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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2015
Stock-Based Compensation Expense | The following table presents stock-based compensation expense in the Company’s consolidated statements of operations (in thousands):
|  | Years ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Cost of product revenue |  | $ | 213 |  |  | $ | 128 |  |  | $ | 74 |
Research and development |  |  | 336 |  |  |  | 185 |  |  |  | 97 |
Selling, general and administrative |  |  | 3,049 |  |  |  | 1,453 |  |  |  | 889 |
Total |  | $ | 3,598 |  |  | $ | 1,766 |  |  | $ | 1,060 |
Estimated Weighted Average Assumptions | The fair value of share-based awards granted during the years ended December 31, 2015, 2014 and 2013 were calculated using the following estimated assumptions:
|  | 2015 |  | 2014 |  | 2013
Expected term (years) |  | 6.6 -7.2 |  | 6.5 |  | 6.5
Volatility |  | 50.09 - 51.89% |  | 51.00 - 51.71% |  | 51.39% - 53.63%
Risk-free interest rate |  | 1.67 – 2.03% |  | 1.88 - 2.11% |  | 1.09% - 2.08%
Expected dividend yield |  | — |  | — |  | —
Summary of Option Activity | Information regarding option activity for the year ended December 31, 2015 under the Plans is summarized below:
|  | Options Outstanding |  |  | Weighted- Average Exercise Price Per Share |  |  | Weighted- Average Remaining Contractual Term (in years) |  |  | (in thousands) Aggregate Intrinsic Value |
Options outstanding at December 31, 2014 |  |  | 1,225,117 |  |  | $ | 8.31 |  |  |  |  |  |  |  |  |
Granted |  |  | 310,857 |  |  |  | 15.23 |  |  |  |  |  |  |  |  |
Exercised |  |  | (177,693 | ) |  |  | 5.22 |  |  |  |  |  |  |  |  |
Forfeited/cancelled |  |  | (117,346 | ) |  |  | 8.81 |  |  |  |  |  |  |  |  |
Options outstanding at December 31, 2015 |  |  | 1,240,935 |  |  | $ | 10.44 |  |  |  | 6.42 |  |  | $ | 22,653 |
Options exercisable at December 31, 2015 |  |  | 559,922 |  |  | $ | 6.77 |  |  |  | 3.89 |  |  | $ | 12,048 |
Vested and expected to vest at December 31, 2015 (1) |  |  | 1,183,574 |  |  | $ | 10.42 |  |  |  | 6.36 |  |  | $ | 21,652 |
(1) | This represents the number of vested options as of December 31, 2015 plus the number of unvested options expected to vest as of December 31, 2015 based on the unvested outstanding options at December 31, 2015 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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