087)
Proceeds from maturities of marketable securities 154,602 183,192
Purchases of intangible assets (163) 0
Purchases of property and equipment (1,647) (4,008)
Net cash provided by (used in) investing activities (142,519) (24,903)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock, net 434,863 225,945
Payments of offering costs (325) (443)
Proceeds from share issuance - Gilead Collaboration 22,613  
Proceeds from share options exercised 28,790 3,084
Net cash provided by financing activities 485,941 228,586
Foreign exchange impact on cash, cash equivalents and restricted cash 4,513 (3,648)
Net increase (decrease) in cash, cash equivalents and restricted cash 228,758 94,176
Cash, cash equivalents, and restricted cash, beginning of period 205,014 148,439
Cash, cash equivalents, and restricted cash, end of period 433,772 242,615
SUPPLEMENTAL DISCLOSURES:    
Income taxes paid 2,800 3,103
Non-cash purchases of property, equipment and intangibles 0 0
Non-cash financing costs 0 0
Non-cash issuance of stock options 0 0
CASH, CASH EQUIVALENTS AND RESTRICTED CASH    
Cash and cash equivalents 432,998 241,868
Restricted cash included in non-current other assets 774 747
Cash, cash equivalents, and restricted cash, end of period $ 433,772 $ 242,615