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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |  |
Net income | $ 128,291 | $ 59,926 | $ 21,411
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Inventory step-up charges | 2,130 | 734 | 1,483
Depreciation and amortization | 38,447 | 27,067 | 20,868
Amortization of debt discount and issuance costs | 11,530 | 10,970 | 7,536
Stock-based compensation expense | 27,500 | 17,007 | 12,847
Contingent consideration expense | 5,865 |  |
Deferred income taxes, net | 6,517 | (3,992) | (624)
Loss on conversion of debt | 13 |  | 5,650
Other | 851 | 267 | 663
Changes in operating assets and liabilities, excluding impact of acquisitions: |  |  |
Accounts receivable | (46,523) | (20,892) | (7,830)
Unbilled receivables | (2) | 456 | 2,146
Inventories | (89,781) | (29,994) | (10,797)
Prepaid expenses and other assets | (10,192) | (4,870) | (595)
Operating lease right of use assets | (4,315) | 3,583 | (4,662)
Other assets | 432 | (281) | (66)
Accounts payable | 19,523 | 2,462 | 662
Accrued expenses | 23,196 | 1,037 | 13,096
Operating lease liability | 6,958 | (1,964) | 5,447
Long-term liabilities | (1,424) | 1,109 | (19)
Total cash provided by operating activities | 119,016 | 62,625 | 67,216
Cash flows from investing activities: |  |  |
Additions to capitalized software costs | (4,187) | (3,889) | (4,650)
Acquisition of assets, net of cash acquired | (149,893) | (175,041) | (182,154)
Purchases of property, plant and equipment | (67,089) | (22,455) | (18,504)
Total cash used in investing activities | (221,169) | (201,385) | (205,308)
Cash flows from financing activities: |  |  |
Proceeds from issuance of senior convertible notes, net of issuance costs |  |  | 278,466
Proceeds from issuance of common stock, net of issuance costs |  | 297,775 | 320,713
Exercise of stock options | 3,879 | 8,151 | 1,167
Repayment of senior convertible notes | (21) |  | (114,989)
Payment of tax withholding obligation on vesting of restricted stock | (2,897) | (10) | (490)
Total cash provided by financing activities | 961 | 305,916 | 484,867
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (12,286) | 12,729 | (3,190)
Net (decrease) increase in cash, cash equivalents and restricted cash | (113,478) | 179,885 | 343,585
Cash, cash equivalents and restricted cash, beginning of period | 717,292 | 537,407 | 193,822
Cash, cash equivalents and restricted cash, end of period | 603,814 | 717,292 | 537,407
Supplemental disclosure of cash flow information: |  |  |
Income taxes paid | 16,515 | 10,279 | 6,505
Interest paid | 1,066 | 1,066 | 1,484
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Assets acquired under operating leases | 85,312 | 3,349 | 8,663
Fair value of 2,316,229 shares of common stock issued for conversion of convertible notes |  |  | 198,757
C Technologies Inc |  |  |
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Fair value of common stock issued for acquisition |  |  | 53,938
ARTeSYN Biosolutions Holdings Ireland Limited |  |  |
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Fair value of common stock issued for acquisition |  | 69,422 |
Avitide Inc. |  |  |
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Fair value of common stock issued for acquisition | 82,968 | 0 | 0
Fair value of earnouts related to acquisition | $ 94,238 | $ 0 | $ 0

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