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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Schedule of Cash, Cash Equivalents and Restricted Cash | Accordingly, the following is a summary of our cash, cash equivalents, and restricted cash total as presented in our consolidated statements of cash flows for the years ended December 31, 2018, 2017 and 2016:
|  | For the Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
|  | (Amounts in thousands) |
Cash and cash equivalents |  | $ | 193,822 |  |  | $ | 173,759 |  |  | $ | 122,233 |
Restricted cash |  |  | — |  |  |  | — |  |  |  | 450 |
Total cash, cash equivalents, and restricted cash |  | $ | 193,822 |  |  | $ | 173,759 |  |  | $ | 122,683 |
Property, Plant and Equipment | Property, Plant & Equipment is recorded at cost less allowances for depreciation. Depreciation is calculated using the straight-line method over the estimated useful life of the asset as follows:
Classification |  | Estimated Useful Life
Buildings |  | Thirty years
Leasehold improvements |  | Shorter of the term of the lease or estimated useful life
Equipment |  | Three to twelve years
Furniture and fixtures |  | Three to eight years
Reconciliation of Basic and Diluted Shares Amounts |
|  | For the Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
|  |  | (Amounts in thousands, except per share data) |
Net income |  | $ | 16,617 |  |  | $ | 28,353 |  |  | $ | 11,681 |
Weighted average shares used in computing net income per share - basic |  |  | 43,767 |  |  |  | 38,234 |  |  |  | 33,573 |
Effect of dilutive shares: |  |  |  |  |  |  |  |  |  |  |  |
Stock options and restricted stock awards |  |  | 581 |  |  |  | 441 |  |  |  | 526 |
Convertible senior notes |  |  | 1,123 |  |  |  | 475 |  |  |  | — |
Dilutive potential common shares |  |  | 1,704 |  |  |  | 916 |  |  |  | 526 |
Weighted average shares used in computing net income per share - diluted |  |  | 45,471 |  |  |  | 39,150 |  |  |  | 34,099 |
Earnings per share: |  |  |  |  |  |  |  |  |  |  |  |
Basic |  | $ | 0.38 |  |  | $ | 0.74 |  |  | $ | 0.35 |
Diluted |  | $ | 0.37 |  |  | $ | 0.72 |  |  | $ | 0.34 |
Summary of Product Revenues by Product Line | The following table represents product revenues by product line:
|  | For the Years Ended December 31, |
|  | 2018 |  |  | 2017 (1) |  |  | 2016 (2,3) |
|  | (Amounts in thousands) |
Chromatography products |  | $ | 45,326 |  |  | $ | 36,309 |  |  | $ | 29,520 |
Filtration products |  |  | 90,586 |  |  |  | 49,050 |  |  |  | 19,774 |
Protein products |  |  | 54,375 |  |  |  | 53,969 |  |  |  | 54,716 |
Other |  |  | 3,604 |  |  |  | 1,761 |  |  |  | 431 |
Total product revenue |  | $ | 193,891 |  |  | $ | 141,089 |  |  | $ | 104,441 |
(1) | 2017 revenue for filtration, chromatography and other products includes revenue related to Spectrum from August 1, 2017 through December 31, 2017.
(2) | 2016 revenue for filtration products includes revenue related to TangenX from December 14, 2016 through December 31, 2016.
(3) | 2016 revenue for chromatography products includes revenue related to Atoll from April 1, 2016 through December 31, 2016.
Total Assets by Geographic Area | The following table represents the Company’s total assets by geographic area:
|  | December 31, |
|  | 2018 |  |  | 2017 |
|  | (Amounts in thousands) |
Total assets by geographic locations: |  |  |  |  |  |  |  |
North America |  | $ | 665,833 |  |  | $ | 654,673 |
Europe |  |  | 104,750 |  |  |  | 85,169 |
APAC |  |  | 4,038 |  |  |  | 3,677 |
Total assets by geographic location |  | $ | 774,621 |  |  | $ | 743,519 |
Long Lived Assets by Geographic Area | The following table represents the Company’s long-lived assets by geographic area:
|  | December 31, |
|  | 2018 |  |  | 2017 |
|  | (Amounts in thousands) |
Long-lived assets by geographic locations: |  |  |  |  |  |  |  |
North America |  | $ | 464,253 |  |  | $ | 465,453 |
Europe |  |  | 29,426 |  |  |  | 34,430 |
APAC |  |  | 848 |  |  |  | 854 |
Total long-lived assets by geographic location |  | $ | 494,527 |  |  | $ | 500,737 |
Percentage of Revenue from Significant Customers | Revenue from significant customers as a percentage of the Company’s total revenue is as follows:
|  | For the Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
MilliporeSigma |  |  | 15 | % |  |  | 18 | % |  |  | 28 | %
GE Healthcare |  |  | 15 | % |  |  | 21 | % |  |  | 29 | %
Total Revenue |
Percentage by Geographic Area or Significant Customers | The following table represents the Company’s total revenue by geographic area (based on the location of the customer):
|  | For the Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Revenue by customers’ geographic locations: |  |  |  |  |  |  |  |  |  |  |  |
North America |  |  | 48 | % |  |  | 43 | % |  |  | 39 | %
Europe |  |  | 40 | % |  |  | 46 | % |  |  | 54 | %
APAC |  |  | 12 | % |  |  | 11 | % |  |  | 7 | %
Other |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Total revenue |  |  | 100 | % |  |  | 100 | % |  |  | 100 | %
Accounts Receivable |
Percentage by Geographic Area or Significant Customers | Significant accounts receivable balances as a percentage of the Company’s total trade accounts receivable and royalties and other receivable balances are as follows:
|  | December 31, |
|  | 2018 |  |  | 2017 |
GE Healthcare |  |  | 17 | % |  |  | 11 | %
MilliporeSigma |  |  | 11 | % |  |  | 19 | %

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