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Revenue Recognition - Additional Information (Detail) (USD $)
3 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Pfizer Incorporation
Nonsoftware License Arrangement
Jun. 30, 2013
Pfizer Incorporation
Nonsoftware License Arrangement
Dec. 31, 2012
Pfizer Incorporation
Nonsoftware License Arrangement
Jan. 31, 2013
Pfizer Incorporation
Nonsoftware License Arrangement
Up-front Payment Arrangement
Jun. 30, 2013
Orencia Royalties from Bristol
Jun. 30, 2012
Orencia Royalties from Bristol
Jun. 30, 2013
Orencia Royalties from Bristol
Jun. 30, 2012
Orencia Royalties from Bristol
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]                        
Royalty revenue $ 4,495,357 $ 3,864,581 $ 9,017,081 $ 7,346,441         $ 4,285,000 $ 3,580,000 $ 8,131,000 $ 6,660,000
Percentage of royalty revenue, remittance to the University of Michigan     15.00%                  
Cost of royalty and other revenue 642,736 536,933 1,219,593 999,021         643,000 537,000 1,220,000 999,000
Payment received under license agreement               5,000,000        
Total future milestone receivable         65,000,000 65,000,000            
License agreement, revenue recognized         68,000 124,000 4,876,000          
Revenue from sponsored research and development projects $ 142,000 $ 285,000 $ 762,000 $ 686,000