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CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY (UNAUDITED) - USD ($)
$ in Thousands
Total
Public Offerings, Net of Underwriting Discounts and Commissions and Offering Cost [Member]
Gilead [Member]
Common Shares [Member]
Common Shares [Member]
Public Offerings, Net of Underwriting Discounts and Commissions and Offering Cost [Member]
Common Shares [Member]
Gilead [Member]
Additional Paid-In Capital [Member]
Additional Paid-In Capital [Member]
Public Offerings, Net of Underwriting Discounts and Commissions and Offering Cost [Member]
Additional Paid-In Capital [Member]
Gilead [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Beginning balance at Dec. 31, 2022 $ 247,055     $ 4,751     $ 870,874     $ (598,122) $ (30,448)
Beginning balance, shares at Dec. 31, 2022       46,310,589              
Exercise of share options and vesting of restricted share units 217     $ 3     214        
Exercise of share options and vesting of restricted share units, shares       30,592              
Share-based compensation 5,750           5,750        
Currency translation adjustment 4,242                   4,242
Net loss (39,741)                 (39,741)  
Ending balance at Mar. 31, 2023 217,523     $ 4,754     876,838     (637,863) (26,206)
Ending balance, shares at Mar. 31, 2023       46,341,181              
Beginning balance at Dec. 31, 2022 247,055     $ 4,751     870,874     (598,122) (30,448)
Beginning balance, shares at Dec. 31, 2022       46,310,589              
Currency translation adjustment (6,985)                    
Net loss (94,786)                    
Ending balance at Sep. 30, 2023 393,388     $ 5,874     1,117,855     (692,908) (37,433)
Ending balance, shares at Sep. 30, 2023       57,729,180              
Beginning balance at Mar. 31, 2023 217,523     $ 4,754     876,838     (637,863) (26,206)
Beginning balance, shares at Mar. 31, 2023       46,341,181              
Issuance of common share   $ 63,719     $ 322     $ 63,397      
Issuance of common share, net, shares         3,272,280            
Exercise of share options and vesting of restricted share units 2,248     $ 23     2,225        
Exercise of share options and vesting of restricted share units, shares       240,198              
Share-based compensation 6,453           6,453        
Currency translation adjustment (505)                   (505)
Net loss (32,033)                 (32,033)  
Ending balance at Jun. 30, 2023 257,405     $ 5,099     948,913     (669,896) (26,711)
Ending balance, shares at Jun. 30, 2023       49,853,659              
Issuance of common share   161,783     $ 771     161,012      
Issuance of common share, net, shares         7,840,909            
Exercise of share options and vesting of restricted share units 619     $ 4     615        
Exercise of share options and vesting of restricted share units, shares       34,612              
Share-based compensation 7,315           7,315        
Currency translation adjustment (10,722)                   (10,722)
Net loss (23,012)                 (23,012)  
Ending balance at Sep. 30, 2023 393,388     $ 5,874     1,117,855     (692,908) (37,433)
Ending balance, shares at Sep. 30, 2023       57,729,180              
Beginning balance at Dec. 31, 2023 356,343     $ 5,883     1,126,054     (753,061) (22,533)
Beginning balance, shares at Dec. 31, 2023       57,825,879              
Issuance of common share     $ 22,613     $ 45     $ 22,568    
Issuance of common share, net, shares           452,527          
Exercise of share options and vesting of restricted share units 7,543     $ 40     7,503        
Exercise of share options and vesting of restricted share units, shares       409,145              
Share-based compensation 4,793           4,793        
Currency translation adjustment (7,388)                   (7,388)
Net loss (34,456)                 (34,456)  
Ending balance at Mar. 31, 2024 349,448     $ 5,968     1,160,918     (787,517) (29,921)
Ending balance, shares at Mar. 31, 2024       58,687,551              
Beginning balance at Dec. 31, 2023 356,343     $ 5,883     1,126,054     (753,061) (22,533)
Beginning balance, shares at Dec. 31, 2023       57,825,879              
Currency translation adjustment 15,409                    
Net loss (184,403)                    
Ending balance at Sep. 30, 2024 703,261     $ 6,919     1,640,930     (937,464) (7,124)
Ending balance, shares at Sep. 30, 2024       68,426,779              
Beginning balance at Mar. 31, 2024 349,448     $ 5,968     1,160,918     (787,517) (29,921)
Beginning balance, shares at Mar. 31, 2024       58,687,551              
Issuance of common share   434,530     $ 848     433,682      
Issuance of common share, net, shares         8,682,500            
Exercise of share options and vesting of restricted share units 10,128     $ 47     10,081        
Exercise of share options and vesting of restricted share units, shares       482,869              
Share-based compensation 11,686           11,686        
Currency translation adjustment (8,978)                   (8,978)
Net loss (50,042)                 (50,042)  
Ending balance at Jun. 30, 2024 746,772     $ 6,863     1,616,367     (837,559) (38,899)
Ending balance, shares at Jun. 30, 2024       67,852,920              
Issuance of common share   $ 8           $ 8      
Exercise of share options and vesting of restricted share units 11,119     $ 56     11,063        
Exercise of share options and vesting of restricted share units, shares       573,859              
Share-based compensation 13,492           13,492        
Currency translation adjustment 31,775                   31,775
Net loss (99,905)                 (99,905)  
Ending balance at Sep. 30, 2024 $ 703,261     $ 6,919     $ 1,640,930     $ (937,464) $ (7,124)
Ending balance, shares at Sep. 30, 2024       68,426,779