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Stockholders' Equity (Tables) | 3 Months Ended
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Mar. 31, 2019
Stock-Based Compensation Expense | The following table presents stock-based compensation expense in the Company’s consolidated statements of comprehensive income:
|  | Three Months Ended March 31, |
|  | 2019 |  |  | 2018 |
|  | (Amounts in thousands) |
Cost of product revenue |  | $ | 324 |  |  | $ | 266 |
Research and development |  |  | 321 |  |  |  | 170 |
Selling, general and administrative |  |  | 2,606 |  |  |  | 1,832 |
Total stock-based compensation |  | $ | 3,251 |  |  | $ | 2,268 |
Estimated Weighted Average Assumptions | Information regarding option activity for the three months ended March 31, 2019 under the Plans is summarized below:
|  | Shares |  |  | Weighted average exercise price |  |  | Weighted- Average Remaining Contractual Term (in Years) |  |  | Aggregate Intrinsic Value (in Thousands) |
Options outstanding at December 31, 2018 |  |  | 998,226 |  |  | $ | 27.54 |  |  |  |  |  |  |  |  |
Granted |  |  | 31,498 |  |  | $ | 59.52 |  |  |  |  |  |  |  |  |
Exercised |  |  | (1,893 | ) |  | $ | 22.35 |  |  |  |  |  |  |  |  |
Forfeited/expired/cancelled |  |  | — |  |  | $ | — |  |  |  |  |  |  |  |  |
Options outstanding at March 31, 2019 |  |  | 1,027,831 |  |  | $ | 28.53 |  |  |  | 7.04 |  |  | $ | 31,469 |
Options exercisable at March 31, 2019 |  |  | 540,600 |  |  | $ | 21.66 |  |  |  | 5.54 |  |  | $ | 20,231 |
Vested and expected to vest at March 31, 2019 (1) |  |  | 985,138 |  |  |  |  |  |  |  | 6.96 |  |  | $ | 30,511 |
| (1) | Represents the number of vested options as of March 31, 2019 plus the number of unvested options expected to vest as of March 31, 2019 based on the unvested outstanding options at March 31, 2019 adjusted for estimated forfeiture rates of 8 % for awards granted to non-executive level employees and 3 % for awards granted to executive level employees.
Summary of Restricted Stock Unit Activity | Information regarding RSU activity for the three months ended March 31, 2019 under the Plans is summarized below:
|  | Shares |  |  | Weighted- Average Remaining Contractual Term (in Years) |  |  | Aggregate Intrinsic Value (in Thousands) |
Unvested at December 31, 2018 |  |  | 705,413 |  |  |  |  |  |  |  |  |
Awarded |  |  | 147,474 |  |  |  |  |  |  |  |  |
Vested |  |  | (154,837 | ) |  |  |  |  |  |  |  |
Forfeited/expired/cancelled |  |  | (17,501 | ) |  |  |  |  |  |  |  |
Unvested at March 31, 2019 |  |  | 680,549 |  |  |  | 3.88 |  |  | $ | 40,207 |
Vested and expected to vest at March 31, 2019 (1) |  |  | 622,851 |  |  |  | 3.54 |  |  | $ | 36,798 |
| (1) | Represents the number of vested RSUs units as of March 31, 2019 plus the number of unvested RSUs expected to vest as of March 31, 2019 based on the unvested outstanding RSUs at March 31, 2019 adjusted for estimated forfeiture rates of 8 % for awards granted to non-executive level employees and 3 % for awards granted to executive level employees.

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