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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0000898432-08-000069.txt : 20080201
<SEC-HEADER>0000898432-08-000069.hdr.sgml : 20080201
<ACCEPTANCE-DATETIME>20080201120304
ACCESSION NUMBER:		0000898432-08-000069
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20080201
DATE AS OF CHANGE:		20080201
GROUP MEMBERS:		BIOTECHNOLOGY VALUE FUND II, L.P.
GROUP MEMBERS:		BVF INC.
GROUP MEMBERS:		BVF INVESTMENTS, L.L.C.
GROUP MEMBERS:		BVF PARTNERS L.P.
GROUP MEMBERS:		INVESTMENT 10, L.L.C.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			REPLIGEN CORP
		CENTRAL INDEX KEY:			0000730272
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				042729386
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0331

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-38071
		FILM NUMBER:		08567006

	BUSINESS ADDRESS:	
		STREET 1:		41 SEYON STREET
		STREET 2:		BUILDING 1, SUITE 100
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453
		BUSINESS PHONE:		7814499560

	MAIL ADDRESS:	
		STREET 1:		41 SEYON STREET
		STREET 2:		BUILDING 1, SUITE 100
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND L P
		CENTRAL INDEX KEY:			0000918923
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		IRS NUMBER:				363924731
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		900 N. MICHIGAN AVENUE, SUITE 1100
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		900 N. MICHIGAN AVENUE, SUITE 1100
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>repligen13ga.htm
<TEXT>
<HTML>
<HEAD>
<TITLE></TITLE>
</HEAD>
<BODY style="line-height:12pt; font-family:Times New Roman; font-size:10pt; color:#000000">
<DIV style="width:624px"><P style="margin:0px; padding:4px; border-top:1px solid #000000; border-bottom:1px solid #000000"><BR></P>
<P style="line-height:normal; margin:0px; font-size:16px" align=center><B>SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, DC 20549</B></P>
<P style="margin:0px" align=center><BR></P>
<P style="line-height:normal; margin:0px; font-size:18px" align=center><B>SCHEDULE 13G<BR>
(Rule&nbsp;13d-102)</B></P>
<P style="margin:0px" align=center><BR></P>
<P style="line-height:18.667px; margin:0px; font-size:16px" align=center><B>INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT<BR>
TO RULES 13d-1(b) (c)&nbsp;AND (d)&nbsp;AND AMENDMENTS THERETO FILED<BR>
PURSUANT TO 13d-2(b)</B></P>
<P style="margin:0px" align=center><BR></P>
<P style="margin:0px" align=center><B>(Amendment No. 3)*<BR>
</B></P>
<TABLE style="font-size:13.333px" cellspacing=0 align=center><TR><TD width=393.133></TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>Repligen Corporation</B></P>
<P style="margin:0px" align=center>(Name of Issuer)</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>Common Stock</B></P>
<P style="margin:0px" align=center>(Title of Class of Securities)</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px"><BR>
&nbsp;</P>
</TD><A NAME="OLE_LINK1"></A><A NAME="OLE_LINK2"></A><A NAME="OLE_LINK3"></A></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>759916109</B></P>
<P style="margin:0px" align=center>(CUSIP Number)</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=393.133><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>December 31, 2007</B></P>
<P style="margin:0px" align=center>(Date of Event Which Requires Filing of this Statement)</P>
</TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px">Check the appropriate box to designate the rule pursuant to which this Schedule is filed: </P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=19></TD><TD width=14.2></TD><TD width=441.067></TD></TR>
<TR><TD valign=top width=19><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=14.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=441.067><P style="margin:0px; font-family:Wingdings"><FONT FACE="Wingdings">o</FONT><FONT FACE="Times New Roman"> Rule&nbsp;13d-1(b)<BR>
</FONT>&#253;<FONT FACE="Times New Roman"> Rule&nbsp;13d-1(c)<BR>
</FONT>o<FONT FACE="Times New Roman"> Rule&nbsp;13d-1(d)</FONT></P>
</TD></TR>
</TABLE>
<P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000"><BR></P>
<P style="margin-top:5.533px; margin-bottom:5.533px; text-indent:48px"><FONT FACE="Times New Roman">*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</FONT></P>
<P style="margin-top:6.667px; margin-bottom:6.667px; text-indent:48px">The information required on the remainder of this cover page shall not be deemed to be &quot;filed&quot; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, <I>see</I> the <I>Notes</I>). </P>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131><P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000" align=center><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 2 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>Biotechnology Value Fund, L.P.<BR>
</B> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=580.333 colspan=3><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=511.667><P style="line-height:18.667px; margin:0px; font-size:16px">&nbsp;</P>
<P style="margin:0px"><B>Delaware</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.333></TD><TD width=6.267></TD><TD width=75></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;515,750</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;515,750</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;515,750</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;&nbsp;<B>1.7%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-bottom:2px solid #000000" valign=top width=43.333><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-bottom:2px solid #000000" valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;</B></P>
<P style="margin:0px"><B>&nbsp;PN</B></P>
</TD><TD style="border-bottom:2px solid #000000" valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-bottom:2px solid #000000" valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131><P style="margin:0px" align=center><B>CUSIP No.&nbsp;759916109</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 3 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>1</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>Biotechnology Value Fund II, L.P.<BR>
</B> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=49.933><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=511.667><P style="line-height:18.667px; margin:0px; font-size:16px">&nbsp;</P>
<P style="margin:0px"><B>&nbsp;Delaware</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.333></TD><TD width=6.267></TD><TD width=75></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;325,400</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;325,400</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;</B></P>
<P style="margin:0px"><B>&nbsp;325,400</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><FONT FACE="Times New Roman"><B>11</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;1.1%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;TYPE OF REPORTING PERSON*</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;</B></P>
<P style="margin:0px"><B>PN</B></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=43.333><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=518.2 colspan=5><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.467></TD><TD width=6.267></TD><TD width=81></TD><TD width=6.333></TD><TD width=12.333></TD><TD width=6.333></TD><TD width=31.067></TD><TD width=6.267></TD><TD width=293.4></TD><TD width=18.733></TD><TD width=56.133></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD valign=top width=131.067 colspan=4><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8 colspan=3><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131.067 colspan=4><P style="margin:0px" align=center><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733 colspan=3><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8 colspan=3><P style="margin:0px; padding-top:4px; padding-bottom:4px; border-top:2px solid #000000; border-bottom:2px solid #000000" align=center><B>Page 4 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131.067 colspan=4><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8 colspan=3><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=13><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>BVF Investments, L.L.C.<BR>
 </B>I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=13><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=13><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=13><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.6 colspan=9><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.467><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=511.6 colspan=9><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;Delaware</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=13><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.6 colspan=8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px"><B>&nbsp;1,116,700</B></P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.6 colspan=8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.6 colspan=8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.733 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.667 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=5><P style="margin:0px"><B>&nbsp;1,116,700</B></P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.333></TD><TD width=6.267></TD><TD width=518.2></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
<P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.2><P style="margin:0px"><B>&nbsp;</B></P>
<P style="margin:0px"><B>&nbsp;1,116,700</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2><P style="margin:0px"><B>&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.2><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><FONT FACE="Times New Roman">&nbsp;</FONT></P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2><P style="margin:0px"><B>&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.2><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;3.6%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
<P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.2><P style="margin:0px"><B>&nbsp;</B></P>
<P style="margin:0px"><B>&nbsp;OO</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131><P style="margin:0px"><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px" align=center>&nbsp;<B><BIG>13G</BIG></B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=124.8><P style="margin:0px" align=center><B>Page 5 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=511.667></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>Investment 10, L.L.C.<BR>
 </B>I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=511.667><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=49.933><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=511.667><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;Illinois</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=49.933><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.467></TD><TD width=6.267></TD><TD width=74.867></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.733></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;123,100</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.667 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.6 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=436.933 colspan=3><P style="margin:0px"><B>&nbsp;123,100</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:18.667px; margin:0px; font-size:16px">&nbsp;</P>
<P style="margin:0px"><B>123,100</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.067 colspan=5><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;0.4%</B></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.467><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.067 colspan=5><P style="line-height:18.667px; margin:0px; font-size:16px">&nbsp;</P>
<P style="margin:0px"><B>&nbsp;OO</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.267></TD><TD width=87.333></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=56.133></TD><TD width=18.733></TD><TD width=49.933></TD></TR>
<TR><TD valign=top width=131 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8 colspan=3><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131 colspan=3><P style="margin:0px" align=center><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px" align=center>&nbsp;<B><BIG>13G</BIG></B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=124.8 colspan=3><P style="margin:0px" align=center><B>Page 6 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8 colspan=3><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=131 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000" valign=top width=124.8 colspan=3><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667 colspan=5><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>BVF Partners L.P.<BR>
</B> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667 colspan=5><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667 colspan=5><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667 colspan=5><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667 colspan=5><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=511.667 colspan=5><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=49.933><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.667 colspan=5><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=511.667 colspan=5><P style="line-height:18.667px; margin:0px; font-size:16px">&nbsp;</P>
<P style="margin:0px"><B>&nbsp;Delaware</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=43.333></TD><TD width=6.267></TD><TD width=74.867></TD><TD width=18.733></TD><TD width=37.467></TD><TD width=6.267></TD><TD width=380.867></TD><TD width=18.733></TD><TD width=37.467></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;2,080,950</B></P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.467 colspan=3><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.067 colspan=3><P style="margin:0px"><B>&nbsp;2,080,950</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><B>&nbsp;</B></P>
<P style="margin:0px"><B>&nbsp;2,080,950</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><FONT FACE="Times New Roman"><B>&nbsp;</B></FONT></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=37.467><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>11</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;</B></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;6.7%</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px">&nbsp;TYPE OF REPORTING PERSON*</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.467><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.333><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.2 colspan=5><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;PN</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.467><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=9><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=37.4></TD><TD width=6.2></TD><TD width=6.267></TD><TD width=74.533></TD><TD width=6.6></TD><TD width=12.133></TD><TD width=6.6></TD><TD width=30.8></TD><TD width=6.267></TD><TD width=293.667></TD><TD width=18.733></TD><TD width=56.133></TD><TD width=12.6></TD><TD width=6.133></TD><TD width=12.6></TD><TD width=37.333></TD></TR>
<TR><TD valign=top width=131 colspan=5><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131 colspan=5><P style="margin:0px" align=center><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733 colspan=3><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=124.8 colspan=5><P style="margin:0px" align=center><B>Page 7 of 10 pages</B></P>
</TD></TR>
<TR><TD valign=top width=131 colspan=5><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=131 colspan=5><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=131 colspan=5><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733 colspan=3><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8 colspan=5><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>1</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px">&nbsp;NAME OF REPORTING PERSON:<BR>
 <B>BVF Inc.<BR>
</B> S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>2</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px">&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px" align=right>(a)&nbsp;&nbsp;<FONT FACE="Wingdings">&#253;</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px" align=right>(b)&nbsp;&nbsp;<FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>3</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px">&nbsp;SEC USE ONLY</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px"><BR>
<B>&nbsp;</B></P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px"><BR>
&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>4</B></P>
</TD><TD valign=top width=6.2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=511.733 colspan=10><P style="margin:0px">&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=49.933 colspan=2><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=37.4><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=511.733 colspan=10><P style="line-height:18.667px; margin:0px; font-size:16px">&nbsp;</P>
<P style="line-height:normal; margin:0px; font-size:16px">&nbsp;<B>Delaware</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=49.933 colspan=2><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>5</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px">&nbsp;SOLE VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>NUMBER OF</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>SHARES</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.867 colspan=10><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>BENEFICIALLY</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>6</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px">&nbsp;SHARED VOTING POWER</P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>OWNED</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px"><B>&nbsp;2,080,950</B></P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>BY</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.867 colspan=10><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>EACH</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>7</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px">&nbsp;SOLE DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>REPORTING</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px"><B>&nbsp;0</B></P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>PERSON</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=480.867 colspan=10><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>WITH:</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center><B>8</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px">&nbsp;SHARED DISPOSITIVE POWER</P>
</TD></TR>
<TR><TD valign=top width=124.4 colspan=4><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.4 colspan=2><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=437.2 colspan=7><P style="margin:0px"><B>&nbsp;2,080,950</B></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>9</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=10><P style="margin:0px">&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.333><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.067 colspan=10><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;2,080,950</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.333><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>10</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=10><P style="margin:0px">&nbsp;CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.333><P style="margin:0px; font-family:Wingdings" align=right><FONT FACE="Wingdings">o</FONT></P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.067 colspan=10><P style="margin:0px"><BR></P>
</TD><TD valign=top width=18.733 colspan=2><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=37.333><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><FONT FACE="Times New Roman"><B>11</B></FONT></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=10><P style="margin:0px">&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.333><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>&nbsp;</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px"><BR></P>
</TD><TD valign=top width=518.067 colspan=10><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;6.7%</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px"><BR></P>
</TD><TD valign=top width=37.333><P style="margin:0px"><BR></P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><B>12</B></P>
</TD><TD valign=top width=6.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=518.067 colspan=10><P style="margin:0px"><B>&nbsp;TYPE OF REPORTING PERSON*</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.333><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD valign=top width=43.6 colspan=2><P style="margin:0px" align=center><BR></P>
</TD><TD valign=top width=6.267><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=518.067 colspan=10><P style="margin:0px"><BR></P>
<P style="margin:0px"><B>&nbsp;IA, CO</B></P>
</TD><TD valign=top width=18.733 colspan=2><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=37.333><P style="margin:0px">&nbsp;</P>
</TD></TR>
<TR><TD style="border-top:2px solid #000000" valign=top width=624 colspan=16><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131><P style="margin:0px" align=center><B>CUSIP No.&nbsp;759916109</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px" align=center>&nbsp;<B><BIG>13G</BIG></B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=124.8><P style="margin:0px" align=center><B>Page 8 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 1(a).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NAME OF ISSUER:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Repligen Corporation (&#147;Repligen&#148;)</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 1(b).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:</B></P>
<P style="margin-top:0px; margin-bottom:-16px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
<P style="margin:0px; text-indent:48px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;41 Seyon Street</P>
<P style="margin:0px; text-indent:96px">Building 1, Suite 100</P>
<P style="margin:0px; text-indent:96px">Waltham, MA 02453</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(a).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NAME OF PERSON FILING:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Amendment No. 3 to Schedule 13G is being filed on behalf of the following persons (the &quot;Reporting Persons&quot;):</P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=87.333></TD><TD width=31.2></TD><TD width=18.733></TD><TD width=486.733></TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(i)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;Biotechnology Value Fund, L.P. (&quot;BVF&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(ii)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;Biotechnology Value Fund II, L.P. (&quot;BVF2&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(iii)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;BVF Investments, L.L.C. (&quot;Investments&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(iv)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;Investment 10, L.L.C. (&quot;ILL10&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(v)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;BVF Partners L.P. (&quot;Partners&quot;)</P>
</TD></TR>
<TR><TD valign=top width=87.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=31.2><P style="margin:0px" align=center>(vi)</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=486.733><P style="margin:0px">&nbsp;BVF&nbsp;Inc. (&quot;BVF&nbsp;Inc.&quot;)</P>
</TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(b).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ADDRESS OF PRINCIPAL BUSINESS OFFICE:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The principal business office of the Reporting Persons comprising the group filing this Amendment No. 3 to Schedule&nbsp;13G is located at 900 North Michigan Avenue, Suite 1100, Chicago, Illinois, 60611.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(c).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CITIZENSHIP:</B></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=68.6></TD><TD width=18.733></TD><TD width=112.333></TD><TD width=424.333></TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;BVF:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited partnership</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;BVF2:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited partnership</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;Investments:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited liability company</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;ILL10:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;an Illinois limited liability company</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;Partners:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware limited partnership</P>
</TD></TR>
<TR><TD valign=top width=68.6><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=112.333><P style="margin:0px">&nbsp;BVF&nbsp;Inc.:</P>
</TD><TD valign=top width=424.333><P style="margin:0px">&nbsp;a Delaware corporation</P>
</TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(d).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;TITLE OF CLASS OF SECURITIES:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Amendment No. 3 to Schedule 13G is being filed with respect to the common stock, par value $0.01 per share (&quot;Common Stock&quot;), of Repligen. &nbsp;The Reporting Persons' percentage ownership of Common Stock is based on 30,916,534 shares of Common Stock being outstanding. </P>
<P style="margin-top:5.533px; margin-bottom:-16px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
<P style="margin-top:0px; margin-bottom:5.533px; text-indent:72px">&nbsp;&nbsp;&nbsp;&nbsp;As of December 31, 2007 BVF beneficially owned 515,750 shares of Common Stock, BVF2 beneficially owned 325,400 shares of Common Stock, Investments beneficially owned 1,116,700 shares of Common Stock and ILL10 beneficially owned 123,100 shares of Common Stock. &nbsp;Beneficial ownership by Partners and BVF Inc. includes 2,080,950 shares of &nbsp;Common Stock.</P>
<P style="margin:6.667px"><BR></P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 2(e).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CUSIP Number:</B></P>
<P style="line-height:normal; margin:0px; padding-bottom:4px; font-size:16px; border-bottom:2px solid #000000">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>759916109</B></P>
<P style="margin:0px; padding-bottom:4px; border-bottom:2px solid #000000"><BR></P>
<P style="margin:0px; padding-top:4px; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131><P style="margin:0px" align=center><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px" align=center>&nbsp;<B><BIG>13G</BIG></B></P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=124.8><P style="margin:0px" align=center><B>Page 9 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), or 13d-2(b) or (c)&nbsp;CHECK WHETHER THE PERSON FILING IS: &nbsp;&nbsp;&nbsp;One of the following</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable as this Amendment No. 3 to Schedule&nbsp;13G is filed pursuant to Rule&nbsp;13d-1(c).</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The information in items 1 and 5 through 11 on the cover pages (pp. 2&nbsp;-&nbsp;7) on this Amendment No. 3 to Schedule&nbsp;13G is hereby incorporated by reference.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following.&nbsp;</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:</B></P>
<P style="margin-top:5.533px; margin-bottom:5.533px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to the operating agreement of Investments, Partners is authorized, among other things, to invest the funds of Ziff Asset Management, L.P., the majority member of Investments, in shares of the Common Stock beneficially owned by Investments and to vote and exercise dispositive power over those shares of the Common Stock. Partners and BVF&nbsp;Inc. share voting and dispositive power over shares of the Common Stock beneficially owned by BVF, BVF2, Investments and those owned by ILL10, on whose behalf Partners acts as an investment manager and, accordingly, Partners and BVF&nbsp;Inc. have beneficial ownership of all of the shares of the Common Stock owned by such parties.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOTICE OF DISSOLUTION OF GROUP:</B></P>
<P style="margin-top:5.533px; margin-bottom:5.533px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.</P>
<P style="margin:0px"><BR>
<BR></P>
<P style="margin:0px; padding-top:4px; page-break-before:always; border-top:2px solid #000000"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=131></TD><TD width=18.733></TD><TD width=330.733></TD><TD width=18.733></TD><TD width=124.8></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=131><P style="margin:0px" align=center><B>CUSIP No. 759916109</B></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="line-height:20.667px; margin:0px; font-size:18px" align=center><B>13G</B></P>
</TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD style="border-top:2px solid #000000; border-bottom:2px solid #000000" valign=top width=124.8><P style="margin:0px" align=center><B>Page 10 of 10 Pages</B></P>
</TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=330.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
<TR><TD valign=top width=131><P style="font-size:2pt">&nbsp;</P></TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=330.733><P style="margin:0px" align=center>&nbsp;</P>
</TD><TD valign=top width=18.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=124.8><P style="font-size:2pt">&nbsp;</P></TD></TR>
</TABLE>
<P style="margin-top:6.667px; margin-bottom:6.667px"><B>ITEM 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CERTIFICATION</B></P>
<P style="margin-top:6.667px; margin-bottom:6.667px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. </P>
<P style="margin-top:5.533px; margin-bottom:5.533px">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. </P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=74></TD><TD width=7></TD><TD width=543></TD></TR>
<TR><TD valign=top width=74><P style="margin:0px">Dated:</P>
</TD><TD valign=top width=7><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=543><P style="margin:0px">February 1, 2008</P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=35.733></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=193.133></TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=260.933 colspan=7><P style="margin:0px"><BR>
<B>BIOTECHNOLOGY VALUE FUND, L.P.</B></P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=238.333 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=215.733 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=193.133><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=193.133><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=260.933 colspan=7><P style="margin:0px"><BR>
<B>BIOTECHNOLOGY VALUE FUND II, L.P.</B></P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=238.333 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=215.733 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=193.133><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=193.133><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=260.933 colspan=7><P style="margin:0px"><BR>
<B>BVF INVESTMENTS, L.L.C.</B></P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=238.333 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its manager</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=215.733 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=193.133><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=35.733><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=193.133><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 &nbsp;President</P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<TABLE style="font-size:13.333px" cellspacing=0><TR><TD width=6.8></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=19.267></TD><TD width=3.333></TD><TD width=222.067></TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=289.867 colspan=7><P style="margin:0px"><BR>
<B>INVESTMENT 10, L.L.C.</B></P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=267.267 colspan=5><P style="margin:0px"><BR>
BVF Partners L.P., its attorney-in-fact</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=244.667 colspan=3><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=222.067><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=289.867 colspan=7><P style="margin:0px"><BR>
<B>BVF PARTNERS L.P.</B></P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=267.267 colspan=5><P style="margin:0px"><BR>
BVF Inc., its general partner</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=289.867 colspan=7><P style="margin:0px"><BR></P>
<P style="margin:0px"><BR>
<B>BVF INC.</B></P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px"><BR>
By:</P>
</TD><TD valign=top width=3.333><P style="margin:0px"><BR>
&nbsp;</P>
</TD><TD valign=top width=222.067><P style="margin:0px"><BR>
&nbsp;/s/ Mark N. Lampert</P>
</TD></TR>
<TR><TD valign=top width=6.8><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=19.267><P style="margin:0px">&nbsp;</P>
</TD><TD valign=top width=3.333><P style="margin:0px">&nbsp;</P>
</TD><TD style="border-top:2px solid #000000" valign=top width=222.067><P style="margin:0px"><BR></P>
<P style="margin:0px">&nbsp;Mark N. Lampert<BR>
 President</P>
</TD></TR>
</TABLE>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><BR></P>
<P style="margin:0px"><BR>
<BR></P>
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