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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 jVP7t2w63YZbOj/Uil5Fag==

<SEC-DOCUMENT>0000898432-09-000125.txt : 20090130
<SEC-HEADER>0000898432-09-000125.hdr.sgml : 20090130
<ACCEPTANCE-DATETIME>20090130161457
ACCESSION NUMBER:		0000898432-09-000125
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20090130
DATE AS OF CHANGE:		20090130
GROUP MEMBERS:		BIOTECHNOLOGY VALUE FUND II, L.P.
GROUP MEMBERS:		BVF INC.
GROUP MEMBERS:		BVF INVESTMENTS, L.L.C.
GROUP MEMBERS:		BVF PARTNERS L.P.
GROUP MEMBERS:		INVESTMENT 10, L.L.C.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			REPLIGEN CORP
		CENTRAL INDEX KEY:			0000730272
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				042729386
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0331

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-38071
		FILM NUMBER:		09558495

	BUSINESS ADDRESS:	
		STREET 1:		41 SEYON STREET
		STREET 2:		BUILDING 1, SUITE 100
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453
		BUSINESS PHONE:		7814499560

	MAIL ADDRESS:	
		STREET 1:		41 SEYON STREET
		STREET 2:		BUILDING 1, SUITE 100
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND L P
		CENTRAL INDEX KEY:			0000918923
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		IRS NUMBER:				363924731
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		900 N. MICHIGAN AVENUE, SUITE 1100
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		900 N. MICHIGAN AVENUE, SUITE 1100
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>bvf_repligen13g-a.htm
<TEXT>
<html>
    <head>
        <title></title>
    </head>

    <body text="#000000" vlink="#800000" link="#0000ff" bgcolor="#ffffff">
        <div style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; WIDTH: 600px; TEXT-INDENT: 72px">
            <p></p>

            <p style="MARGIN-TOP: 0pt; FONT-SIZE: 12pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><a name="OLE_LINK1"></a></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">SECURITIES AND EXCHANGE COMMISSION<br>
            </font></b><b><font style="FONT-SIZE: 10pt">Washington, DC 20549<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">SCHEDULE 13G<br>
            </font></b><b><font style="FONT-SIZE: 10pt">(Rule&nbsp;13d-102)<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT<br>
            TO RULES 13d-1(b) (c)&nbsp;AND (d)&nbsp;AND AMENDMENTS THERETO FILED<br>
            PURSUANT TO 13d-2(b)<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></b><b><font style="FONT-SIZE: 10pt">(Amendment No. 4)*<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <table cellspacing="0" cellpadding="0" width="63%" align="center" border="0">
                <tr>
                    <td valign="top" width="100%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">Repligen Corporation</font></b></p>

                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(Name of Issuer)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="100%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="100%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">Common Stock</font></b></p>

                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(Title of Class of Securities)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="100%"><br>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="100%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">759916109</font></b></p>

                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(CUSIP Number)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="100%"><br>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="100%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">December 31, 2008</font></b></p>

                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(Date of Event Which Requires Filing of this Statement)</font></p>
                    </td>
                </tr>
            </table>
            <br>
            <br>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</font></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="600" border="0">
                <tr>
                    <td valign="top" width="4%">&nbsp;</td>

                    <td valign="top" width="36">
                        <p align="right"><font face="Wingdings" size="+0"><font face="Wingdings" size="+0"><font face="Wingdings" size="+0">o</font></font></font></p>
                    </td>

                    <td valign="top" width="402">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Rule&nbsp;13d-1(b)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="4%">
                    </td>

                    <td valign="top" width="36">
                        <p align="right"><font face="Wingdings" size="+0">x</font></p>
                    </td>

                    <td valign="top" width="402"><font size="2">Rule&nbsp;13d-1(c)</font></td>
                </tr>

                <tr>
                    <td valign="top" width="4%">
                    </td>

                    <td valign="top" width="36">
                        <p align="right"><font face="Wingdings" size="+0">o</font></p>
                    </td>

                    <td valign="top" width="402"><font size="2">Rule&nbsp;13d-1(d)</font></td>
                </tr>

                <tr>
                    <td style="BORDER-BOTTOM: black 2px solid" valign="top" width="4%">&nbsp;&nbsp;&nbsp;</td>

                    <td style="BORDER-BOTTOM: black 2px solid" valign="top" width="36">
                        <p align="right">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p>
                    </td>

                    <td style="BORDER-BOTTOM: black 2px solid" valign="top" width="402">&nbsp;&nbsp;&nbsp;&nbsp;</td>
                </tr>
            </table>
            <br>

            <p></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">*The remainder of this cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 29pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">The information required on the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,</font> <font style="FONT-SIZE: 10pt">see</font>
            <font style="FONT-SIZE: 10pt">the</font> <font style="FONT-SIZE: 10pt">Notes).</font></p>
            <!-- NEXT PAGE SECTION BREAK  -->

            <div title="EE+ Page Break" style="FONT-SIZE: 1pt; PAGE-BREAK-AFTER: always; WIDTH: 100%; HEIGHT: 1px">
            </div>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="30%" colspan="3">&nbsp;</td>

                    <td style="BORDER-TOP: #000000 2px solid" valign="top" width="0%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="45%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="0%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="22%" colspan="3">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="30%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">CUSIP No. 759916109</font></b></p>
                    </td>

                    <td valign="top" width="0%">&nbsp;</td>

                    <td valign="top" width="45%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="0%">&nbsp;</td>

                    <td valign="top" width="22%" colspan="3">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">Page 2 of 10 Pages</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-BOTTOM: black 2px solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">1</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">NAME OF REPORTING PERSON:<br>
                        </font><b><font style="FONT-SIZE: 10pt">Biotechnology Value Fund, L.P.</font></b><br>
                        <font style="FONT-SIZE: 10pt">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">2</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(a) <font face="Wingdings" size="+0">x</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="5">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(b)&nbsp;<font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="5">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">3</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SEC USE ONLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%" colspan="5"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="8%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">4</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" colspan="7">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</font></p>
                    </td>
                </tr>

                <tr style="BORDER-BOTTOM: #000000 2px solid">
                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="6%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="1%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        Delaware</font></b></p>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="3%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="8%"><br>
                    </td>
                </tr>
            </table>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">5</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">NUMBER OF</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">SHARES</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BENEFICIALLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">6</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">OWNED</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">667,150</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">EACH</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">7</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">REPORTING</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">WITH:</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">8</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">667,150</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">9</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        667,150</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">10</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font face="Wingdings" size="+0">o</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">11</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        2.14%</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">12</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">TYPE OF REPORTING PERSON*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-BOTTOM: black 1.5pt solid" valign="top" width="6%">&nbsp;</td>

                    <td style="BORDER-BOTTOM: black 1.5pt solid" valign="top" width="1%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1.5pt solid" valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">PN</font></b></p>
                    </td>

                    <td style="BORDER-BOTTOM: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-BOTTOM: black 1.5pt solid" valign="top" width="6%">&nbsp;</td>
                </tr>
            </table>
            <!-- NEXT PAGE SECTION BREAK  --><br>
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                <hr align="left" noshade>
            </div>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="160">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="18">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="278">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="21%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="160">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">CUSIP No.&nbsp;759916109</font></b></p>
                    </td>

                    <td valign="top" width="18">&nbsp;</td>

                    <td valign="top" width="278">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="21%">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">Page 3 of 10 Pages</font></b></p>
                    </td>
                </tr>
            </table>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="6%">
                        <p style="BORDER-TOP: #000000 2px solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">1</font></p>
                    </td>

                    <td style="BORDER-TOP: #000000 2px solid" valign="top" width="1%">&nbsp;</td>

                    <td style="BORDER-TOP: #000000 2px solid" valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">NAME OF REPORTING PERSON:<br>
                        </font><b><font style="FONT-SIZE: 10pt">Biotechnology Value Fund II, L.P.</font></b><br>
                        <font style="FONT-SIZE: 10pt">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</font></p>
                    </td>

                    <td style="BORDER-TOP: #000000 2px solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: #000000 2px solid" valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">2</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(a) <font face="Wingdings" size="+0">x</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(b) <font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">3</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SEC USE ONLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="9%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">4</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="6%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="1%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        Delaware</font></b></p>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="3%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="9%"><br>
                    </td>
                </tr>
            </table>
            <br>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">5</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">NUMBER OF</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">SHARES</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BENEFICIALLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">6</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">OWNED</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">425,400</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">EACH</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">7</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">REPORTING</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">WITH:</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">8</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">425,400</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">9</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        425,400</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">10</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt"><font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">11</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        1.36%</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr style="HEIGHT: 4pt">
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">12</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">TYPE OF REPORTING PERSON*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        PN</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="6%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="1%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="83%" colspan="5">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="6%">&nbsp;</td>
                </tr>
            </table>
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            </div>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="21%" colspan="4">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="3">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="20%" colspan="3">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="21%" colspan="4">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">CUSIP No. 759916109</font></b></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="53%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="20%" colspan="3">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">Page 4 of 10 Pages</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="21%" colspan="4">&nbsp;</td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="53%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="20%" colspan="3">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="13">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">1</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="9">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">NAME OF REPORTING PERSON:<br>
                        </font><b><font style="FONT-SIZE: 10pt">BVF Investments, L.L.C.<br>
                        </font></b><font style="FONT-SIZE: 10pt">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="13">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">2</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="9">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(a)&nbsp;<font face="Wingdings" size="+0">x</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="9">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(b) <font face="Wingdings" size="3">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="9">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="13">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">3</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="9">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SEC USE ONLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%" colspan="9"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="8%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="13">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">4</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="9">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%" colspan="9">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        Delaware</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="8%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="13">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">5&nbsp;&nbsp;</font></b></p>
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">&nbsp;<font style="FONT-SIZE: 10pt">SOLE VOTING POWER</font></td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">NUMBER OF</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">&nbsp;</td>

                    <td valign="top">
                    </td>

                    <td valign="top" width="40">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">SHARES</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="8">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BENEFICIALLY</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">6&nbsp;&nbsp;</font></b></p>
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">&nbsp;<font style="FONT-SIZE: 10pt">SHARED VOTING POWER</font></td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>
                </tr>

                <tr height="19">
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">OWNED</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">&nbsp;</td>

                    <td valign="top">
                    </td>

                    <td valign="top" width="40">&nbsp;<b><font style="FONT-SIZE: 10pt">1,476,700</font></b></td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BY</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="8">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">EACH</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">7&nbsp;&nbsp;</font></b></p>
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE DISPOSITIVE POWER</font></p>
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">REPORTING</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">&nbsp;</td>

                    <td valign="top">
                    </td>

                    <td valign="top" width="40">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">PERSON</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="8">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">WITH:</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">8&nbsp;&nbsp;</font></b></p>
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED DISPOSITIVE POWER</font></p>
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>

                    <td valign="top">
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="32">&nbsp;</td>

                    <td valign="top">
                    </td>

                    <td valign="top" width="40">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">1,476,700</font></b></p>
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>

                    <td valign="top" width="40">
                    </td>
                </tr>
            </table>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">9</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="7%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        1,476,700</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="7%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">10</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="7%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt"><font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="7%">
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td style="LINE-HEIGHT: normal" valign="top" width="83%">
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="7%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">11</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="7%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        4.74</font></b><b><font style="FONT-SIZE: 10pt">%</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="7%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">12</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">TYPE OF REPORTING PERSON*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="7%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="7%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        OO</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="7%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>
            </table>
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            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="168">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="8">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="280">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="21%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="168">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">CUSIP No. 759916109</font></b></p>
                    </td>

                    <td valign="top" width="8">&nbsp;</td>

                    <td valign="top" width="280">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: #000000 2px solid; BORDER-BOTTOM: #000000 2px solid" valign="top" width="21%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">Page 5 of 10 Pages</font></b></p>
                    </td>
                </tr>
            </table>
            <br>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">1</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">NAME OF REPORTING PERSON:<br>
                        </font><b><font style="FONT-SIZE: 10pt">Investment 10, L.L.C.<br>
                        </font></b><font style="FONT-SIZE: 10pt">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">2</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(a)&nbsp;&nbsp;<font face="Wingdings" size="+0">x</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(b)&nbsp;&nbsp;<font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">3</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SEC USE ONLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="9%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">4</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="9%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="6%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="1%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        Illinois</font></b></p>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="3%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: black 1px solid" valign="top" width="9%"><br>
                    </td>
                </tr>
            </table>
            <br>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">5</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">NUMBER OF</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">SHARES</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BENEFICIALLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">6</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">OWNED</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">162,100</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">EACH</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">7</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">REPORTING</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">WITH:</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">8</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">162,100</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">9</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        162,100</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">10</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt"><font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">11</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        0.52%</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">12</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">TYPE OF REPORTING PERSON*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        OO</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>
            </table>
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            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="171">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="5">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="286">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="20%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="171">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">CUSIP No.&nbsp;759916109</font></b></p>
                    </td>

                    <td valign="top" width="5">&nbsp;</td>

                    <td valign="top" width="286">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="20%">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="center"><b><font style="FONT-SIZE: 10pt">Page 6 of 10 Pages</font></b></p>
                    </td>
                </tr>
            </table>
            <br>

            <p></p>

            <p></p>

            <table style="BORDER-TOP: #000000 2px solid" cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">1</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">NAME OF REPORTING PERSON:<br>
                        </font><b><font style="FONT-SIZE: 10pt">BVF Partners L.P.</font></b><br>
                        <font style="FONT-SIZE: 10pt">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">2</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(a)&nbsp;&nbsp;<font face="Wingdings" size="+0">x</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(b)&nbsp;&nbsp;<font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">3</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SEC USE ONLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="8%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">4</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="8%">&nbsp;</td>
                </tr>

                <tr style="BORDER-TOP: #000000 2px solid">
                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="6%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="1%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="82%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        Delaware</font></b></p>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="3%"><br>
                    </td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" width="8%"><br>
                    </td>
                </tr>
            </table>
            <br>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">5</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">NUMBER OF</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">SHARES</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BENEFICIALLY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">6</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED VOTING POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">OWNED</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">2,731,350</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BY</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">EACH</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">7</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">REPORTING</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">WITH:</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">8</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED DISPOSITIVE POWER</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="19%" colspan="3">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="70%" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">2,731,350</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">9</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        2,731,350</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">10</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt"><font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5"><br>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">11</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        8.76%</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">12</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">TYPE OF REPORTING PERSON*</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>
                        PN</font></b></p>
                    </td>

                    <td valign="top" width="3%"><br>
                    </td>

                    <td valign="top" width="6%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="9">&nbsp;</td>
                </tr>
            </table>
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            <div title="EE+ Page Break" style="FONT-SIZE: 1pt; PAGE-BREAK-AFTER: always; WIDTH: 100%; HEIGHT: 1px">
            </div>

            <p></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="3">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="4">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="5">
                        <p align="right">&nbsp;</p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: #000000 2px solid; BORDER-BOTTOM: #000000 2px solid" valign="top" colspan="5">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">CUSIP No. 759916109</font></b></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" colspan="3">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="4">&nbsp;</td>

                    <td style="BORDER-BOTTOM: #000000 2px solid" valign="top" colspan="5">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">Page 7 of 10 Pages</font></b></p>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-BOTTOM: black 2px solid" valign="top" colspan="16">&nbsp;&nbsp;&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">1</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">NAME OF REPORTING PERSON:<br>
                        </font><b><font style="FONT-SIZE: 10pt">BVF Inc.</font></b><br>
                        <font style="FONT-SIZE: 10pt">S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="8%" colspan="2">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">2</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="8%" colspan="2">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(a)&nbsp;&nbsp;<font face="Wingdings" size="+0">x</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="10">&nbsp;</td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="8%" colspan="2">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right"><font style="FONT-SIZE: 10pt">(b)&nbsp; <font face="Wingdings" size="+0">o</font></font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="10">&nbsp;</td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="8%" colspan="2">&nbsp;</td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">3</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SEC USE ONLY</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="8%" colspan="2">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%" colspan="10"><br>
                    </td>

                    <td valign="top" width="3%" colspan="2"><br>
                    </td>

                    <td valign="top" width="8%" colspan="2"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">4</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="82%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CITIZENSHIP OR PLACE OF ORGANIZATION</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="8%" colspan="2">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="82%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        Delaware</font></b></p>
                    </td>

                    <td valign="top" width="3%" colspan="2"><br>
                    </td>

                    <td valign="top" width="8%" colspan="2"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">&nbsp;</td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">5</font></b></p>
                    </td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE VOTING POWER</font></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">NUMBER OF</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">SHARES</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="10">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BENEFICIALLY</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">6</font></b></p>
                    </td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED VOTING POWER</font></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">OWNED</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">2,731,350</font></b></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">BY</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="10">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">EACH</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">7</font></b></p>
                    </td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SOLE DISPOSITIVE POWER</font></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">REPORTING</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">0</font></b></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">PERSON</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="10">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">WITH:</font></p>
                    </td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">8</font></b></p>
                    </td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">SHARED DISPOSITIVE POWER</font></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td valign="top" colspan="4">&nbsp;</td>

                    <td valign="top" colspan="2">&nbsp;</td>

                    <td valign="top" width="6%">&nbsp;</td>

                    <td valign="top" width="6%">
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="258">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">2,731,350</font></b></p>
                    </td>

                    <td valign="top" width="4">
                    </td>

                    <td valign="top" width="25">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>

                    <td valign="top" width="70%">
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">9</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="5%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        2,731,350</font></b></p>
                    </td>

                    <td valign="top" width="3%" colspan="2"><br>
                    </td>

                    <td valign="top" width="5%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">10</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="right">&nbsp;</p>
                        <font face="Wingdings" size="+0">o</font>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="10"><br>
                    </td>

                    <td valign="top" width="3%" colspan="2"><br>
                    </td>

                    <td valign="top" width="5%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">11</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="5%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        8.76%</font></b></p>
                    </td>

                    <td valign="top" width="3%" colspan="2"><br>
                    </td>

                    <td valign="top" width="5%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">12</font></b></p>
                    </td>

                    <td valign="top" width="1%">&nbsp;</td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">TYPE OF REPORTING PERSON*</font></p>
                    </td>

                    <td valign="top" width="3%" colspan="2">&nbsp;</td>

                    <td valign="top" width="5%">&nbsp;</td>
                </tr>

                <tr>
                    <td valign="top" width="6%" colspan="2"><br>
                    </td>

                    <td valign="top" width="1%"><br>
                    </td>

                    <td valign="top" width="83%" colspan="10">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">&nbsp;&nbsp;&nbsp;<br>
                        IA, CO</font></b></p>
                    </td>

                    <td valign="top" width="3%" colspan="2"><br>
                    </td>

                    <td valign="top" width="5%"><br>
                    </td>
                </tr>

                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" colspan="16">&nbsp;</td>
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                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="8">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="53%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="20%">&nbsp;</td>
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                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">CUSIP No.&nbsp;759916109</font></b></p>
                    </td>

                    <td valign="top" width="8">&nbsp;</td>

                    <td valign="top" width="53%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid; BORDER-BOTTOM: black 1.5pt solid" valign="top" width="20%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">Page 8 of 10 Pages</font></b></p>
                    </td>
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            </table>
            <br>
            <br>

            <p style="TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 1(a).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NAME OF ISSUER:</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">Repligen Corporation (&ldquo;RGEN&rdquo;)<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 1(b).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ADDRESS OF ISSUER&rsquo;S PRINCIPAL EXECUTIVE OFFICES:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">41 Seyon Street Building 1, Suite 100</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">Waltham, Massachusetts 02453<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 2(a).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NAME OF PERSON FILING:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">This Amendment No. 4 to Schedule 13G is being filed on behalf of the following persons (the &ldquo;Reporting Persons&rdquo;):&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="14%">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(i)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="78%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Biotechnology Value Fund, L.P. (&ldquo;BVF&rdquo;)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="14%">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(ii)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="78%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Biotechnology Value Fund II, L.P. (&ldquo;BVF2&rdquo;)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="14%">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(iii)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="78%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">BVF Investments, L.L.C. (&ldquo;Investments&rdquo;)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="14%">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(iv)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="78%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Investment 10, L.L.C. (&ldquo;ILL10&rdquo;)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="14%">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(v)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="78%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">BVF Partners L.P. (&ldquo;Partners&rdquo;)</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="14%">&nbsp;</td>

                    <td valign="top" width="5%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><font style="FONT-SIZE: 10pt">(vi)</font></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="78%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">BVF&nbsp;Inc. (&ldquo;BVF&nbsp;Inc.&rdquo;)</font></p>
                    </td>
                </tr>
            </table>
            <br>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 2(b).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ADDRESS OF PRINCIPAL BUSINESS OFFICE:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">The principal business office of the Reporting Persons comprising the group filing this Schedule&nbsp;13G is located at 900 North Michigan Avenue, Suite 1100, Chicago, Illinois, 60611.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 2(c).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CITIZENSHIP:</font></b></p>

            <p></p>

            <table cellspacing="0" cellpadding="0" width="100%" border="0">
                <tr>
                    <td valign="top" width="11%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="18%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">BVF:</font></p>
                    </td>

                    <td valign="top" width="68%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">a Delaware limited partnership</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="11%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="18%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">BVF2:</font></p>
                    </td>

                    <td valign="top" width="68%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">a Delaware limited partnership</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="11%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="18%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Investments:</font></p>
                    </td>

                    <td valign="top" width="68%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">a Delaware limited liability company</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="11%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="18%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">ILL10:</font></p>
                    </td>

                    <td valign="top" width="68%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">an Illinois limited liability company</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="11%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="18%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Partners:</font></p>
                    </td>

                    <td valign="top" width="68%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">a Delaware limited partnership</font></p>
                    </td>
                </tr>

                <tr>
                    <td valign="top" width="11%">&nbsp;</td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td valign="top" width="18%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">BVF&nbsp;Inc.:</font></p>
                    </td>

                    <td valign="top" width="68%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">a Delaware corporation</font></p>
                    </td>
                </tr>
            </table>
            &nbsp;&nbsp;&nbsp;<br>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 2(d).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;TITLE OF CLASS OF SECURITIES:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">This Amendment No. 4 to Schedule 13G is being filed with respect to the common stock, par value $0.01 per share (&ldquo;Common Stock&rdquo;), of RGEN. The Reporting Persons&rsquo; percentage ownership of Common Stock is based on 31,184,534 shares of Common Stock being outstanding.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px"><font style="FONT-SIZE: 10pt">As of December 31, 2008, BVF beneficially owned 667,150 shares of Common Stock, BVF2 beneficially owned 425,400 shares of Common Stock, Investments beneficially owned 1,476,700 shares of Common Stock and ILL10 beneficially owned 162,100 shares of Common Stock. Beneficial ownership by Partners and BVF Inc. includes 2,731,350 shares of Common Stock.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>
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                </tr>

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                    <td valign="top" width="138">
                        <p style="BORDER-TOP: 1.5pt solid; MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px; BORDER-BOTTOM: 1.5pt solid" align="left"><b><font style="FONT-SIZE: 10pt">CUSIP No. 759916109</font></b></p>
                    </td>

                    <td valign="top" width="6">&nbsp;</td>

                    <td valign="top" width="53%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid; BORDER-BOTTOM: black 1.5pt solid" valign="top" width="20%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">Page 9 of 10 Pages</font></b></p>
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            &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 2(e).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CUSIP Number: 759916109<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), or 13d-2(b) or (c)&nbsp;CHECK WHETHER THE PERSON FILING IS: &nbsp;&nbsp;&nbsp;One of the following<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">Not applicable as this Amendment No. 4 to Schedule&nbsp;13G is filed pursuant to Rule&nbsp;13d-1(c).<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">The information in items 1 and 5 through 11 on the cover pages (pp. 2&nbsp;-&nbsp;7) on this Amendment No. 4 to Schedule&nbsp;13G is hereby incorporated by reference.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following.&nbsp; [ ].<br>
            </font></p>

            <p style="TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:<br>
            <br>
            </font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">Pursuant to the operating agreement of Investments, Partners is authorized, among other things, to invest the funds of Samana Capital, L.P., the majority member of Investments, in shares of the Common Stock beneficially owned by Investments and to vote and exercise dispositive power over those shares of the Common Stock. Partners and BVF&nbsp;Inc. share
            voting and dispositive power over shares of the Common Stock beneficially owned by BVF, BVF2, Investments and those owned by ILL10, on whose behalf Partners acts as an investment manager and, accordingly, Partners and BVF&nbsp;Inc. have beneficial ownership of all of the shares of the Common Stock owned by such parties.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in" align="left"><b style="TEXT-INDENT: 0px"><font style="FONT-SIZE: 10pt">ITEM 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:&nbsp;<br>
            &nbsp;&nbsp;&nbsp;<br>
            </font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">Mr. Lampert is the owner, sole director and an officer of BVF Inc. BVF Inc. is the general partner of Partners, which is the general partner of BVF and BVF 2. Partners is the manager of Investments and is investment adviser to ILL10.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">The members of the group making this filing of Amendment No. 4 to Schedule 13G are: Biotechnology Value Fund, L.P., Biotechnology Value Fund II, L.P., BVF Investments, L.L.C., Investment 10, L.L.C., BVF Partners L.P. and BVF Inc.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NOTICE OF DISSOLUTION OF GROUP:<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">Not applicable.</font></p>
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                <br>
                <br>
            </div>

            <p></p>

            <p></p>

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                <tr>
                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="143">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="1">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="53%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid" valign="top" width="3%">&nbsp;</td>

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                </tr>

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                    <td style="BORDER-TOP: black 1.5pt solid; BORDER-BOTTOM: black 1.5pt solid" valign="top" width="143">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">CUSIP No. 759916109</font></b></p>
                    </td>

                    <td valign="top" width="1">&nbsp;</td>

                    <td valign="top" width="53%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">13G</font></b></p>
                    </td>

                    <td valign="top" width="3%">&nbsp;</td>

                    <td style="BORDER-TOP: black 1.5pt solid; BORDER-BOTTOM: black 1.5pt solid" valign="top" width="20%">
                        <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">Page 10 of 10 Pages</font></b></p>
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            &nbsp;&nbsp;&nbsp;&nbsp;

            <p></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">ITEM 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CERTIFICATION<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that
            purpose or effect.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 72px" align="left"><font style="FONT-SIZE: 10pt">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.<br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Dated: January 30, 2009</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt"><br>
            &nbsp;&nbsp;&nbsp;&nbsp;</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BIOTECHNOLOGY VALUE FUND, L.P.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert_________</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BIOTECHNOLOGY VALUE FUND II, L.P.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its general partner</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert_________</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BVF INVESTMENTS, L.L.C.*</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its manager</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert_________</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">INVESTMENT 10, L.L.C.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its investment manager</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert_________</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 27pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BVF PARTNERS L.P.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert_________</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 17pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BVF INC.*</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert_________</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 36pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">*The Reporting Person disclaims beneficial ownership except to the extent of its pecuniary interest therein.</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left">&nbsp;</p>
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            <p style="MARGIN-TOP: 0pt; FONT-SIZE: 12pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">Exhibit A</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="center"><b><font style="FONT-SIZE: 10pt">JOINT FILING AGREEMENT</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">The undersigned agree that this Amendment No. 4 to Schedule 13G, dated December 31, 2008, relating to the Common Stock of RGEN shall be filed on behalf of the undersigned.</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">Dated:</font> <font style="FONT-SIZE: 10pt">January 30, 2009</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BIOTECHNOLOGY VALUE FUND, L.P.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BIOTECHNOLOGY VALUE FUND II, L.P.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its general partner</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 12pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BVF INVESTMENTS, L.L.C.*</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its manager</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">INVESTMENT 10, L.L.C.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Partners, L.P., its investment manager</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 27pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BVF PARTNERS L.P.*</font></b></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><font style="FONT-SIZE: 10pt">By: BVF Inc., its general partner</font></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 17pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>

            <p style="MARGIN-TOP: 5pt; MARGIN-BOTTOM: 5pt; MARGIN-LEFT: 0in; TEXT-INDENT: 0px" align="left"><b><font style="FONT-SIZE: 10pt">BVF INC.*</font></b></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 0pt; MARGIN-LEFT: 0in; TEXT-INDENT: 36px" align="left"><font style="FONT-SIZE: 10pt">By:</font> <u><font style="FONT-SIZE: 10pt">/s/ Mark N. Lampert&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></u></p>

            <p style="MARGIN-TOP: 0pt; MARGIN-BOTTOM: 36pt; MARGIN-LEFT: 0in; TEXT-INDENT: 54px" align="left"><font style="FONT-SIZE: 10pt">Mark N. Lampert, President</font></p>
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