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Stockholders' Equity (Tables) | 9 Months Ended
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Sep. 30, 2019
Stock-Based Compensation Expense | The following table presents stock-based compensation expense in the Company’s consolidated statements of comprehensive income (loss):
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
|  | (Amounts in thousands) |
Cost of product revenue |  | $ | 375 |  |  | $ | 277 |  |  | $ | 992 |  |  | $ | 777 |
Research and development |  |  | 351 |  |  |  | 253 |  |  |  | 992 |  |  |  | 650 |
Selling, general and administrative |  |  | 2,449 |  |  |  | 2,249 |  |  |  | 7,475 |  |  |  | 6,245 |
Total stock-based compensation |  | $ | 3,175 |  |  | $ | 2,779 |  |  | $ | 9,459 |  |  | $ | 7,672 |
Estimated Weighted Average Assumptions | Information regarding option activity for the nine months ended September 30, 2019 under the Plans is summarized below:
|  | Shares |  |  | Weighted average exercise price |  |  | Weighted- Average Remaining Contractual Term (in Years) |  |  | Aggregate Intrinsic Value (in Thousands) |
Options outstanding at December 31, 2018 |  |  | 998,226 |  |  | $ | 27.54 |  |  |  |  |  |  |  |  |
Granted |  |  | 44,996 |  |  | $ | 61.98 |  |  |  |  |  |  |  |  |
Exercised |  |  | (83,306 | ) |  | $ | 12.70 |  |  |  |  |  |  |  |  |
Forfeited/expired/cancelled |  |  | — |  |  | $ | — |  |  |  |  |  |  |  |  |
Options outstanding at September 30, 2019 |  |  | 959,916 |  |  | $ | 30.44 |  |  |  | 6.93 |  |  | $ | 44,396 |
Options exercisable at September 30, 2019 |  |  | 503,934 |  |  | $ | 24.18 |  |  |  | 5.64 |  |  | $ | 26,464 |
Vested and expected to vest at September 30, 2019 (1) |  |  | 923,962 |  |  |  |  |  |  |  | 6.87 |  |  | $ | 42,961 |
(1) | Represents the number of vested options as of September 30, 2019 plus the number of unvested options expected to vest as of September 30, 2019 based on the unvested outstanding options at September 30, 2019 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.
Summary of Restricted Stock Unit Activity | Information regarding RSU activity for the nine months ended September 30, 2019 under the Plans is summarized below:
|  | Shares |  |  | Weighted- Average Remaining Contractual Term (in Years) |  |  | Aggregate Intrinsic Value (in Thousands) |
Unvested at December 31, 2018 |  |  | 707,413 |  |  |  |  |  |  |  |  |
Awarded |  |  | 297,086 |  |  |  |  |  |  |  |  |
Vested |  |  | (228,103 | ) |  |  |  |  |  |  |  |
Forfeited/expired/cancelled |  |  | (36,183 | ) |  |  |  |  |  |  |  |
Unvested at September 30, 2019 |  |  | 740,213 |  |  |  | 3.85 |  |  | $ | 56,767 |

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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 + Details
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