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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2017
Investments in Debt Securities | Investments in debt securities consisted of the following at December 31, 2016 (in thousands):
|  | Amortized Cost |  |  | Gross Unrealized Gain |  |  | Gross Unrealized Loss |  |  | Fair Value |
Marketable securities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
U.S. Government and agency securities |  | $ | 807 |  |  | $ | — |  |  | $ | — |  |  | $ | 807 |
Corporate and other debt securities |  |  | 18,745 |  |  |  | 2 |  |  |  | (7 | ) |  |  | 18,740 |
Total |  | $ | 19,552 |  |  | $ | 2 |  |  | $ | (7 | ) |  | $ | 19,547 |
RollForward of Fair Value of Contingent Consideration | The following table provides a rollforward of the fair value of contingent consideration (in thousands):
Balance at December 31, 2016 |  | $ | 6,119 |
Payments |  |  | (6,119 | )
Balance at December 31, 2017 |  | $ | — |
Schedule of Inventories | Inventories consist of the following (in thousands):
|  | December 31, 2017 |  |  | December 31, 2016 |
Raw Materials |  | $ | 22,351 |  |  | $ | 14,954 |
Work-in-process |  |  | 4,083 |  |  |  | 2,789 |
Finished products |  |  | 12,570 |  |  |  | 6,953 |
Total |  | $ | 39,004 |  |  | $ | 24,696 |
Reconciliation of Basic and Diluted Shares Amounts | A reconciliation of basic and diluted share amounts is as follows:
|  | Years ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Numerator: |  |  |  |  |  |  |  |  |  |  |  |
Net income |  | $ | 28,353,000 |  |  | $ | 11,681,000 |  |  | $ | 9,345,000 |
Denominator: |  |  |  |  |  |  |  |  |  |  |  |
Basic weighted average common shares outstanding |  |  | 38,233,527 |  |  |  | 33,572,883 |  |  |  | 32,881,940 |
Effect of dilutive securities: |  |  |  |  |  |  |  |  |  |  |  |
Stock options and restricted stock awards |  |  | 441,924 |  |  |  | 526,015 |  |  |  | 695,151 |
Convertible senior notes |  |  | 474,923 |  |  |  | — |  |  |  | — |
Diluted weighted average common shares outstanding |  |  | 39,150,374 |  |  |  | 34,098,898 |  |  |  | 33,577,091 |
Basic net income per common share |  | $ | 0.74 |  |  | $ | 0.35 |  |  | $ | 0.28 |
Diluted net income per common share |  | $ | 0.72 |  |  | $ | 0.34 |  |  | $ | 0.28 |
Summary of Product Revenues by Product Line | The following table represents product revenues by product line (in thousands):
|  | December 31, 2017 |  |  | December 31, 2016 |  |  | December 31, 2015 |
Protein products |  | $ | 53,969 |  |  | $ | 54,716 |  |  | $ | 52,938 |
Filtration products |  |  | 49,050 | (3) |  |  | 19,774 | (1) |  |  | 15,676 |
Chromatography products |  |  | 36,309 | (3) |  |  | 29,520 | (2) |  |  | 14,613 |
Other |  |  | 1,761 | (3) |  |  | 431 |  |  |  | 310 |
Total product revenues |  | $ | 141,089 |  |  | $ | 104,441 |  |  | $ | 83,537 |
(1) | 2016 revenue for filtration products includes revenue related to TangenX from December 14, 2016 through December 31, 2016.
(2) | 2016 revenue for chromatography products includes revenue related to Atoll from April 1, 2016 through December 31, 2016.
(3) | 2017 revenue for filtration, chromatography and other products includes revenue related to Spectrum from August 1, 2017 through December 31, 2017.
Total Assets by Geographic Area | The following table represents the Company’s total assets by geographic area (in thousands):
|  | December 31, 2017 |  |  | December 31, 2016 |
United States |  | $ | 654,673 |  |  | $ | 209,728 |
Europe |  |  | 85,169 |  |  |  | 79,145 |
Asia |  |  | 3,677 |  |  |  | 40 |
Total |  | $ | 743,519 |  |  | $ | 288,913 |
Long Lived Assets by Geographic Area | The following table represents the Company’s long-lived assets by geographic area (in thousands):
|  | December 31, 2017 |  |  | December 31, 2016 |
United States |  | $ | 465,453 |  |  | $ | 77,039 |
Europe |  |  | 34,430 |  |  |  | 27,721 |
Asia |  |  | 854 |  |  |  | — |
Total |  | $ | 500,737 |  |  | $ | 104,760 |
Percentage of Revenue from Significant Customers | Revenue from significant customers as a percentage of the Company’s total revenue is as follows:
|  | Years ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
GE Healthcare |  |  | 21 | % |  |  | 29 | % |  |  | 37 | %
MilliporeSigma |  |  | 18 | % |  |  | 28 | % |  |  | 29 | %
Intangible assets | Intangible assets consisted of the following at December 31, 2017 (in thousands):
|  | Gross Carrying Amount |  |  | Accumulated Amortization |  |  | Weighted Average Useful Life (in years) |
Technology – developed |  | $ | 51,801 |  |  | $ | (3,201 | ) |  |  | 19 |
Patents |  |  | 240 |  |  |  | (238 | ) |  |  | 8 |
Customer relationships |  |  | 102,120 |  |  |  | (9,636 | ) |  |  | 14 |
Trademarks – definite lived |  |  | 2,160 |  |  |  | (47 | ) |  |  | 20 |
Trademarks – indefinite lived |  |  | 700 |  |  |  | — |  |  |  | — |
Other intangibles |  |  | 1,063 |  |  |  | (209 | ) |  |  | 3 |
Total intangible assets |  | $ | 158,084 |  |  | $ | (13,331 | ) |  |  | 16 |
Intangible assets consisted of the following at December 31, 2016 (in thousands):
|  | Gross Carrying Amount |  |  | Accumulated Amortization |  |  | Weighted Average Useful Life (in years) |
Technology – developed |  | $ | 12,911 |  |  | $ | (1,468 | ) |  |  | 17 |
Patents |  |  | 240 |  |  |  | (208 | ) |  |  | 8 |
Customer relationships |  |  | 22,555 |  |  |  | (4,995 | ) |  |  | 11 |
Trademark/ tradename |  |  | 711 |  |  |  | — |  |  |  | — |
Other intangibles |  |  | 84 |  |  |  | (24 | ) |  |  | 2 |
Total intangible assets |  | $ | 36,501 |  |  | $ | (6,695 | ) |  |  | 13 |
Schedule of Amortization Expense for Amortized Intangible Assets | As of December 31, 2017, the Company expects to record the following amortization expense (in thousands):
Year Ending |  | Amortization Expense |
December 31, 2018 |  | $ | 10,633 |
December 31, 2019 |  |  | 10,578 |
December 31, 2020 |  |  | 9,894 |
December 31, 2021 |  |  | 9,376 |
December 31, 2022 |  |  | 9,374 |
Total Revenue |
Percentage by Geographic Area or Significant Customers | The following table represents the Company’s total revenue by geographic area (based on the location of the customer):
|  | Years ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
United States |  |  | 43 | % |  |  | 39 | % |  |  | 28 | %
Sweden |  |  | 20 | % |  |  | 29 | % |  |  | 37 | %
United Kingdom |  |  | 4 | % |  |  | 7 | % |  |  | 17 | %
Other |  |  | 33 | % |  |  | 25 | % |  |  | 18 | %
Total |  |  | 100 | % |  |  | 100 | % |  |  | 100 | %
Accounts Receivable |
Percentage by Geographic Area or Significant Customers | Significant accounts receivable balances as a percentage of the Company’s total trade accounts receivable and royalties and other receivable balances are as follows:
|  | December 31, 2017 |  |  | December 31, 2016 |
GE Healthcare |  |  | 11 | % |  |  | 26 | %
MilliporeSigma |  |  | 19 | % |  |  | 8 | %

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