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Stock-Based Compensation (Tables) | 3 Months Ended
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Mar. 31, 2018
Stock-Based Compensation Expense | The following table presents stock-based compensation expense included in the Company’s consolidated statements of comprehensive income (in thousands):
|  | Three Months Ended March 31, |
|  | 2018 |  |  | 2017 |
Cost of product revenue |  | $ | 266 |  |  | $ | 141 |
Research and development |  |  | 170 |  |  |  | 132 |
Selling, general and administrative |  |  | 1,832 |  |  |  | 1,258 |
Total |  | $ | 2,268 |  |  | $ | 1,531 |
Summary of Option Activity | Information regarding option activity for the three-month period ended March 31, 2018 under the Plans is summarized below:
|  | Options Outstanding |  |  | Weighted- Average Exercise Price Per Share |  |  | Weighted- Average Remaining Contractual Term (in years) |  |  | (in thousands) Aggregate Intrinsic Value |
Options outstanding at December 31, 2017 |  |  | 734,940 |  |  | $ | 20.80 |  |  |  |  |  |  |  |  |
Granted |  |  | 398,532 |  |  |  | 33.85 |  |  |  |  |  |  |  |  |
Exercised |  |  | (14,531 | ) |  |  | 23.70 |  |  |  |  |  |  |  |  |
Forfeited/cancelled |  |  | (9,588 | ) |  |  | 29.71 |  |  |  |  |  |  |  |  |
Options outstanding at March 31, 2018 |  |  | 1,109,353 |  |  | $ | 25.34 |  |  |  | 7.51 |  |  | $ | 12,176 |
Options exercisable at March 31, 2018 |  |  | 499,504 |  |  | $ | 17.73 |  |  |  | 5.50 |  |  | $ | 9,300 |
Vested and expected to vest at March 31, 2018 (1) |  |  | 1,057,255 |  |  | $ | 24.96 |  |  |  | 7.40 |  |  | $ | 12,015 |
(1) | Represents the number of vested options as of March 31, 2018 plus the number of unvested options expected to vest as of March 31, 2018 based on the unvested outstanding options at March 31, 2018 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.
Restricted Stock Units and Performance Stock Units |
Summary of Restricted Stock Unit and Performance Stock Unit Activity | Information regarding restricted stock unit and performance stock unit activity for the three-month period ended March 31, 2018 under the Plans is summarized below:
|  | Units Outstanding |  |  | Weighted- Average Remaining Contractual Term (in years) |  |  | (in thousands) Aggregate Intrinsic Value |
Restricted and performance stock units outstanding at December 31, 2017 |  |  | 505,235 |  |  |  |  |  |  |  |  |
Granted |  |  | 319,701 |  |  |  |  |  |  |  |  |
Exercised |  |  | (90,691 | ) |  |  |  |  |  |  |  |
Forfeited/cancelled |  |  | (31,169 | ) |  |  |  |  |  |  |  |
Restricted stock units outstanding at March 31, 2018 |  |  | 703,076 |  |  |  | 4.06 |  |  | $ | 25,437 |
Vested and expected to vest at March 31, 2018 (1) |  |  | 639,530 |  |  |  | 3.75 |  |  | $ | 23,138 |
(1) | Represents the number of vested restricted stock units as of March 31, 2018 plus the number of unvested restricted stock units expected to vest as of March 31, 2018 based on the unvested outstanding restricted stock units at March 31, 2018 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.

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