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Summary of Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Jan. 31, 2014 USD ($) | Dec. 31, 2017 USD ($) Segment $ / shares shares | Dec. 31, 2016 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Jan. 01, 2018 USD ($) | Jan. 01, 2017 USD ($) | May 24, 2016 USD ($)
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Long-term marketable securities, minimum original maturity term |  |  | 1 year |  |  |  |
Investment fund |  | $ 0 |  |  |  |  |
Long-term marketable securities |  |  | $ 0 |  |  |  |
Gain (loss) on investments |  | 0 | 0 | $ 0 |  |  |
Fair value of other assets |  | 0 |  |  |  |  |
Fair value of other liabilities |  | 0 |  |  |  |  |
Accrued liability contingent consideration |  |  | 6,119,000 |  |  |  |
Reserves for excess and obsolete inventory |  | $ 455,000 | $ 435,000 |  |  |  |
Stock options, outstanding | shares |  | 734,940 | 882,748 |  |  |  |
Stock options, weighted average exercise price | $ / shares |  | $ 20.80 | $ 16.88 |  |  |  |
Common stock excluded from calculation of diluted earnings per share | shares |  | 317,923 | 381,686 | 196,209 |  |  |
Number of operating segment | Segment |  | 1 |  |  |  |  |
Number of reporting segment | Segment |  | 2 |  |  |  |  |
Goodwill impairment |  | $ 0 | $ 0 | $ 0 |  |  |
Amortization expense |  | 6,215,000 | 2,052,000 | $ 1,600,000 |  |  |
Restricted Cash |  |  | 450,000 |  |  |  |
ASU No. 2016-09 | U. S. Federal and State Jurisdiction |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Net operating loss carry forwards |  |  |  |  |  | $ 5,100,000 |
Increase in valuation allowance |  |  |  |  |  | 5,100,000 |
Impact of adopting ASU 2016-09 on retained earnings |  |  |  |  |  | $ 0 |
2.125% Convertible Senior Notes due 2021 |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Principal amount |  | $ 11,000 |  |  |  |  | $ 115,000,000
Notes, due date |  | Jun. 01, 2021 |  |  |  |  |
Notes, frequency of periodic payment |  | Semi-annually |  |  |  |  |
Notes, date of first required payment |  | Dec. 01, 2016 |  |  |  |  |
Total convertible senior notes |  | $ 99,250,000 | $ 95,272,000 |  |  |  |
Fair value of convertible senior notes |  | $ 149,500,000 |  |  |  |  |
Minimum |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Short-term marketable securities, minimum original maturity term |  |  | 90 days |  |  |  |
Restricted Stock Units (RSUs) |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Restricted stock units, outstanding | shares |  | 505,235 | 353,838 |  |  |  |
Restricted Stock Units (RSUs) | Awards Granted to Non-Executive Level Employees |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Estimated forfeiture rates |  | 8.00% |  |  |  |  |
Restricted Stock Units (RSUs) | Awards Granted to Executive Level Employees |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Estimated forfeiture rates |  | 3.00% |  |  |  |  |
Option To Purchase Common Stock |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Stock options, outstanding | shares |  | 734,940 | 1,236,586 | 1,240,935 |  |  |
Stock options, weighted average exercise price | $ / shares |  | $ 20.80 | $ 12.05 | $ 10.44 |  |  |
Employee Stock Option | Awards Granted to Non-Executive Level Employees |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Estimated forfeiture rates |  | 8.00% |  |  |  |  |
Employee Stock Option | Awards Granted to Executive Level Employees |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Estimated forfeiture rates |  | 3.00% |  |  |  |  |
Non-Employee Directors |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Estimated forfeiture rates |  | 0.00% |  |  |  |  |
BioMarin Pharmaceutical, Inc. | Asset Purchase Agreement |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Potential milestone payments to be received | $ 160,000,000 |  |  |  |  |  |
Provision for refund | $ 0 |  |  |  |  |  |
BioMarin Pharmaceutical, Inc. | Clinical Development | Asset Purchase Agreement |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Percentage relate to clinical development from Milestone payment | 37.00% |  |  |  |  |  |
BioMarin Pharmaceutical, Inc. | Initial Commercial Sales | Asset Purchase Agreement |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Percentage relate to clinical development from Milestone payment | 63.00% |  |  |  |  |  |
Subsequent Event | ASU No. 2016-18 |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Restricted Cash |  |  |  |  | $ 450,000 |  |

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