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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |  |
Net income | $ 16,617 | $ 28,353 | $ 11,681
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Depreciation and amortization | 15,778 | 10,507 | 5,334
Non-cash interest expense | 4,248 | 3,977 | 2,274
Stock-based compensation expense | 10,192 | 6,747 | 4,595
Deferred tax expense | 71 | (24,679) | (4,092)
Loss on revaluation of contingent consideration | 0 |  | 3,242
Other | (3) | 64 | (8)
Changes in operating assets and liabilities, excluding impact of acquisitions: |  |  |
Accounts receivable | (6,101) | (6,888) | (3,222)
Royalties and other receivables | 7 | 644 | (652)
Unbilled receivables | (2,602) |  |
Inventories | (4,042) | 605 | (6,163)
Prepaid expenses and other assets | (1,769) | (1,304) | 612
Accounts payable | 2,266 | 807 | (1,802)
Accrued expenses | (1,398) | (1,993) | (4,038)
Long-term liabilities | (494) | 611 | (240)
Total cash provided by operating activities | 32,770 | 17,451 | 7,521
Cash flows from investing activities: |  |  |
Purchases of marketable securities |  | (47) | (23,700)
Redemption of marketable securities |  | 19,600 | 23,400
Additions to capitalized software costs | (2,147) |  |
Developed technology intangible asset payment | (1,255) |  |
Proceeds from sale of fixed asset |  |  | 45
Purchases of property, plant and equipment | (10,635) | (5,454) | (4,325)
Total cash used in investing activities | (14,037) | (98,696) | (49,194)
Cash flows from financing activities: |  |  |
Proceeds from issuance of senior convertible notes, net of issuance costs |  |  | 111,070
Proceeds from issuance of common stock, net of issuance costs |  | 129,309 |
Exercise of stock options | 3,418 | 2,351 | 1,841
Repayment of senior convertible notes | (11) |  |
Payments of contingent consideration |  | (1,715) | (798)
Total cash provided by financing activities | 3,407 | 129,945 | 112,113
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (2,077) | 2,376 | (2,299)
Net increase in cash, cash equivalents and restricted cash | 20,063 | 51,076 | 68,141
Cash, cash equivalents and restricted cash, beginning of period | 173,759 | 122,683 | 54,542
Cash, cash equivalents and restricted cash, end of period | 193,822 | 173,759 | 122,683
Supplemental disclosure of cash flow information: |  |  |
Income taxes paid | 4,046 | 4,021 | 3,993
Interest paid | 2,444 | 2,444 | 1,222
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Non-cash effect of adoption of ASU 2016-16 | 5,609 |  |
Payment of contingent consideration in common stock | 0 | 1,063 | 875
Property, plant and equipment related to lease incentives | 2,270 |  |
Spectrum Lifesciences Inc. |  |  |
Cash flows from investing activities: |  |  |
Acquisition of assets, net of cash acquired |  | (112,795) |
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Common stock tendered for acquisition of assets | 0 | $ 247,575 |
Atoll GmbH |  |  |
Cash flows from investing activities: |  |  |
Acquisition of assets, net of cash acquired |  |  | (8,767)
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Common stock tendered for acquisition of assets | 0 |  | 14,135
TangenX Technology Corporation |  |  |
Cash flows from investing activities: |  |  |
Acquisition of assets, net of cash acquired |  |  | $ (35,847)

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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition from vendors of software programs or applications for internal use (that is, not to be sold, leased or otherwise marketed to others) that qualify for capitalization. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the development or modification of software programs or applications for internal use (that is, not to be sold, leased or otherwise marketed to others) that qualify for capitalization. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3151-108585 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109197908&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash outflow from the repayment of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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