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Revenue Recognition - Additional Information (Detail) (USD $) | 3 Months Ended | 9 Months Ended | 1 Months Ended | 3 Months Ended | 9 Months Ended |  | 0 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 3 Months Ended | 9 Months Ended | 0 Months Ended | 9 Months Ended
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Sep. 30, 2014 | Mar. 31, 2014 | Sep. 30, 2013 | Sep. 30, 2014 | Sep. 30, 2013 | Sep. 30, 2014 Technology Transfer | Mar. 31, 2014 Technology Transfer | Sep. 30, 2014 Clinical Development | Sep. 30, 2014 Initial Commercial Sales | Sep. 04, 2013 Pfizer Incorporation Nonsoftware License Arrangement | Jan. 22, 2013 Pfizer Incorporation Nonsoftware License Arrangement | Sep. 30, 2014 Pfizer Incorporation Nonsoftware License Arrangement | Sep. 30, 2013 Pfizer Incorporation Nonsoftware License Arrangement | Sep. 30, 2014 Pfizer Incorporation Nonsoftware License Arrangement | Sep. 30, 2013 Pfizer Incorporation Nonsoftware License Arrangement | Dec. 31, 2013 Pfizer Incorporation Nonsoftware License Arrangement | Dec. 31, 2012 Pfizer Incorporation Nonsoftware License Arrangement | Sep. 30, 2014 Orencia Royalties from Bristol | Sep. 30, 2013 Orencia Royalties from Bristol | Sep. 30, 2014 Orencia Royalties from Bristol | Sep. 30, 2013 Orencia Royalties from Bristol | Jan. 30, 2014 BioMarin Pharmaceutical, Inc. Asset Purchase Agreement | Sep. 30, 2014 BioMarin Pharmaceutical, Inc. Asset Purchase Agreement | Sep. 30, 2014 BioMarin Pharmaceutical, Inc. Asset Purchase Agreement Clinical Development | Sep. 30, 2014 BioMarin Pharmaceutical, Inc. Asset Purchase Agreement Initial Commercial Sales
Revenue Recognition, Multiple-deliverable Arrangements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  |  |  |  |  |  |  |  | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  | $ 2,000,000 |  |  |
Potential milestone payments to be received |  |  |  |  |  |  |  | 60,000,000 | 100,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 160,000,000 |  |
Percentage relate to clinical development from Milestone payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 37.00% | 63.00%
Provision for refund |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |
License agreement, revenue recognized |  |  |  | 2,115,000 |  |  | 0 |  |  |  |  | 0 | 1,093,000 | 0 | 1,217,000 |  | 4,876,000 |  |  |  |  |  | 2,100,000 |  |
Non-refundable up-front payment |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment to be received upon signing of agreement |  |  |  | 125,675 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized under revenue recognition, up front payment |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated selling price |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consideration allocated to transaction |  |  |  |  |  | 11,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty and other revenue | 125,675 |  | 6,637,838 | 2,116,841 | 15,654,919 | 125,675 |  |  |  |  |  |  |  |  |  |  |  | 0 | 4,825,000 | 0 | 12,956,000 |  |  |  |
Milestone payment |  |  |  |  |  |  |  | 60,000,000 |  | 1,000,000 |  |  |  |  |  | 1,000,000 |  |  |  |  |  |  |  |  |
Potential milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  | 64,000,000 |  | 64,000,000 |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty revenue, remittance to the University of Michigan |  |  |  | 15.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of royalty revenue |  |  | 723,777 |  | 1,943,370 |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 724,000 | 0 | 1,943,000 |  |  |  |
Revenue from sponsored research and development projects | $ 0 |  | $ 719,000 | $ 0 | $ 1,481,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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